3-(2-Heteroaryl)-pyrazolotetrazoles – a subunits for losartan-like structures
Open Access
|Dec 2012Abstract
A modification of biphenylyltetrazole moiety of Losartan (A) by 3-(2-heteroaryl)-pyrazolotetrazole (B) is described. Ketone semicarbazones react with two moles of phosphorus oxychloride-dimethylformamide with the formation of 3-substituted pyrazol-4-carbaldehydes. The transformations of 3-substituted pyrazole-4- carboxaldehydes to 3-substituted pyrazole-4-nitriles were carried out by reaction of hydroxylamine in DMFA. The prepared cyano pyrazoles were converted to tetrazoles by heating with trimethylsilylazide and dibuthyltinoxide in toluene.
Language: English
Page range: 220 - 224
Published on: Dec 14, 2012
Published by: Slovak University of Technology in Bratislava
In partnership with: Paradigm Publishing Services
Publication frequency: 1 issue per year
Related subjects:
© 2012 Anita Andicsová, Angelika Lásiková, Marek Fronc, Jozef Kožíšek, Daniel Végh, published by Slovak University of Technology in Bratislava
This work is licensed under the Creative Commons License.