Figure 1
Figure 2
The RegiSCAR-Group Diagnosis Score for drug rash with eosinophilia and systemic symptoms (DRESS) (12)
| Symptom | No | Yes | Unknown |
|---|---|---|---|
| Fever (≥ 38.5°C) | −1 | 0 | −1 |
| Enlarged lymph nodes (>=sites, >=1 cm) | 0 | 1 | 0 |
| Atypical lymphocytes | 0 | 1 | 0 |
| Eosinophilia, cells/μL | 0 | 0 | |
| 700–1,499 or 10%–19.9% | 1 | ||
| ≥ 1,500 or ≥20% | 2 | ||
| Skin rash | 0 | 0 | |
| Extent: >50% | 0 | 1 | 0 |
| At least two of these: oedema, infiltration, purpura, scaling | −1 | 1 | 0 |
| Biopsy suggesting DRESS | −1 | 0 | 0 |
| Internal organ involved | 0 | 0 | |
| One | 1 | ||
| Two or more | 2 | ||
| Resolution in >=15 days | −1 | 0 | −1 |
| At least three biological investigations performed and negative to exclude alternative diagnosis | 0 | 1 | 0 |
The results of laboratory tests during hospitalisation
| Results of the tests | ||||||
|---|---|---|---|---|---|---|
| Laboratory test | Laboratory norm | Day of hospitalisation | ||||
| 1 | 3 | 5 | 7 | 16 | ||
| CRP (mg/L) | <5.0 | 67.5 | 126.45 | 47.44 | 0.83 | |
| Procalcitonin (ng/mL) | <0.5 | 0.81 | 8.09 | 0.4 | ||
| Eosinophilia (%) | 2–4 | 21 | 30 | 36 | 0.56 | |
| Haemoglobin (g/dL) | 12.0–15.0 | 11.1 | 10.1 | 8.6 | 9.7 | |
| APTT (sec) | 27–40 | 47.2 | 53.5 | 32.5 | ||
| D-Dimers (ng/mL) | <500 | 1510 | 2578 | 900 | ||
| Albumin (g/dL) | 3.8–5.4 | 4.3 | 3.0 | 4.5 | ||
| Protein in the urine (mg/dL) | Not present | 10 | 50 | Not present | ||
| Creatinine (mg/dL) | 0.3–0.7 | 1.13 | 1.08 | 0.54 | ||
| ALT (U/L) | <44 | 12 | 12 | 12 | ||
| AST (U/L) | <48 | 18 | 12 | 14 | ||
| TSH (mIU/mL) | 0.3500– 4.9400 | 5.9817 | ||||
| fT4 (ng/dL) | 0.70–1.48 | 1.26 | ||||
| fT3 (pg/mL) | 1.71–3.71 | 2.18 | ||||