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Mesenchymal Stem Cells Versus Covid-19. Can they Win the Battle? Cover

Figures & Tables

MSC-based ongoing clinical trials for Covid-19 infection diseases

Study Name:Mesenchymal Stem Cell Infusion for COVID-19 Infection (NCT04444271)
Status:Recruiting (Phase II)
Treatment:MSC

Study Name:Mesenchymal Stem Cell for Acute Respiratory Distress Syndrome Due for COVID-19 (NCT04416139)
Status:Recruiting (Phase II)
Treatment:MSC

Study Name:Mesenchymal Stem Cells Therapy in Patients With COVID-19 Pneumonia (NCT04713878)
Status:Completed
Treatment:MSC

Study Name:Safety and Efficacy of Mesenchymal Stem Cells in the Management of Severe COVID-19 Pneumonia (NCT04429763)
Status:Not yet recruiting (Phase II)
Treatment:UC-MSC

Study Name:Cord Blood-Derived Mesenchymal Stem Cells for the Treatment of COVID-19 Related Acute Respiratory Distress Syndrome (NCT04565665)
Status:Recruiting (Phase I)
Treatment:MSC

Study Name:NestaCell® Mesenchymal Stem Cell to Treat Patients With Severe COVID-19 (NCT04315987)
Status:Not yet recruiting (Phase II)
Treatment:MSCs (NestaCell®)

Study Name:Mesenchymal Stem Cells in Patients Diagnosed With COVID-19 (NCT04611256)
Status:Recruiting(Phase I)
Treatment:MSC

Study Name:Use of Mesenchymal Stem Cells in Acute Respiratory Distress Syndrome Caused by COVID-19 (NCT04456361)
Status:Early Phase I
Treatment:WJ-MSC

Study Name:Efficacy of Infusions of MSC From Wharton Jelly in the SARS-Cov-2 (COVID-19) Related Acute Respiratory Distress Syndrome (NCT04625738)
Status:Not yet recruiting (Phase II)
Treatment:WJ-MSC

Study Name:Mesenchymal Stem Cell Treatment for Pneumonia Patients Infected With COVID-19 (NCT04252118)
Status:Recruiting(Phase I)
Treatment:MSCs

Study Name:Clinical Trial of Allogeneic Mesenchymal Cells From Umbilical Cord Tissue in Patients With COVID-19 (NCT04366271)
Status:Recruiting (Phase II)
Treatment:WJ-MSC

Study Name:Treatment of COVID-19 Patients Using Wharton’s Jelly-Mesenchymal Stem Cells (NCT04313322)
Status:Recruiting(Phase I)
Treatment:
  • Use of Stem Cells for COVID-19 Treatment

  • WJ-MSCs


Study Name:Clinical Trial to Assess the Safety and Efficacy of Intravenous Administration of Allogeneic Adult Mesenchymal Stem Cells of Expanded Adipose Tissue in Patients With Severe Pneumonia Due to COVID-19 (NCT04366323)
Status:Active, not recruiting (Phase II)
Treatment:AT-MSC

Study Name:Treatment of Severe COVID-19 Patients Using Secretome of Hypoxia-Mesenchymal Stem Cells in Indonesia (NCT04753476)
Status:Recruiting (Phase II)
Treatment:Injection of Secretome-MSCs

Study Name:Safety and Efficacy Study of Allogeneic Human Dental Pulp Mesenchymal Stem Cells to Treat Severe COVID-19 Patients (NCT04336254)
Status:Recruiting (Phase I, II)
Treatment:Allogeneic human dental pulp stem cells (BSH BTC & Utooth BTC)|

Study Name:Bone Marrow-Derived Mesenchymal Stem Cell Treatment for Severe Patients With Coronavirus Disease 2019 (COVID-19) (NCT04346368)
Status:Not yet recruiting (Phase I, II)
Treatment:BM-MSCs

Study Name:Treatment With Human Umbilical Cord-derived Mesenchymal Stem Cells for Severe Corona Virus Disease 2019 (COVID-19) (NCT04288102)
Status:Completed (Phase II)
Treatment:UC-MSCs

Study Name:Study to Evaluate the Efficacy and Safety of AstroStem-V in Treatment of COVID-19 Pneumonia (NCT04527224)
Status:Not yet recruiting (Phase I, II)
Treatment:Adipose tissue-derived mesenchymal stem cells (AstroStem-V)

Study Name:Regenerative Medicine for COVID-19 and Flu-Elicited ARDS Using Longeveron Mesenchymal Stem Cells (LMSCs) (NCT04629105)
Status:Recruiting (Phase I)
Treatment:Longeveron Mesenchymal Stem Cells (LMSCs)

Study Name:Study of Human Umbilical Cord Mesenchymal Stem Cells in the Treatment of Severe COVID-19 (NCT04273646)
Status:Not yet recruiting
Treatment:UC-MSCs

Study Name:Study of Intravenous Administration of Allogeneic Adipose-Derived Mesenchymal Stem Cells for COVID-19-Induced Acute Respiratory Distress (NCT04728698)
Status:Not yet recruiting (Phase II)
Treatment:COVI-MSC

Study Name:A Randomized, Double-Blind, Placebo-Controlled Clinical Trial to Determine the Safety and Efficacy of Hope Biosciences Allogeneic Mesenchymal Stem Cell Therapy (HB-adMSCs) to Provide Protection Against COVID-19 (NCT04348435)
Status:Enrolling by invitation (Phase II)
Treatment:HB-adMSCs

Study Name:Treatment of Covid-19 Associated Pneumonia With Allogenic Pooled Olfactory Mucosa-derived Mesenchymal Stem Cells (NCT04382547)
Status:Enrolling by invitation (Phase I,II)
Treatment:Allogenic pooled olfactory mucosa-derived MSC

Study Name:Clinical Research of Human Mesenchymal Stem Cells in the Treatment of COVID-19 Pneumonia (NCT04339660)
Status:Recruiting(Phase I,II)
Treatment:UC-MSCs

Study Name:Expanded Access Protocol on Bone Marrow Mesenchymal Stem Cell Derived Extracellular Vesicle Infusion Treatment for Patients With COVID-19 Associated ARDS (NCT04657458)
Status:Phase I
Treatment:BM-MSC Derived Extracellular Vesicles Infusion Treatment

Study Name:
  • Mesenchymal Stem Cell Therapy for SARS-CoV-2-related Acute Respiratory Distress Syndrome

  • (NCT04366063)

Status:Recruiting(Phase II,III)
Treatment:Cell therapy protocol

Study Name:Autologous Adipose-derived Stem Cells (AdMSCs) for COVID-19 (NCT04428801)
Status:Not yet recruiting(Phase II)
Treatment:Autologous adipose-derived stem cells

Study Name:Administration of Allogenic UC-MSCs as Adjuvant Therapy for Critically-Ill COVID-19 Patients (NCT04457609)
Status:Recruiting (Phase I)
Treatment:Oseltamivir| UC-MSC

Study Name:A Clinical Trial to Determine the Safety and Efficacy of Hope Biosciences Autologous Mesenchymal Stem Cell Therapy (HB-adMSCs) to Provide Protection Against COVID-19 (NCT04349631)
Status:Active, not recruiting (Phase II)
Treatment:HB-adMSCs

Study Name:Adipose Mesenchymal Cells for Abatement of SARS-CoV-2 Respiratory Compromise in COVID-19 Disease (NCT04352803)
Status:Not yet recruiting(Phase I)
Treatment:Autologous Adipose MSC’s

Study Name:Mesenchymal Stem Cells for the Treatment of COVID-19 (NCT04573270)
Status:Completed(Phase I)
Treatment:UC-MSC (PrimePro)

Study Name:Novel Coronavirus Induced Severe Pneumonia Treated by Dental Pulp Mesenchymal Stem Cells (NCT04302519)
Status:Not yet recruiting(Phase I)
Treatment:Dental pulp MSC

Study Name:Umbilical Cord Tissue (UC) Derived Mesenchymal Stem Cells (MSCs) Versus Placebo to Treat Acute Pulmonary Inflammation Due to COVID-19 (NCT04490486)
Status:Not yet recruiting(Phase I)
Treatment:UCMSCs

Study Name:Use of UC-MSCs for COVID-19 Patients (NCT04355728)
Status:Completed (Phase I,II)
Treatment:Umbilical Cord Mesenchymal Stem Cells + Heparin along with best supportive care.

Study Name:An Exploratory Study of ADR-001 in Patients With Severe Pneumonia Caused by SARS-CoV-2 Infection (NCT04522986)
Status:Not yet recruiting (Phase I)
Treatment:MSC

Study Name:Treatment of Coronavirus COVID-19 Pneumonia (Pathogen SARS-CoV-2) With Cryopreserved Allogeneic P_MMSCs and UC-MMSCs (NCT04461925)
Status:Recruiting (Phase I,II)
Treatment:Placenta-Derived MMSCs; Cryopreserved Placenta-Derived Multipotent Mesenchymal Stromal Cells

Study Name:Safety and Effectiveness of Mesenchymal Stem Cells in the Treatment of Pneumonia of Coronavirus Disease 2019 (NCT04371601)
Status:Active, not recruiting (Phase I)
Treatment:Oseltamivir mesenchymal stem cells

Study Name:BAttLe Against COVID-19 Using MesenchYmal Stromal Cells (NCT04348461)
Status:Not yet recruiting (Phase II)
Treatment:Allogeneic and expanded adipose tissue-derived Mesenchymal stromal cells

Study Name:Efficacy and Safety Study of Allogeneic HB-adMSCs for the Treatment of COVID-19 (NCT04362189)
Status:Active, not recruiting (Phase II)
Treatment:HB-adMSC

Study Name:Therapeutic Study to Evaluate the Safety and Efficacy of DW-MSC in COVID-19 Patients (NCT04535856)
Status:Completed(Phase I)
Treatment:Allogeneic mesenchymal stem cell

Study Name:Therapy for Pneumonia Patients iInfected by 2019 Novel Coronavirus (NCT04293692)
Status:Withdrawn
Treatment:UC-MSCs

Study Name:Safety and Efficacy of Intravenous Wharton’s Jelly Derived Mesenchymal Stem Cells in Acute Respiratory Distress Syndrome Due to COVID 19 (NCT04390152)
Status:Recruiting (Phase I,II)
Treatment:WJ-MSC

Study Name:Study of the Safety of Therapeutic Tx With Immunomodulatory MSC in Adults With COVID-19 Infection Requiring Mechanical Ventilation (NCT04397796)
Status:Recruiting(Phase I)
Treatment:BM-Allo.MSC

Study Name:A Phase II Study in Patients With Moderate to Severe ARDS Due to COVID-19 (NCT04780685)
Status:Recruiting (Phase II)
Treatment:hMSC

Study Name:Umbilical Cord Lining Stem Cells (ULSC) in Patients With COVID-19 ARDS (NCT04494386)
Status:Recruiting (Phase I,II)
Treatment:Umbilical Cord Lining Stem Cells (ULSC)

Study Name:Mesenchymal Stem Cells (MSCs) in Inflammation-Resolution Programs of Coronavirus Disease 2019 (COVID-19) Induced Acute Respiratory Distress Syndrome (ARDS) (NCT04377334)
Status:Not yet recruiting (Phase II)
Treatment:MSC

Study Name:Use of hUC-MSC Product (BX-U001) for the Treatment of COVID-19 With ARDS (NCT04452097)
Status:Not yet recruiting(Phase I,II)
Treatment:Human umbilical cord mesenchymal stem cells

Study Name:Mesenchymal Stromal Cells for the Treatment of SARS-CoV-2 Induced Acute Respiratory Failure (COVID-19 Disease) (NCT04345601)
Status:Recruiting (Phase I,II)
Treatment:Mesenchymal Stromal Cells

Study Name:Efficacy and Safety Evaluation of Mesenchymal Stem Cells for the Treatment of Patients With Respiratory Distress Due to COVID-19 (NCT04390139)
Status:Recruiting (Phase I,II)
Treatment:Expanded MSC from Wharton Jelly (XCEL-UMC-BETA)

Study Name:Investigational Treatments for COVID-19 in Tertiary Care Hospital of Pakistan (NCT04492501)
Status:Completed
Treatment:Convalescent Plasma|Drug: Tocilizumab|Drug: Remdesivir|MSC

Study Name:Clinical Use of Stem Cells for the Treatment of Covid-19 (NCT04392778)
Status:Recruiting(Phase I,II)
Treatment:MSC Treatment

Study Name:Safety and Feasibility of Allogenic MSC in the Treatment of COVID-19 (NCT04467047)
Status:Not yet recruiting (Phase I)
Treatment:Mesenchymal Stromal Cells infusion

Study Name:The MEseNchymal coviD-19 Trial: a Pilot Study to Investigate Early Efficacy of MSCs in Adults With COVID-19 (NCT04537351)
Status:Recruiting(Phase I,II)
Treatment:Allogeneic mesenchymoangioblast-derived mesenchymal stem cells (MCA-derived MSCs)- (CYP-001)

Study Name:ACT-20 in Patients With Severe COVID-19 Pneumonia (NCT04398303)
Status:Not yet recruiting(Phase I,II)
Treatment:Allogenic human umbilical derived mesenchymal stem cells (ACT-20-MSC), Allogenic human umbilical derived mesenchymal stem cells in conditioned media (ACT-20-CM)

Study Name:Treatment of Severe COVID-19 Pneumonia With Allogeneic Mesenchymal Stromal Cells (COVID_MSV) (NCT04361942)
Status:Recruiting (Phase II)
Treatment:Mesenchymal Stromal Cells|

Study Name:Repair of Acute Respiratory Distress Syndrome by Stromal Cell Administration (REALIST) (COVID-19) (NCT03042143)
Status:Recruiting(Phase I,II)
Treatment:Human umbilical cord derived CD362 enriched MSCs

Study Name:Umbilical Cord(UC)-Derived Mesenchymal Stem Cells(MSCs) Treatment for the 2019-novel Coronavirus(nCOV) Pneumonia (NCT04269525)
Status:Recruiting(Phase II)
Treatment:UC-MSCs

Study Name:Mesenchymal Stromal Cell Therapy For The Treatment Of Acute Respiratory Distress Syndrome (NCT04447833)
Status:Active, not recruiting(Phase I)
Treatment:Mesenchymal Stromal Stem Cells - KI-MSC-PL-205

Study Name:Efficacy of Intravenous Infusions of Stem Cells in the Treatment of COVID-19 Patients (NCT04437823)
Status:Recruiting(Phase II)
Treatment:Intravenous Infusions of Stem Cells

Study Name:Safety and Efficiency of Method of Exosome Inhalation in COVID-19 Associated Pneumonia (NCT04602442)
Status:Enrolling by invitation(Phase II)
Treatment:Exosome inhalation (EXO 1 inhalation)| (EXO 2 inhalation)

Study Name:Evaluation of Safety and Efficiency of Method of Exosome Inhalation in SARSCoV-2 Associated Pneumonia. (NCT04491240)
Status:Completed(Phase I,II)
Treatment:Exosome inhalation (EXO 1 inhalation)| (EXO 2 inhalation)

Study Name:Cell Therapy Using Umbilical Cord-derived Mesenchymal Stromal Cells in SARSCoV-2-related ARDS (NCT04333368)
Status:Active, not recruiting(Phase I,II)
Treatment:Umbilical cord Wharton’s jelly-derived human Mesenchymal Stromal Cells|

Study Name:MSCs in COVID-19 ARDS (NCT04371393)
Status:Active, not recruiting (Phase III)
Treatment:Expanded mesenchymal stromal cells derived from the bone marrow (Remestemcel-L)

Study Name:Study of Descartes-30 in Acute Respiratory Distress Syndrome (NCT04524962)
Status:Recruiting(Phase I,II)
Treatment:RNA-engineered off-the-shelf allogeneic mesenchymal stem cell MSC (Descartes 30)

Study Name:Multiple Dosing of Mesenchymal Stromal Cells in Patients With ARDS (COVID-19) (NCT04466098)
Status:Recruiting(Phase II)
Treatment:Mesenchymal stromal cells

Study Name:Cellular Immuno-Therapy for COVID-19 Acute Respiratory Distress Syndrome - Vanguard (NCT04400032)
Status:Recruiting(Phase I)
Treatment:Mesenchymal Stromal Cells

Study Name:A Pilot Clinical Study on Inhalation of Mesenchymal Stem Cells Exosomes Treating Severe Novel Coronavirus Pneumonia (NCT04276987)
Status:Completed(Phase I)
Treatment:MSCs-derived exosomes

Study Name:Mesenchymal Stem Cells for the Treatment of Various Chronic and Acute Conditions (NCT04684602)
Status:Recruiting(Phase I,II)
Treatment:Human umbilical chord tissue-derived MSC (PrimePro™/PrimeMSK™)
DOI: https://doi.org/10.2478/sjecr-2021-0024 | Journal eISSN: 2956-2090 | Journal ISSN: 2956-0454
Language: English
Page range: 115 - 130
Submitted on: Mar 23, 2021
|
Accepted on: Apr 3, 2021
|
Published on: Dec 31, 2025
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2025 Amra Ramovic Hamzagic, Dragica Miloradovic, Dragana Miloradovic, Zeljko Ivosevic, Biljana Ljujic, published by University of Kragujevac, Faculty of Medical Sciences
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.