Have a personal or library account? Click to login
Mesenchymal Stem Cells Versus Covid-19. Can they Win the Battle? Cover

Abstract

Mesenchymal stem cells (MSCs) are multipotent stem cells with numerous features potentially useful in various pathologies. It has been shown that MSCs have regenerative potential due to modulation of immune system response, inflammation diminishing, trans differentiation into various types of cells, proangiogenetic and anti fibrotic influence. Besides all of these traits, MSCs posses anti viral capacity and have been further employed in clinical trails since last year. Here, we revised immunomodulatory, biological and antiviral traits of MSCs, but also pathogenesis of Covid-19 and it’s impact on immune system. Conspicuously, there is a grow-ing number of studies examining effect of MSCs in patients suffer-ing from Covid-19 pneumonia and ARDS. Since MSCs are in theo-ry capable of healing lung injury and inflammation, here we dis-cuss hypothesis, pros and cons of MSCs treatment in Covid-19 pa-tients. Finally, we debate if MSCs based therapy can be promising tool for Covid-19 lung pathologies.

DOI: https://doi.org/10.2478/sjecr-2021-0024 | Journal eISSN: 2956-2090 | Journal ISSN: 2956-0454
Language: English
Page range: 115 - 130
Submitted on: Mar 23, 2021
|
Accepted on: Apr 3, 2021
|
Published on: Dec 31, 2025
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2025 Amra Ramovic Hamzagic, Dragica Miloradovic, Dragana Miloradovic, Zeljko Ivosevic, Biljana Ljujic, published by University of Kragujevac, Faculty of Medical Sciences
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.