Fig.1.
Schematic representation of the MR analysis.
Fig. 2.
IVW MR analysis of the causal association between oral microbiota and PLC.
Fig. 3.
Scatter plots depicting the MR analysis of the causal association between oral microbiota and PLC (risk factors).
Fig. 4.
Scatter plots depicting the MR analysis of the causal association between oral microbiota and PLC (protective factors).
Table I
Sensitivity analysis results of the MR study for PLC.
| Exposure | Heterogeneity analysis | Pleiotropy analysis | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Inverse variance weighted | MR Egger | MR Egger | MR PRESSO global test | |||||||
| Q | Q_df | Q_pval | Q | Q_df | Q_pval | Egger_ intercept | se | pval | pval | |
| g__TM7x | 14.15 | 15.00 | 0.51 | 14.11 | 14.00 | 0.44 | –0.20 | 1.01 | 0.84 | 0.50 |
| g__Streptococcus-1 | 13.55 | 14.00 | 0.48 | 13.54 | 13.00 | 0.41 | 0.05 | 0.58 | 0.93 | 0.56 |
| s__Fusobacterium_periodonticum-1 | 12.79 | 21.00 | 0.92 | 12.27 | 20.00 | 0.91 | –0.62 | 0.86 | 0.48 | 0.93 |
| s__Streptococcus_gordonii | 17.85 | 14.00 | 0.21 | 17.36 | 13.00 | 0.18 | –1.19 | 1.97 | 0.56 | 0.29 |
| s__Streptococcus-2 | 11.94 | 17.00 | 0.80 | 11.65 | 16.00 | 0.77 | –0.41 | 0.78 | 0.60 | 0.83 |
| g__Solobacterium | 14.12 | 15.00 | 0.52 | 14.05 | 14.00 | 0.45 | –0.22 | 0.83 | 0.80 | 0.56 |
| s__Capnocytophaga_sputigena | 8.40 | 16.00 | 0.94 | 8.40 | 15.00 | 0.91 | –0.04 | 1.27 | 0.97 | 0.96 |
| s__Fusobacterium_periodonticum-2 | 15.97 | 20.00 | 0.72 | 15.93 | 19.00 | 0.66 | 0.19 | 0.95 | 0.85 | 0.75 |
| s__Streptococcus-3 | 17.36 | 20.00 | 0.63 | 16.08 | 19.00 | 0.65 | 1.51 | 1.34 | 0.27 | 0.65 |
| s__Haemophilus | 8.52 | 13.00 | 0.81 | 7.46 | 12.00 | 0.83 | 0.60 | 0.58 | 0.32 | 0.83 |
| g__Campylobacter | 18.33 | 16.00 | 0.30 | 15.32 | 15.00 | 0.43 | 0.76 | 0.44 | 0.11 | 0.36 |
| f__Saccharimonadaceae-1 | 14.54 | 16.00 | 0.56 | 12.20 | 15.00 | 0.66 | 1.30 | 0.85 | 0.15 | 0.53 |
| f__Saccharimonadaceae-2 | 31.32 | 22.00 | 0.09 | 31.32 | 21.00 | 0.07 | –0.01 | 0.98 | 0.99 | 0.10 |
| f__Saccharimonadaceae-3 | 8.71 | 15.00 | 0.89 | 8.53 | 14.00 | 0.86 | 0.56 | 1.32 | 0.68 | 0.93 |