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Synthesis and biological evaluation of thieno[2,3-d]pyrimidine derivatives for anti-inflammatory, analgesic and ulcerogenic activity Cover

Synthesis and biological evaluation of thieno[2,3-d]pyrimidine derivatives for anti-inflammatory, analgesic and ulcerogenic activity

Open Access
|Dec 2007

References

  1. D. J. Brown, Pyrimidines and Their Benzo Derivatives, in Comprehensive Heterocyclic Chemistry (Ed. A. R. Katritzky and C. W. Rees), Vol. 3, Pergamon Press, Oxford 1984, p. 443.10.1016/B978-008096519-2.00035-7
  2. B. Roth and C. Cheng, Diaminopyrimidines, in Progress in Medicinal Chemistry (Eds. G. B. Ellis and G. E. West), Vol. 19, Elsevier Biomedical Press, New York 1982, p. 267.
  3. M. S. A. E.-A. El-Gaby, S. G. Abdel-Hamide, M. M. Ghorab and S. M. El-Sayed, Synthesis and anticancer activity in vitro of some new pyrimidines, Acta Pharm.49 (1999) 149-158.
  4. C. R. Petrie, H. B. Cottam, P. A. Mckernan, R. K. Robins and G. R. Revankar, Synthesis and biological activity of 6-azacadeguomycin and certain 2,4,6-trisubstituted pyrazolo[3,4-d]-pyrimidine ribonucleosides, J. Med. Chem.28 (1985) 1010-1016.10.1021/jm00146a007
  5. M. N. Nasr and M. M. Gineinah, Pyrido[2,3-d]pyrimidines and pyrimido[5',4':5,6]-pyrido[2,3-d] pyrimidines as new antiviral agents: Synthesis and biological activity, Arch. Pharm.335 (2002) 289-295; DOI: 10.1002/1521-4184(200208)335:6 289.
  6. P. G. Baraldi, M. G. Pavani, M. Nunez, P. Brigidi, B. Vitali, R. Gambari and R. Romagnoli, Antimicrobial and antitumor activity of N-heteroimine-1,2,3-diathiazoles and their transformation in triazolo-, imidazo- and pyrazolopyrimidines, Bioorg. Med. Chem.10 (2002) 449-456; DOI: 10.1016/S0968-0896(01)00294-2.10.1016/S0968-0896(01)00294-2
  7. S. M. Sondhi, M. Johar, S. Rajvanshi, S. G. Dastidar, R. Shukla, R. Raghubir and J. W. Lown, Anticancer, anti-inflammatory and analgesic activity evaluation of heterocyclic compounds synthesized by the reaction of 4-isothiocyanato-4-methylpentan-2-one with substituted o-phenylenediamines, o-diaminopyridine and (un)substituted o-diamino-pyrimidines, Australian J. Chem.54 (2001) 69-74; DOI: 10.1071/CH00141.10.1071/CH00141
  8. A. Z. M. S. Chowdhury, M. M. Matin and M. N. Anwar, Synthesis and antimicrobial activities of fused pyrimidines: Benzothieno[2,3-d]imidazol[1,2-c]pyrimidine, Chittagong Univ. Stud. Part II21 (1997) 79-83; ref Chem. Abstr.130 (1999) 237530p.
  9. A. M. Abdel-Fattah, A. S. Aly, F. A. Gad, M. E. A. Zaki and A. B. A. El-Gazzar, A facile synthesis of isooxazolo[5,4:4',5']thiazolo[3,2-a]thienopyrimidines, a new ring system, Phosphorus Sulfur141 (1998) 263-281; DOI: 10.1080/10426509808033738.10.1080/10426509808033738
  10. A. M. Abdel-Fattah, A. S. Aly, F. A. Gad, N. A. Hassan and A. B. A. El-Gazzar, Synthesis and reaction of polynuclear heterocycles, with a new ring system, Phosphorus Sulfur163 (2000) 1-27; DOI: 10.1080/10426500008046607.10.1080/10426500008046607
  11. A. K. Gewald, E. Schinke and H. Bottcher, 2-Amino-thiophene aus methylenaktiven Nitrilen, Carbonylverbindungen und Schwefel, Chem. Ber.99 (1966) 94-100.10.1002/cber.19660990116
  12. P. Wolkoff, T. S. Nemeth and S. M. Gibson, Reaction of hydrazonyl halides with derivatives of thiourea and thiosemicarbazide; A new source of C-amino- and C-hydrazino-1,2,4-triazoles, Can. J. Chem.53 (1975) 3211-3215.10.1139/v75-458
  13. A. F. Hegarty, M. Cashoman, J. B. Aylward and F. L. Scott, Ortho-group participation in azocarbonium ion and 1,3-dipolar ion formation, J. Chem. Soc. B57 (1971) 1879-1883.10.1039/j29710001879
  14. Guide to the Care and Use of Experimental Animals, Vol. 1, 2nd ed. (Eds. E. D. Olfert, B. M. Cross and A. A. McWilliam), Canadian Council of Animal Care, Ottawa 1993.
  15. C. A. Winter, E. A. Risley and G. W. Nuss, Carrageenin-induced edema in hind paw of the rats as an assay anti-inflammatory drugs, Proc. Soc. Exp. Biol. Med.III (1962) 544-547.10.3181/00379727-111-2784914001233
  16. J. Miño, V. Moscatelli, O. Hnatyszyn, S. Gorzalczany, C. Acevedo and G. Ferraro, J. Pharmacol. Res.50 (2004) 59-63; DOI: 10.1016/j.phrs.2003.12.016.10.1016/j.phrs.2003.12.01615082030
  17. H. D. J. Collier, L. C. Dinnin, C. A. Johnson and C. Schneider., The abdominal response and its suppression by analgestic drugs in the mouse Br. J. Pharmacol. Chemother.32 (1968) 295-310.
  18. R. K. Goel, A. Chakrabarthi and A. K. Sanyal, Planta Med.29 (1985) 85-88.10.1055/s-2007-9694124034739
  19. H. Shay, S. A. Komarav, S. E. Fels, D. Meraza, M. Gruenstein and H. Siplet, Gastroenterology5 (1994) 43-61.
  20. A. K. Ganguly and O. P. Bhatnagar, Can. J. Physiol. Pharmacol.51 (1973) 748-750.10.1139/y73-1134753287
  21. A. M. Abdel-Fattah, A. S. Aly, F. Abdel-Motti, N. A. Hassan and H. A. Aly, Synthesis and reaction of some thienopyrimidine derivatives and some of photooxidation, Egyptian J. Chem.38 (1995) 627-633.
  22. A. S. Aly, A. B. A. El-Gazzar and H. A. R. Hussien, Synthesis and reactions of polynuclear heterocycles: Azolothienopyrimidines and thienothiazolopyrimidines, Phosphorus Sulfur181 (2006) 2771-2784; DOI: 10.1080/10426500600865293.10.1080/10426500600865293
  23. A. B. A. El-Gazzar, H. A. R. Hussien and A. S. Aly, Synthesis of some derivatives derived from 1,2,3,4-tetrahydrocyclo-hepteno[4,5]thieno[2,3-d]pyrimidine, Phosphorus Sulfur182 (2007) 35-56; DOI: 10.1080/10426500600864536.10.1080/10426500600864536
  24. B. Cacciari and G. Spalluto, Facile and versatile route to the synthesis of fused 2-pyridones: Useful intermediates for polycyclic systems, Synthetic Commun.36 (2006) 1177-1183; DOI: 10.1080/00397910500514063.10.1080/00397910500514063
DOI: https://doi.org/10.2478/v10007-007-0032-6 | Journal eISSN: 1846-9558 | Journal ISSN: 1330-0075
Language: English
Page range: 395 - 411
Published on: Dec 28, 2007
Published by: Croatian Pharmaceutical Society
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year
Related subjects:

© 2007 Abdel-Rahman El-Gazzar, Hoda Hussein, Hend Hafez, published by Croatian Pharmaceutical Society
This work is licensed under the Creative Commons License.

Volume 57 (2007): Issue 4 (December 2007)