Stimuli responsive polymeric nanoparticles in regulated drug delivery for cancer

Deepak Yadav; Suruchi Suri; Anis Chaudhary; Hemant; Mohd Beg; Veena Garg; Mohd Asif; Altaf Ahmad

doi:10.2478/v10026-012-0060-y

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Stimuli responsive polymeric nanoparticles in regulated drug delivery for cancer

Green Sciences

Volume 14 (2012): Issue 1 (March 2012)

By: Deepak Yadav, Suruchi Suri, Anis Chaudhary, Hemant, Mohd Beg, Veena Garg, Mohd Asif and Altaf Ahmad

Open Access

|Apr 2012

Abstract

Stimuli-responsive drug delivery system is a concept in which a drug is delivered at a suitable rate in response to stimuli. States of diseases may cause an alteration in some parameters of the body (e.g. in tumors) and the onset and offset of the drug delivery can be done by using this as a stimuli or a "trigger". Stimuli-responsive ("intellectual" or "sharp") resources and molecules show abrupt property changes in response to miniature changes in external stimuli such as pH, temperature etc. For regulated drug delivery, environmental stimuli such as pH and temperature, which undertake phase transition in polymer system, have been investigated. Thermally-responsive polymers can be tuned to a preferred temperature variety by copolymerization with a hydrophilic co-monomer or a hydrophobic co-monomer. Hydrophilic co-monomers increase the LCST while hydrophobic co-monomers decrease the LCST. The stimuli responsive polymer for regulated drug delivery can contain a polymer and copolymers having equilibrium of hydrophilic and hydrophobic groups. A number of these polymers have been investigated extensively and some success in drug delivery with them has been achieved, such as polymers and copolymers of N-isopropylacrylamide, PLGA, and PLA, HEMA etc. Thus this review is designed for stimuli pH and temperature responsive polymeric nanoparticles, which would be helpful to treat various cronic diseases such as cancer and others, for scientists in the field of the regulated drug delivery system.

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Articles in this issue

DOI: https://doi.org/10.2478/v10026-012-0060-y | Journal eISSN: 3072-0389 (formerly 1899-4741) | Journal ISSN: 1509-8117

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Language: English

Page range: 57 - 64

Published on: Apr 3, 2012

Published by: West Pomeranian University of Technology, Szczecin

In partnership with: Paradigm Publishing Services

Publication frequency: Volume open

Keywords:

Regulated drug delivery,

temperature and pH sensitive nanoparticles,

polymeric Micelles,

cancer

Related subjects:

Industrial chemistry,

Biotechnology,

Chemical engineering,

Process engineering

© 2012 Deepak Yadav, Suruchi Suri, Anis Chaudhary, Hemant, Mohd Beg, Veena Garg, Mohd Asif, Altaf Ahmad, published by West Pomeranian University of Technology, Szczecin
This work is licensed under the Creative Commons License.

Volume 14 (2012): Issue 1 (March 2012)