Role of IL-33/ST2 Axis in Chronic Inflammatory Neurological Disorderss

Jelena Dimitrijevic; Aleksandar Arsenijevic; Marija Milovanovic; Bojana Stojanovic; Dragana Arsenijevic; Jelena Milovanovic; Nebojsa Arsenijevic

doi:10.2478/sjecr-2020-0038

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Role of IL-33/ST2 Axis in Chronic Inflammatory Neurological Disorderss

EABR. Experimental and Applied Biomedical Research

AHEAD OF PRINT

By: Jelena Dimitrijevic, Aleksandar Arsenijevic, Marija Milovanovic, Bojana Stojanovic, Dragana Arsenijevic, Jelena Milovanovic and Nebojsa Arsenijevic

Open Access

|Dec 2021

Abstract

Interleukin-33 (IL-33) is a member of IL-1 family of cytokines, produced constitutively by fibroblasts, endothelial cells, and epithelial cells. IL-33 can be released passively from cells during tissue damage and cell necrosis, suggesting that it may act as an alarmin. Function of IL-33 is mediated by its interaction with ST2 molecule that is expressed on many immune cells: Th2 lymphocytes, NK, NKT and mast cells, monocytes, dendritic cells and granulocytes. IL-33/ST2 pathway plays, often dual, roles in different physiological and inflammatory processes, mediating both, pathological immune responses and tissue repair. Expression of IL-33 in the central nervous system (CNS) is significantly enhanced during various pathological processes, indicating its important role in the pathogenesis of neurological inflammatory and degenerative diseases. In this review the biological features, expression of IL-33 and its ligand ST2 in CNS, and the role of IL- 33/ST2 pathway in development of Alzheimer’s disease and multiple sclerosis are discussed.

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Articles in this issue

DOI: https://doi.org/10.2478/sjecr-2020-0038 | Journal eISSN: 2956-2090 (formerly 2335-075X, 2956-0454) | Journal ISSN: 2956-0454 (formerly 1820-8665)

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Language: English

Submitted on: Aug 25, 2020

Accepted on: Sep 10, 2020

Published on: Dec 8, 2021

Published by: University of Kragujevac, Faculty of Medical Sciences

In partnership with: Paradigm Publishing Services

Keywords:

IL-33,

ST2,

Related subjects:

Clinical medicine, other

© 2021 Jelena Dimitrijevic, Aleksandar Arsenijevic, Marija Milovanovic, Bojana Stojanovic, Dragana Arsenijevic, Jelena Milovanovic, Nebojsa Arsenijevic, published by University of Kragujevac, Faculty of Medical Sciences
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