Abstract
Osteoarthritis (OA) of the knee (gonarthrosis) is a degenerative rheumatic disease, which is the most common rheumatic disease. Numerous factors, such as mechanical, enzymatic, and biological, are responsible for the development of this complex, multifactorial disease. The connection between inflammation and the development of knee OA is being investigated more and more. Cytokines are thought to be one of the main causes of disturbances in normal cartilage metabolism.
This study, designed as a prospective cohort study included 60 patients with knee OA. The examinees were recruited from total population of patients with knee OA, hospitalized or treated as outpatients at Department of Physical Medicine and Rehabilitation, University Clinical Centre Kragujevac. After the consent was obtained, anamnestic data were collected, blood samples were taken and functional testing was done together with anthropometric measurements. The values of the following cytokines were determined from a blood sample: IL-6, TNF-α, IL-10, IL-17. The average age of patients was 69.10±9.06 years, most of whom were females (78,3%). Both IL-6 and TNF-α correlated positively with WOMAC scores. WOMAC index subscales showed different association with cytokines. In our studies the level of cytocines in the serum of pacients with OA knee is show not correlation with radiographic image.
The present study demonstrated than the concentrations of proinflammatory cytokines (TNF-α IL-6) can be correlated with WOMAC scores of knee OA patients. The results indicate that concentrations of TNF-α and IL-6 may affect knee joint function in patients with knee OA.