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Role of IL-33/ST2 Axis in Chronic Inflammatory Neurological Disorderss Cover

References

  1. 1. Schmitz J, Owyang A, Oldham E, Song Y, Murphy E, McClanahan TK, et al. IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. Immunity. 2005; 23: 479–90.10.1016/j.immuni.2005.09.015
  2. 2. Yanagisawa K, Takagi T, Tsukamoto T, Tetsuka T, Tominaga S. Presence of a novel primary response gene ST2L, encoding a product highly similar to the interleukin 1 receptor type 1. FEBS Lett. 1993; 318(1): 83-7.10.1016/0014-5793(93)81333-U
  3. 3. Kuroiwa K, Li H, Tago K, Iwahana H, Yanagisawa K, Komatsu N,et al. Construction of ELISA system to quantify human ST2 protein in sera of patients. Hybridoma. 2000; 19(2): 151-9.10.1089/0272457005003119410868795
  4. 4. Liu X, Hammel M, He Y, Tainer JA, Jeng US, Zhang L, et al. Structural insights into the interaction of IL-33 with its receptors. Proc Natl Acad Sci USA. 2013; 110(37): 14918-23.10.1073/pnas.1308651110377379823980170
  5. 5. Ali S, Huber M, Kollewe C, Bischoff SC, Falk W, Martin MU. IL-1 receptor accessory protein is essential for IL-33-induced activation of T lymphocytes and mast cells. Proc Natl Acad Sci U S A. 2007; 104: 18660–5.10.1073/pnas.0705939104214183318003919
  6. 6. Cayrol C, Girard JP. Interleukin-33 (IL-33): A nuclear cytokine from the IL-1 family. Immunol Rev. 2018; 281(1): 154-168.10.1111/imr.1261929247993
  7. 7. Chackerian AA, Oldham ER, Murphy EE, Schmitz J, Pflanz S, Kastelein RA. IL-1 receptor accessory protein and ST2 comprise the IL-33 receptor complex. J Immunol. 2007; 179: 2551–5.10.4049/jimmunol.179.4.255117675517
  8. 8. Andrade MV, Iwaki S, Ropert C, Gazzinelli RT, Cunha- Melo JR, Beaven MA. Amplification of cytokine production through synergistic activation of NFAT and AP- 1 following stimulation of mast cells with antigen and IL-33. Eur J Immunol. 2011; 41(3): 760-72.10.1002/eji.201040718308525521308681
  9. 9. Dunne A, O’Neill LA. The interleukin-1 receptor/Tolllike receptor superfamily: signal transduction during inflammation and host defense. Sci STKE. 2003; 2003(171):re3.10.1126/stke.2003.171.re312606705
  10. 10. Kakkar R, Hei H, Dobner S, Lee RT. Interleukin 33 as a mechanically responsive cytokine secreted by living cells. J Biol Chem. 2012; 287(9): 6941-8.10.1074/jbc.M111.298703330731322215666
  11. 11. Liew FY, Pitman NI, McInnes IB. Disease-associated functions of IL-33: the new kid in the IL-1 family. Nat Rev Immunol. 2010; 10(2): 103-1010.1038/nri269220081870
  12. 12. Oboki K, Ohno T, Kajiwara N, Arae K, Morita H, Ishii A, et al. IL-33 is a crucial amplifier of innate rather than acquired immunity. Proc Natl Acad Sci U S A. 2010; 107:18581–6.10.1073/pnas.1003059107297296620937871
  13. 13. Kamijo S, Takeda H, Tokura T, Suzuki M, Inui K, Hara M, et al. IL-33-mediated innate response and adaptive immune cells contribute to maximum responses of protease allergen-induced allergic airway inflammation. J Immunol. 2013; 190:4489–9910.4049/jimmunol.120121223547117
  14. 14. Fairlie-Clarke K, Barbour M, Wilson C, Hridi SU, Allan D, Jiang HR. Expression and Function of IL-33/ST2 Axis in the Central Nervous System Under Normal and Diseased Conditions. Front Immunol. 2018; 9:2596.10.3389/fimmu.2018.02596625596530515150
  15. 15. Gadani SP, Walsh JT, Smirnov I, Zheng J, Kipnis J. The glia-derived alarmin IL-33 orchestrates the immune response and promotes recovery following CNS injury. Neuron. 2015; 85:703–9.10.1016/j.neuron.2015.01.01325661185
  16. 16. Yang Y, Liu H, Zhang H, Ye Q, Wang J. ST2/IL-33- dependent microglial response limits acute ischemic brain injury. J Neurosci. 2017; 37:4692–704.10.1523/JNEUROSCI.3233-16.2017542656428389473
  17. 17. Fu AK, Hung KW, Yuen MY, Zhou X, Mak DS, Chan IC, et al. IL-33 ameliorates Alzheimer’s disease-like pathology and cognitive decline. Proc Natl Acad Sci U S A. 2016; 113(19): E2705-13.10.1073/pnas.1604032113486847827091974
  18. 18. Wicher G, Wallenquist U, Lei Y, Enoksson M, Li X, Fuchs B, et al. Interleukin-33 promotes recruitment of microglia/macrophages in response to traumatic brain injury. J Neurotrauma. 2017; 34(22): 3173–82.10.1089/neu.2016.490028490277
  19. 19. Cao K, Liao X, Lu J, Yao S, Wu F, Zhu X, et al. IL- 33/ST2 plays a critical role in endothelial cell activation and microglia-mediated neuroinflammation modulation. J Neuroinflammation. 2018; 15(1): 136.10.1186/s12974-018-1169-6593593629728120
  20. 20. Dohi E, Choi EY, Rose IVL, Murata AS, Chow S, Niwa M, et al. Behavioral Changes in Mice Lacking Interleukin- 33. eNeuro. 2017; 4(6).10.1523/ENEURO.0147-17.2017578805529379874
  21. 21. Vainchtein ID, Chin G, Cho FS, Kelley KW, Miller JG, Chien EC, et al. Astrocyte-derived interleukin-33 promotes microglial synapse engulfment and neural circuit development. Science. 2018; 359(6381): 1269-1273.10.1126/science.aal3589607013129420261
  22. 22. Carlock C, Wu J, Shim J, Moreno-Gonzalez I, Pitcher MR, Hicks J, et al. Interleukin33 deficiency causes tau abnormality and neurodegeneration with Alzheimer-like symptoms in aged mice. Transl Psychiatry. 2017; 7(7): e1164.10.1038/tp.2017.142553812228675392
  23. 23. Pichery M, Mirey E, Mercier P, Lefrancais E, Dujardin A, Ortega N, et al. Endogenous IL-33 is highly expressed in mouse epithelial barrier tissues,lymphoid organs, brain, embryos, and inflamed tissues: in situ analysis using a novel Il-33-LacZ gene trap reporter strain. J Immunol. 2012; 188(7): 3488-95.10.4049/jimmunol.110197722371395
  24. 24. Natarajan C, Yao SY, Sriram S. TLR3 Agonist Poly-IC Induces IL-33 and Promotes Myelin Repair. PLoS One. 2016; 11(3): e0152163.10.1371/journal.pone.0152163481155627022724
  25. 25. Jiang HR, Milovanović M, Allan D, Niedbala W, Besnard AG, Fukada SY, et al. IL-33 attenuates EAE by suppressing IL-17 and IFN-γ production and inducing alternatively activated macrophages. Eur J Immunol. 2012; 42(7): 1804-14.10.1002/eji.20114194722585447
  26. 26. Allan D, Fairlie-Clarke KJ, Elliott C, Schuh C, Barnett SC, Lassmann H, et al. Role of IL-33 and ST2 signalling pathway in multiple sclerosis: expression by oligodendrocytes and inhibition of myelination in central nervous system. Acta Neuropathol Commun. 2016; 4(1): 75.10.1186/s40478-016-0344-1496087727455844
  27. 27. Kempuraj D, Khan MM, Thangavel R, Xiong Z, Yang E, Zaheer A. Glia maturation factor induces interleukin- 33 release from astrocytes: implications for neurodegenerative diseases. J Neuroimmune Pharmacol. 2013; 8(3): 643-50.10.1007/s11481-013-9439-7366041523397250
  28. 28. Glenner GG, Wong CW. Alzheimer’s disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. 1984. Biochem Biophys Res Commun. 2012; 425(3): 534-9.
  29. 29. Heneka MT, Kummer MP, Latz E. Innate immune activation in neurodegenerative disease. Nat Rev Immunol. 2014; 14(7): 463-477.10.1038/nri370524962261
  30. 30. Luterman JD, Haroutunian V, Yemul S, et al. Cytokine gene expression as a function of the clinical progression of Alzheimer disease dementia. Arch Neurol. 2000; 57(8): 1153-1160.10.1001/archneur.57.8.115310927795
  31. 31. Serrano-Pozo A, Mielke ML, Gómez-Isla T, et al. Reactive glia not only associates with plaques but also parallels tangles in Alzheimer’s disease. Am J Pathol. 2011; 179(3): 1373-1384.10.1016/j.ajpath.2011.05.047315718721777559
  32. 32. McGeer PL, McGeer EG. The amyloid cascade-inflammatory hypothesis of Alzheimer disease: implications for therapy. Acta Neuropathol. 2013; 126(4): 479-497.10.1007/s00401-013-1177-724052108
  33. 33. Holmes C, Cotterell D. Role of infection in the pathogenesis of Alzheimer’s disease: implications for treatment. CNS Drugs. 2009; 23(12): 993-1002.10.2165/11310910-000000000-0000019958038
  34. 34. Holmes C. Review: systemic inflammation and Alzheimer’s disease. Neuropathol Appl Neurobiol. 2013; 39(1): 51-68.10.1111/j.1365-2990.2012.01307.x23046210
  35. 35. Su X, Federoff HJ. Immune responses in Parkinson’s disease: interplay between central and peripheral immune systems. Biomed Res Int. 2014; 2014:275178.10.1155/2014/275178400507624822191
  36. 36. Qin L, Wu X, Block ML, et al. Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration. Glia. 2007; 55(5): 453-462.10.1002/glia.20467287168517203472
  37. 37. Erickson MA, Banks WA. Cytokine and chemokine responses in serum and brain after single and repeated injections of lipopolysaccharide: multiplex quantification with path analysis. Brain Behav Immun. 2011; 25(8): 1637-1648.10.1016/j.bbi.2011.06.006338949421704698
  38. 38. Park SM, Choi MS, Sohn NW, Shin JW. Ginsenoside Rg3 attenuates microglia activation following systemic lipopolysaccharide treatment in mice. Biol Pharm Bull. 2012; 35(9): 1546-1552.10.1248/bpb.b12-0039322975507
  39. 39. Biesmans S, Meert TF, Bouwknecht JA, et al. Systemic immune activation leads to neuroinflammation and sickness behavior in mice. Mediators Inflamm. 2013; 2013:271359.10.1155/2013/271359372309323935246
  40. 40. Tremblay MÈ, Stevens B, Sierra A, Wake H, Bessis A, Nimmerjahn A. The role of microglia in the healthy brain. J Neurosci. 2011; 31(45): 16064-16069.10.1523/JNEUROSCI.4158-11.2011663322122072657
  41. 41. Dubois RN, Abramson SB, Crofford L, et al. Cyclooxygenase in biology and disease. FASEB J. 1998; 12(12): 1063-1073.10.1096/fasebj.12.12.1063
  42. 42. Brown GC. Mechanisms of inflammatory neurodegeneration: iNOS and NADPH oxidase. Biochem Soc Trans. 2007; 35(Pt 5): 1119-1121.10.1042/BST0351119
  43. 43. Chapuis J, Hot D, Hansmannel F, Kerdraon O, Ferreira S, Hubans C, et al. Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer’s disease. Mol Psychiatry. 2009; 14(11): 1004-16.10.1038/mp.2009.10
  44. 44. Xiong Z, Thangavel R, Kempuraj D, Yang E, Zaheer S, Zaheer A. Alzheimer’s disease: evidence for the expression of interleukin-33 and its receptor ST2 in the brain. J Alzheimers Dis. 2014; 40(2): 297-308.10.3233/JAD-132081
  45. 45. Yasuoka S, Kawanokuchi J, Parajuli B, Jin S, Doi Y, Noda M, et al. Production and functions of IL-33 in the central nervous system. Brain Res. 2011; 1385:8–17.10.1016/j.brainres.2011.02.045
  46. 46. Marx CE, Jarskog LF, Lauder JM, Lieberman JA, Gilmore JH. Cytokine effects on cortical neuron MAP-2 immunoreactivity: implications for schizophrenia. Biol Psychiatry. 2001; 50:743–749.10.1016/S0006-3223(01)01209-4
  47. 47. Italiani P, Puxeddu I, Napoletano S, et al. Circulating levels of IL-1 family cytokines and receptors in Alzheimer’s disease: new markers of disease progression?. J Neuroinflammation. 2018; 15(1): 342.10.1186/s12974-018-1376-1629217930541566
  48. 48. Richardson JA, Burns DK. Mouse models of Alzheimer’s disease: a quest for plaques and tangles. ILAR J. 2002; 43: 89–99.10.1093/ilar.43.2.8911917160
  49. 49. Saresella M, Marventano I, Piancone F, et al. IL-33 and its decoy sST2 in patients with Alzheimer’s disease and mild cognitive impairment. J Neuroinflammation. 2020; 17(1): 174.10.1186/s12974-020-01806-4727608832505187
  50. 50. Liang CS, Su KP, Tsai CL, et al. The role of interleukin- 33 in patients with mild cognitive impairment and Alzheimer’s disease. Alzheimers Res Ther. 2020; 12(1): 86.10.1186/s13195-020-00652-z736733032678011
  51. 51. Gotz J, Ittner LM. Animal models of Alzheimer’s disease and frontotemporal dementia. Rev Neurosci 2008; 9: 532–54410.1038/nrn242018568014
  52. 52. Obulesu M, Rao DM. DNA damage and impairment of DNA repair in Alzheimer’s disease. Int J Neurosci 2010; 120: 397–403.10.3109/0020745090341113320504209
  53. 53. Hou Y, Song H, Croteau DL, Akbari M, Bohr VA. Genome instability in Alzheimer disease. Mech Ageing Dev 2017; 161: 83–94.10.1016/j.mad.2016.04.005519591827105872
  54. 54. Malpass K. Alzheimer disease: DNA damage provides novel and powerful biomarkers of Alzheimer disease. Nat Rev Neurol. 2012; 8: 178.10.1038/nrneurol.2012.3522391481
  55. 55. Inoue K, Rispoli J, Kaphzan H, Klann E, Chen EI, Kim J et al. Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway. Mol Neurodegen. 2012; 7: 48.10.1186/1750-1326-7-48354459622998728
  56. 56. Bateman RJ, Munsell LY, Morris JC, Swarm R, Yarasheski KE, Holtzman DM. Human amyloid-beta synthesis and clearance rates as measured in cerebrospinal fluid in vivo. Nat Med. 2006; 12: 856–861.10.1038/nm1438298309016799555
  57. 57. Pennisi M, Crupi R, Di Paola R, et al. Inflammasomes, hormesis, and antioxidants in neuroinflammation: Role of NRLP3 in Alzheimer disease. J Neurosci Res. 2017; 95(7): 1360-1372.10.1002/jnr.2398627862176
  58. 58. Singhal G, Jaehne EJ, Corrigan F, Toben C, Baune BT. Inflammasomes in neuroinflammation and changes in brain function: a focused review. Front Neurosci. 2014; 8:315.10.3389/fnins.2014.00315418803025339862
  59. 59. Halle A, Hornung V, Petzold GC, et al. The NALP3 inflammasome is involved in the innate immune response to amyloid-beta. Nat Immunol. 2008; 9(8): 857-865.10.1038/ni.1636310147818604209
  60. 60. Heneka MT, Kummer MP, Stutz A, et al. NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice. Nature. 2013; 493(7434): 674-678.10.1038/nature11729381280923254930
  61. 61. Rubartelli A. DAMP-mediated activation of NLRP3- inflammasome in brain sterile inflammation: the fine line between healing and neurodegeneration. Front Immunol. 2014; 5:99.10.3389/fimmu.2014.00099395612224672523
  62. 62. Wu GF, Alvarez E. The immunopathophysiology of multiple sclerosis. Neurol Clin. 2011; 29(2): 257-278.10.1016/j.ncl.2010.12.009
  63. 63. Wang K, Song F, Fernandez-Escobar A, Luo G, Wang JH, Sun Y. The Properties of Cytokines in Multiple Sclerosis: Pros and Cons. Am J Med Sci. 2018; 356(6): 552-560.10.1016/j.amjms.2018.08.018
  64. 64. Lucchinetti C, Brück W, Parisi J, Scheithauer B, Rodriguez M, Lassmann H. Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination. Ann Neurol. 2000; 47(6): 707-717.10.1002/1531-8249(200006)47:6<;707::AID-ANA3>3.0.CO;2-Q
  65. 65. Steinman L, Zamvil SS. How to successfully apply animal studies in experimental allergic encephalomyelitis to research on multiple sclerosis. Ann Neurol. 2006; 60(1): 12-21.10.1002/ana.20913
  66. 66. Kuchroo VK, Anderson AC, Waldner H, Munder M, Bettelli E, Nicholson LB. T cell response in experimental autoimmune encephalomyelitis (EAE): role of self and cross-reactive antigens in shaping, tuning, and regulating the autopathogenic T cell repertoire. Annu Rev Immunol. 2002; 20:101-123.10.1146/annurev.immunol.20.081701.141316
  67. 67. Kouchaki E, Tamtaji OR, Dadgostar E, Karami M, Nikoueinejad H, Akbari H. Correlation of Serum Levels of IL-33, IL-37, Soluble Form of Vascular Endothelial Growth Factor Receptor 2 (VEGFR2), and Circulatory Frequency of VEGFR2-expressing Cells with Multiple Sclerosis Severity. Iran J Allergy Asthma Immunol. 2017; 16(4): 329-337
  68. 68. Zhang F, Tossberg JT, Spurlock CF, Yao SY, Aune TM, Sriram S. Expression of IL-33 and its epigenetic regulation in Multiple Sclerosis. Ann Clin Transl Neurol. 2014; 1(5): 307-318.10.1002/acn3.47
  69. 69. Alsahebfosoul F, Rahimmanesh I, Shajarian M, et al. Interleukin- 33 plasma levels in patients with relapsing-remitting multiple sclerosis [published correction appears in Biomol Concepts. 2017;]. Biomol Concepts. 2017; 8(1): 55-60.10.1515/bmc-2016-0026
  70. 70. Christophi GP, Gruber RC, Panos M, Christophi RL, Jubelt B, Massa PT. Interleukin-33 upregulation in peripheral leukocytes and CNS of multiple sclerosis patients. Clin Immunol 2012; 142: 308–19.10.1016/j.clim.2011.11.007
  71. 71. Kanda T. Interleukin-33/suppression of tumorigenicity 2 system: can it be a future therapeutic target for neuroimmunological disorders? Clin Exp Neuroimmunol. 2013; 4: 255–6
  72. 72. Wang S, Ding L, Liu S-S, Wang C, Leng R-X, Chen GM, et al. IL-33: a potential therapeutic target in autoimmune diseases. J Investig Med. 2012; 60: 1151–6.10.2310/JIM.0b013e31826d8fcb
  73. 73. Li M, Li Y, Liu X, Gao X, Wang Y. IL-33 blockade suppresses the development of experimental autoimmune encephalomyelitis in C57BL/6 mice. J Neuroimmunol. 2012; 247(1-2): 25-31.10.1016/j.jneuroim.2012.03.016
  74. 74. Chen H, Sun Y, Lai L, et al. Interleukin-33 is released in spinal cord and suppresses experimental autoimmune encephalomyelitis in mice. Neuroscience. 2015; 308:157-168.10.1016/j.neuroscience.2015.09.01926363151
  75. 75. Xiao Y, Lai L, Chen H, et al. Interleukin-33 deficiency exacerbated experimental autoimmune encephalomyelitis with an influence on immune cells and glia cells. Mol Immunol. 2018; 101:550-563.10.1016/j.molimm.2018.08.02630173119
  76. 76. Barbour M, Wood R, Hridi SU, et al. The therapeutic effect of anti-CD52 treatment in murine experimental autoimmune encephalomyelitis is associated with altered IL-33 and ST2 expression levels. J Neuroimmunol. 2018; 318:87-96.10.1016/j.jneuroim.2018.02.01229526407
  77. 77. Zhao X, Zhang X, Lv Y, et al. Matrine downregulates IL-33/ST2 expression in the central nervous system of rats with experimental autoimmune encephalomyelitis. Immunol Lett. 2016; 178:97-104.10.1016/j.imlet.2016.08.00727562326
  78. 78. Jafarzadeh A, Mohammadi-Kordkhayli M, Ahangar- Parvin R, et al. Ginger extracts influence the expression of IL-27 and IL-33 in the central nervous system in experimental autoimmune encephalomyelitis and ameliorates the clinical symptoms of disease. J Neuroimmunol. 2014; 276(1-2):80-88.10.1016/j.jneuroim.2014.08.61425175065
  79. 79. Finlay CM, Stefanska AM, Walsh KP, et al. Helminth Products Protect against Autoimmunity via Innate Type 2 Cytokines IL-5 and IL-33, Which Promote Eosinophilia. J Immunol. 2016; 196(2):703-714.10.4049/jimmunol.150182026673140
  80. 80. Russi AE, Ebel ME, Yang Y, Brown MA. Male-specific IL-33 expression regulates sex-dimorphic EAE susceptibility. Proc Natl Acad Sci U S A. 2018; 115(7): E1520-E1529.10.1073/pnas.1710401115581614029378942
DOI: https://doi.org/10.2478/sjecr-2020-0038 | Journal eISSN: 2956-2090 | Journal ISSN: 2956-0454
Language: English
Submitted on: Aug 25, 2020
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Accepted on: Sep 10, 2020
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Published on: Dec 8, 2021
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2021 Jelena Dimitrijevic, Aleksandar Arsenijevic, Marija Milovanovic, Bojana Stojanovic, Dragana Arsenijevic, Jelena Milovanovic, Nebojsa Arsenijevic, published by University of Kragujevac, Faculty of Medical Sciences
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