Synthesis and biological evaluation of thieno[2,3-d]pyrimidine derivatives for anti-inflammatory, analgesic and ulcerogenic activity

Abdel-Rahman El-Gazzar; Hoda Hussein; Hend Hafez

doi:10.2478/v10007-007-0032-6

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Synthesis and biological evaluation of thieno[2,3-d]pyrimidine derivatives for anti-inflammatory, analgesic and ulcerogenic activity

Acta Pharmaceutica

Volume 57 (2007): Issue 4 (December 2007)

By: Abdel-Rahman El-Gazzar, Hoda Hussein and Hend Hafez

Open Access

|Dec 2007

Abstract

5-Methyl-6-phenyl-2-thioxothieno[2,3-d]pyrimidone derivative (2) reacted with hydrazonoyl chloride derivatives to afford triazolothienopyrimidones 4a-f. Also, acetone-1-(2-amino-5-isopropyl-thiophene-3-carbonitrile) (3) reacted with functional and bifunctional groups to yield the corresponding compounds 5-11. The new products showed anti-inflammatory, analgesic, and ulcerogenic activities comparable to that of indomethacin and acetylsalicylic acid, respectively.

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Articles in this issue

DOI: https://doi.org/10.2478/v10007-007-0032-6 | Journal eISSN: 1846-9558 | Journal ISSN: 1330-0075

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Language: English

Page range: 395 - 411

Published on: Dec 28, 2007

Published by: Croatian Pharmaceutical Society

In partnership with: Paradigm Publishing Services

Publication frequency: 4 issues per year

Keywords:

triazolothienopyrimidine,

thienopyrimidines,

thieno[2,3-d][1,3]thiazine,

Related subjects:

© 2007 Abdel-Rahman El-Gazzar, Hoda Hussein, Hend Hafez, published by Croatian Pharmaceutical Society
This work is licensed under the Creative Commons License.

Volume 57 (2007): Issue 4 (December 2007)