Figure 1
Characteristics of patients and results of molecular investigation
| Patient No | Year of birth/sex | Localization of nevus | Melanoma arising in the nevus | Neurocutaneous melanosis (NCM) | Age during first operation | Number of operations | Treatment completed | CMN size | Satellite nevi | BRAF variants detected | NRAS variants detected |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 2011/m | B | 6/12 | 5 | + | >20 cm | + | none | p.Gln61Lys | ||
| 2 | 2012/m | H | + | 7/12 | 4 | > 0,5% PAS | 0 | none | none | ||
| 3 | 2012/m | H | 1/12 | 2 | + | 0,5 % PAS | 0 | none | p.Gln61Lys | ||
| 4 | 2009/f | BT | 4y | 6 | > 20 cm | ++ | none | none | |||
| 5 | 1989/f | N | 15y | 4 | + | > 20 cm | 0 | none | none | ||
| 6 | 2003/f | B | 1/12 | 5 | + | > 20 cm | + | none | none | ||
| 7 | 2007/f | BT | + | 1/12 | 14 | > 20 cm | 0 | none | none | ||
| 8 | 2011/m | B | 3/12 | 2 | + | > 20 cm | 0 | none | p.Gln61Lys | ||
| 9 | 2009/f | B | 4/12 | 8 | + | > 20 cm | + | none | none | ||
| 10 | 2007/f | H | 2y | 8 | > 0,5% PAS | + | none | p.Gln61Lys | |||
| 11 | 2011/f | B | 3/12 | 5 | + | > 20 cm | + | none | p.Gly12Asp | ||
| 12 | 2006/m | BT | + | 4/12 | 21 | > 20 cm | nd | none | none | ||
| 13 | 2009/m | B | + | 2y | 5 | > 20 cm | ++ | none | p.Gln61Lys | ||
| 14 | 2002/m | BT | 2y | 10 | + | not assessed | 0 | none | p.Gln61Arg | ||
| 15 | 2012/m | HN | 3/12 | 2 | > 0,5% PAS | 0 | none | none | |||
| 16 | 2010/f | B | + | 6/12 | 4 | + | > 20 cm | + | none | none | |
| 17 | 2006/f | BT | + | + | 6/12 | 13 | + | > 20 cm | nd | none | none |
| 18 | 2008/m | H | + | + | 1/12 | 3 | + | > 0,5% PAS | - | none | none |