Fig.1.
Fig. 2.
Fig. 3.
Fig. 4.
Sensitivity analysis results of the MR study for PLC_
| Exposure | Heterogeneity analysis | Pleiotropy analysis | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Inverse variance weighted | MR Egger | MR Egger | MR PRESSO global test | |||||||
| Q | Q_df | Q_pval | Q | Q_df | Q_pval | Egger_ intercept | se | pval | pval | |
| g__TM7x | 14.15 | 15.00 | 0.51 | 14.11 | 14.00 | 0.44 | –0.20 | 1.01 | 0.84 | 0.50 |
| g__Streptococcus-1 | 13.55 | 14.00 | 0.48 | 13.54 | 13.00 | 0.41 | 0.05 | 0.58 | 0.93 | 0.56 |
| s__Fusobacterium_periodonticum-1 | 12.79 | 21.00 | 0.92 | 12.27 | 20.00 | 0.91 | –0.62 | 0.86 | 0.48 | 0.93 |
| s__Streptococcus_gordonii | 17.85 | 14.00 | 0.21 | 17.36 | 13.00 | 0.18 | –1.19 | 1.97 | 0.56 | 0.29 |
| s__Streptococcus-2 | 11.94 | 17.00 | 0.80 | 11.65 | 16.00 | 0.77 | –0.41 | 0.78 | 0.60 | 0.83 |
| g__Solobacterium | 14.12 | 15.00 | 0.52 | 14.05 | 14.00 | 0.45 | –0.22 | 0.83 | 0.80 | 0.56 |
| s__Capnocytophaga_sputigena | 8.40 | 16.00 | 0.94 | 8.40 | 15.00 | 0.91 | –0.04 | 1.27 | 0.97 | 0.96 |
| s__Fusobacterium_periodonticum-2 | 15.97 | 20.00 | 0.72 | 15.93 | 19.00 | 0.66 | 0.19 | 0.95 | 0.85 | 0.75 |
| s__Streptococcus-3 | 17.36 | 20.00 | 0.63 | 16.08 | 19.00 | 0.65 | 1.51 | 1.34 | 0.27 | 0.65 |
| s__Haemophilus | 8.52 | 13.00 | 0.81 | 7.46 | 12.00 | 0.83 | 0.60 | 0.58 | 0.32 | 0.83 |
| g__Campylobacter | 18.33 | 16.00 | 0.30 | 15.32 | 15.00 | 0.43 | 0.76 | 0.44 | 0.11 | 0.36 |
| f__Saccharimonadaceae-1 | 14.54 | 16.00 | 0.56 | 12.20 | 15.00 | 0.66 | 1.30 | 0.85 | 0.15 | 0.53 |
| f__Saccharimonadaceae-2 | 31.32 | 22.00 | 0.09 | 31.32 | 21.00 | 0.07 | –0.01 | 0.98 | 0.99 | 0.10 |
| f__Saccharimonadaceae-3 | 8.71 | 15.00 | 0.89 | 8.53 | 14.00 | 0.86 | 0.56 | 1.32 | 0.68 | 0.93 |