Pharmacoeconomic Analysis of Medicines Used for Bronchial Asthma in Children in Kazakhstan
Abstract
Background
This study aimed to calculate a pharmacoeconomic indicator, specifically the cost-effectiveness coefficient, for treating paediatric bronchial asthma with combined regimens of bronchodilators and inhaled corticosteroids.
Material and methods
This study involves 54 children aged 6 to 12 years, who were divided into 6 groups depending on the age and severity of bronchial asthma. Treatment effectiveness is calculated by subtracting the percentage difference between exacerbation frequency and the number of patients. The calculation of pharmacoeconomic data was conducted using the cost-effectiveness ratio (CER).
Results
For the treatment of mild bronchial asthma, the drug Berodual is used for inhalation through a nebuliser, moderate therapy is conducted using a combination of Flixotide and Salbutamol, and severe is stopped by a combination of Symbicort and Salbutamol. From the results obtained, notably, the CER for mild severity was 0.077 for children aged 6–8 years and 0.171 for the age group 9–12 years; for moderate severity, the CER values were 0.27 for the group 6–8 years and 0.35 for the category 9–12 years; severe asthma had the following indicators: 0.506 and 0.798 for groups aged 6–8 and 9–12, respectively.
Conclusion
This study’s results indicate that the most cost-effective treatment regimen is in the age groups of 6–8 years. However, the calculation of drug dosages directly depends on the patient’s age and the severity of the disease. Further actions in scientific works should be directed to conducting empirical, statistical studies in the field of pharmacoeconomics of bronchial asthma among children from the standpoint of the state.
© 2025 Elmira Serikbayeva, Nizom Suyunov, Baurzhan Makhatov, Ainash Atimtaikyzy, Aigul Ibragimova, Maksuda Abdullaeva, published by Institute of Mother and Child
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