Role of IL-33 and IL-35 in the Pathogenesis of Rheumatoid Arthritis

Jasmina Jocic; Sladjana Pavlovic; Aleksandra Tomic Lucic

doi:10.2478/sjecr-2022-0037

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Role of IL-33 and IL-35 in the Pathogenesis of Rheumatoid Arthritis

EABR. Experimental and Applied Biomedical Research

AHEAD OF PRINT

By: Jasmina Jocic, Sladjana Pavlovic and Aleksandra Tomic Lucic

Open Access

|Jan 2023

Abstract

Cytokine-mediated immunity plays an important role in the pathogenesis of the rheumatoid arthritis. Interleukins IL-33 and IL-35 are closely associated with various rheumatic diseases. The effect of IL-33 on rheumatoid arthritis is believed to be mediated by induction of proinflammatory cytokines (IFN-γ, TNF-α, and IL-17), activation of mast cell degranulation, and mobilization of neutrophils in the joints. However, in addition to the pro-inflammatory, its anti-inflammatory role in rheumatic diseases has also been noticed. The potential mechanism of its anti-inflammatory action can be explained by IL-33-induced mast cell activation that can affect rheumatoid arthritis. IL-35 is a heterodimeric protein and has a significant anti-inflammatory effect. This inhibitory cytokine can express its therapeutic potential through the suppression of osteoclastogenesis and angiogenesis. This review presents current knowledge on the role of these cytokines in the pathogenesis of rheumatoid arthritis.

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Articles in this issue

DOI: https://doi.org/10.2478/sjecr-2022-0037 | Journal eISSN: 2956-2090 (formerly 2335-075X, 2956-0454) | Journal ISSN: 2956-0454 (formerly 1820-8665)

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Language: English

Submitted on: Jan 23, 2022

Accepted on: Mar 16, 2022

Published on: Jan 27, 2023

Published by: University of Kragujevac, Faculty of Medical Sciences

In partnership with: Paradigm Publishing Services

Keywords:

IL-33,

IL-35,

rheumatoid arthritis

Related subjects: