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Umbilical cord arterial blood lactate dehydrogenase and pH as predictors of perinatal outcome in high-risk term pregnancies: A cohort study Cover

Umbilical cord arterial blood lactate dehydrogenase and pH as predictors of perinatal outcome in high-risk term pregnancies: A cohort study

By: Naina Kumar and  Ashu Yadav  
Open Access
|Jul 2022

Figures & Tables

Figure 1

Receiver operating characteristic (ROC) curves plotting the sensitivity and specificity of the umbilical cord arterial blood lactate dehydrogenase and pH values in the prediction of early neonatal mortality
Receiver operating characteristic (ROC) curves plotting the sensitivity and specificity of the umbilical cord arterial blood lactate dehydrogenase and pH values in the prediction of early neonatal mortality

Association between umbilical cord arterial blood pH, lactate dehydrogenase levels and overall neonatal outcome

ParameterNeonatal resuscitationNICU admissionEarly neonatal complicationsEarly neonatal death
YesNoYesNoYesNoYesNo
Cord blood pH<7.266(44.6% )82(55.4%)100(67.6 %)48(32.4% )79(53.4%)69(46.6%)15(10.1 %)133(89.9% )
≥7.29(5.9%)143(94.1 %)15(9.9%)137(90.1 %)11(7.2%)141(92.8 %)1(0.7%)151(99.3% )
Chi-square value59.82105.6176.0213.34
p-value0.0000.0000.0000.000
Cord blood<6126(3.2%)182(96.8 %)14(7.4%)174(92.6 %)9(4.8%)179(95.2 %)0(0%)188(100%)
LDH (U/L)≥61269(61.6% )43(38.4%)101(90.2 %)11(9.8%)81(72.3%)31(27.7%)16(14.3 %)96(85.7%)
Chi-square value127.74203.22152.4328.37
p-value0.0000.0000.0000.000

Participant Characteristics

ParameterNumber (n)Percentage
MATERNAL AGE (years)
19–2072.3%
21–3023277.3%
31–406122.3%
GRAVIDITY
G16220.7%
G29130.3%
G38628.7%
G43812.7%
≥ G5237.7%
PARITY
09230.7%
111337.7%
28127.0%
≥3144.7%
GESTATIONAL AGE (WEEKS)
>37– ≤3916755.7%
>39– ≤414040%
>41– ≤42134.3%
MODE OF DELIVERY
Normal vaginal delivery13344.3%
Emergency lower-segment caesarean section7525.0%
Elective lower-segment caesarean section4214.0%
Instrumental delivery4715.7%
Breech-assisted vaginal delivery31.0%
NEONATAL GENDER
Male16454.7%
Female13645.3%
NEONATAL BIRTH WEIGHT (KG)
≥1.5–≤2.53411.3%
>2.5–≤3.525384.3%
≥3.5134.3%
NEONATAL OUTCOME
Survived28494.7%
Early neonatal death165.3%

Association between mode of delivery, Apgar scores, cord blood pH and LDH levels

ParameterNormal vaginal deliveryEmergency LSCS*Elective LSCS*Instrumental deliveryAssisted breech deliveryTotalChi- square valueP value
1-min Apgar score
<714(15.2%)41(44.6%)4(4.3%)31(33.7%)2(2.2%)92(30.7%)83.880.000
>7119(57.2%)34(16.3%)38(18.3%)16(7.7%)1(0.5%)208(69.3%)
5-min Apgar score
<70(0%)5(62.5%)0(0%)2(25%)1(12.5%)8(2.7%)20.750.000
>7133(45.5%)70(24.0%)42(14.4%)45(15.4%)2(0.7%)292(97.3%)
Cord arterial blood pH
<7.237(25.0%)51(34.5%)16(10.8%)42(28.4%)2(1.4%)148(49.3%)67.690.000
≥7.296(63.2%)24(15.8%)26(17.1%)5(3.3%)1(0.7%)152(50.7%)
Cord arterial blood LDH
<612U/L112(59.6%)30(16.0%)35(18.6%)9(4.8%)2(1.1%)188(62.7%)88.590.000
≥612U/L21(18.8%)45(40.2%)7(6.3%)38(33.9%)1(0.9%)112(37.3%)
DOI: https://doi.org/10.34763/jmotherandchild.20222601.d-22-00004 | Journal eISSN: 2719-535X | Journal ISSN: 2719-6488
Language: English
Page range: 27 - 34
Submitted on: Jan 6, 2022
Accepted on: Mar 29, 2022
Published on: Jul 20, 2022
Published by: Institute of Mother and Child
In partnership with: Paradigm Publishing Services
Publication frequency: 1 issue per year

© 2022 Naina Kumar, Ashu Yadav, published by Institute of Mother and Child
This work is licensed under the Creative Commons Attribution 4.0 License.