New steroidal derivatives synthesized using 3β-hydroxyandrosten-17-one as starting material

Abd El-Latif, Nehad; Abdulla, Mohamed; Amr, Abd

doi:10.2478/v10007-007-0044-2

Abstract

In this study, we synthesized some new substituted steroidal derivatives using 3β-hydroxyandrosten-17-one (dehydroepiandrosterone) as starting material. The synthesized steroidal derivatives 1-11 were evaluated for their androgenic-anabolic activities compared to testosterone as positive control. Details of the synthesis, spectroscopic data and toxicity (LD₅₀) of synthesized compounds are reported.

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New steroidal derivatives synthesized using 3β-hydroxyandrosten-17-one as starting material

Abstract

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