Table I
Distribution of clinical specimens by department.
| Department | Number of strains | Percentage |
|---|---|---|
| Intensive Care Unit (ICU) | 108 | 46.35% |
| Emergency Ward | 63 | 27.04% |
| Medical Insurance Center | 24 | 10.30% |
| Hematology Department | 9 | 3.86% |
| General Surgery Department | 9 | 3.86% |
| Other Departments | 20 | 8.58% |
| Total | 233 | 100% |
Table II
Distribution of clinical specimens by specimen type.
| Specimen type | Number of strains | Percentage |
|---|---|---|
| Respiratory tract (sputum, oropharyngeal swabs, bronchoscopy specimens) | 168 | 72.10% |
| Sterile body fluids (pleural fluid, ascitic fluid, drainage fluid) | 35 | 15.02% |
| Blood | 19 | 8.15% |
| Wound swabs | 5 | 2.15% |
| Urine | 6 | 2.58% |
| Total | 233 | 100% |
Table III
Antimicrobial susceptibility test results of 233 CRAB strains to SUL-DUR, ERV, and common antimicrobial agents.
| Antibiotics | Susceptible S (%) | Intermediate I (%) | Drug Resistance R (%) |
|---|---|---|---|
| Sulbactam-durlobactam | 92.3 | 1.7 | 6 |
| Eravacycline | 91.4 | - | - |
| Tigecycline | 75.0 | 20.0 | 5.0 |
| Ciprofloxacin | 5.8 | - | 94.2 |
| Ampicillin-sulbactam | 9.2 | - | 90.8 |
| Levofloxacin | 5.8 | 5.7 | 88.5 |
| Gentamicin | 4.6 | - | 95.4 |
| Amikacin | 12.7 | 3.4 | 83.9 |
| Piperacillin-tazobactam | 2.2 | 1.1 | 96.7 |
| Ceftazidime | 6.8 | 2.2 | 91.0 |
| Trimethoprim-sulfamethoxazole | 15.5 | 5.5 | 79 |
| Gentamicin | 4.6 | 9.2 | 86.2 |
| Imipenem | 0 | - | 100 |
| Meropenem | 0 | - | 100 |
Table IV
Cross-Analysis of Antimicrobial Susceptibility Test Results of CRAB to SUL-DUR and ERV[n(%)].
| SUL-DUR | ERV | Total | |
|---|---|---|---|
| Susceptible | Non-susceptible | ||
| Susceptible | 195(83.7) | 20 (8.6) | 215 (92.3) |
| Non-susceptible | 18 (7.7) | 0 (0) | 18 (7.7) |
| Total | 213 (91.4) | 20 (8.6) | 233 (100) |
Table V
Department and specimen source of Acinetobacter baumannii strains non-susceptible to SUL-DUR and ERV.
| Drug-resistant type | Number of strains | Department source (Strains) | Specimen type source (Strains) |
|---|---|---|---|
| Non-susceptible to SUL-DUR | 18 | ICU (11), Emergency Ward (4), Hematology Department (2), Medical Insurance Center (1) | Sputum or bronchoalveolar lavage fluid (15), Sterile site secretions (2), Blood (1) |
| Non-susceptible to ERV | 20 | ICU (11), Emergency Ward (4), Neurosurgery (1), Hematology Department (1), Urology (1), Thoracic Surgery (1), Medical Insurance Ward (1) | Sputum or bronchoalveolar lavage fluid (15), Sterile site drainage fluid (4), Clean-catch midstream urine (1) |
Fig. 1.
Distribution of resistance genes among the 14 strains of Acinetobacter baumannii.
Fig. 2.
Distribution of virulence genes among the 14 strains of Acinetobacter baumannii.
Fig. 3.
Heatmap of β-lactamase genotype correspondence among the 14 strains of Acinetobacter baumannii. Blue indicates the strain contains the corresponding genotype; white indicates the absence of the genotype.