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Comparative Analysis of Microbiological Profiles and Antibiotic Resistance Genes in Subjects with Colorectal Cancer and Healthy Individuals Cover

Comparative Analysis of Microbiological Profiles and Antibiotic Resistance Genes in Subjects with Colorectal Cancer and Healthy Individuals

Open Access
|Mar 2025

Figures & Tables

Fig. 1.

Comparison of GIT microbial relative abundance at the phylum, genus and species level between CRC patients and healthy subjects. CRC – colorectal cancer, GIT – gastrointestinal tract
Comparison of GIT microbial relative abundance at the phylum, genus and species level between CRC patients and healthy subjects. CRC – colorectal cancer, GIT – gastrointestinal tract

Fig. 2.

Analysis of metabolic function between CRC – colorectal cancer patients and healthy subjects.
A) Histogram of intestinal microbiota metabolism and functional gene relative abundance in patients with CRC and healthy controls; B) analysis of similarity in each group or between the two groups; C) relative abundance comparison in CRC patients and healthy controls.
Analysis of metabolic function between CRC – colorectal cancer patients and healthy subjects. A) Histogram of intestinal microbiota metabolism and functional gene relative abundance in patients with CRC and healthy controls; B) analysis of similarity in each group or between the two groups; C) relative abundance comparison in CRC patients and healthy controls.

Fig. 3.

Analysis of resistant genes between CRC patients and healthy subjects.
A) Histogram of intestinal microbiota ARG relative abundance in patients with CRC and healthy controls; B) analysis of similarity in each group or between the two groups; C) comparison of intestinal microbiota ARGs between CRC patients and healthy controls. ARG – antibiotic resistance genes, CRC – colorectal cancer
Analysis of resistant genes between CRC patients and healthy subjects. A) Histogram of intestinal microbiota ARG relative abundance in patients with CRC and healthy controls; B) analysis of similarity in each group or between the two groups; C) comparison of intestinal microbiota ARGs between CRC patients and healthy controls. ARG – antibiotic resistance genes, CRC – colorectal cancer

Fig. 4.

Multivariate analysis of metabolic functions and resistant genes in CRC patients and healthy controls. CRC – colorectal cancer, LDA – linear discriminant analyse
Multivariate analysis of metabolic functions and resistant genes in CRC patients and healthy controls. CRC – colorectal cancer, LDA – linear discriminant analyse

Fig. 5.

Comparison of Actinobacteria at the A) order, B) family, C) genus and D) species level in CRC patients and the healthy control group. CRC – colorectal cancer
Comparison of Actinobacteria at the A) order, B) family, C) genus and D) species level in CRC patients and the healthy control group. CRC – colorectal cancer

Baseline characteristics of healthy controls and CRC patients_

Subject codeAge (years), average (range)*SexWeight (kg)Height (cm)Cancer historyMedical historyDiagnosis
Healthy controlsZJPQ67 (44–71)Male75167N/AN/AN/A
SKZLMale74172N/AN/AN/A
LJQMale74178N/AN/AN/A
LDGLMale75178N/AN/AN/A
HMXLMale86182N/AN/AN/A
DHBLMale73167N/AN/AN/A
CRC patientsLYZ.157 (42–67)Male59170NoNoneCRC with liver metastasis for 1 month
ANJ.1Male70165NoNoneCRC with liver metastasis for half month
LXL.1Female58160NoHypertensionCRC
MYL.1Female57157NoNoneCRC
XHM.1Female56156NoNoneCRC with cervical lymph node metastasis for 5 days
GWX.1Male90168NoNoneCRC with multiple metastases for 5 days
WZL.1Male73172NoNoneCRC with multiple metastases for 1 month
DOI: https://doi.org/10.33073/pjm-2025-006 | Journal eISSN: 2544-4646 | Journal ISSN: 1733-1331
Language: English
Page range: 71 - 81
Submitted on: Sep 19, 2024
Accepted on: Jan 21, 2025
Published on: Mar 26, 2025
Published by: Polish Society of Microbiologists
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2025 Jun Li, Yanyun Zhu, Qing Chang, Yuan Gong, Jun Wan, Shiping Xu, published by Polish Society of Microbiologists
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.