References
- 1. Lvov, D. et. al. (2016) Virological, epidemiological, clinic, and molecular genetic features of the influenza epidemic in 2015-2016: prevailing of the influenza A(H1N1)09 pdm virus in Russia and countries of the Northern hemisphere. Voprosy Virusologii, 61(4), 159-166
- 2. Goncharova, O. V. (2016). Phytotherapy in treatment and rehabilitation of children recovering from acute respiratory viral infections. Medical Council, 1(1), 58–62.
- 3. Ulasevich, A., Jacobs, S., Mbangdadji, D., van Over, M., & Steffens, L. (2017). Understanding Flu Vaccination in a Competitive Context. Social Marketing Quarterly, 23(4), 320–334.10.1177/1524500417718141
- 4. Trieu, M. C., Zhou, F., Lartey, S. L., Sridhar, S., Mjaa-land, S., & Cox, R. J. (2018) Augmented CD4(+) T-cell and humoral responses after repeated annual influenza vaccination with the same vaccine component A/H1N1pdm09 over 5 years. NPJ. Vaccines. 3, 37.
- 5. Blakely, S. A. R. (n.d.). Research Approaches to Special Preclinical Safety and Toxicological Evaluations. Nutraceuticals, 45–53.
- 6. Mishra, S., & Kumar, H. (2017). Balancing anti-viral innate immunity and immune homeostasis. Cellular and Molecular Immunology. doi:10.1038/cmi.2017.9810.1038/cmi.2017.98
- 7. Mänz, B., Dornfeld, D., Götz, V., Zell, R., Zimmer-mann, P., Haller, O. Schwemmle, M. (2013). Pandemic Influenza A Viruses Escape from Restriction by Human MxA through Adaptive Mutations in the Nucleo-protein. PLoS Pathogens, 9(3), e1003279. doi:10.1371/journal.ppat.1003279
- 8. Hamming, O. J., Terczyńska-Dyla, E., Vieyres, G., Dijkman, R., Jørgensen, S. E., Akhtar, H. Hartmann, R. (2013). Interferon lambda 4 signals via the IFNλ receptor to regulate antiviral activity against HCV and coronaviruses. The EMBO Journal, 32(23), 3055–3065. doi:10.1038/emboj.2013.232
- 9. Ershov F.I. Narovlyansky A.N. (2015) Use of interferon inducers in viral infections. Voprosi virusologii; 60 (2): 54-10. PMID:26182650;
- 10. Galegov, G. A., et al. (2002) The effect of Kagocel on herpes virus reproduction. Voprosy virusologii 47(4) 42-44.12271726
- 11. Sologub, T. V., & Tsvetkov, V. V. (2017). Kagocel in the therapy of influenza and acute respiratory viral infections: Data analysis and systematization from the results of preclinical and clinical trials. Terapevticheskii Arkhiv, 89(8), 113.
- 12. Myat, T. S., & Tetsuka, M. (2016). Gossypol inhibits LH-induced steroidogenesis in bovine theca cells. Animal Science Journal, 88(1), 63–71.
- 13. Warnsmann, V., Meyer, N., Hamann, A., Kögel, D., & Osiewacz, H. D. (2017). A novel role of the mitochondrial permeability transition pore in (−)-gossypol-induced mitochondrial dysfunction. Mechanisms of Ageing and Development. doi:10.1016/j.mad.2017.06.00410.1016/j.mad.2017.06.004
- 14. Keshmiri-Neghab, H., & Goliaei, B. (2013). Therapeutic potential of gossypol: An overview. Pharmaceutical Biology, 52(1), 124–128. doi: 10.3109/13880209.2013.83277610.3109/13880209.2013.832776
- 15. Yang, Z.-J., Ye, W.-S., Cui, G.-H., Guo, Y., & Xue, S.-P. (2004). Combined administration of low-dose gossypol acetic acid with desogestrel/mini-dose ethinylestradiol/testosterone undecanoate as an oral contraceptive for men. Contraception, 70(3), 203–211.10.1016/j.contraception.2004.02.019
- 16. Schwartze, E. W. (1926). Gossypol and cottonseed meal poisoning. Journal of Oil & Fat Industries, 3(5), 173–178.
- 17. Lu, Y., Li, J., Dong, C.-E., Huang, J., Zhou, H.-B., & Wang, W. (2017). Recent advances in gossypol derivatives and analogs: a chemistry and biology view. Future Medicinal Chemistry, 9(11), 1243–1275.
- 18. Xu, L., Yang, D., Wang, S., Tang, W., Liu, M., Chen, J., Lippman, M. E. (2004). 643 Radiosensitization of human prostate cancer by natural polyphenol inhibitor of Bcl-2/XL, (−)-gossypol, results in tumor regression. European Journal of Cancer Supplements, 2(8), 194. doi:10.1016/s1359-6349(04)80651-710.1016/S1359-6349(04)80651-7
- 19. Borovskaya, T. G. (2017). Safety of the Russian antiviral drug Kagocel. Terapevticheskii Arkhiv, 89(11), 93.
- 20. Ye W et al. (2010). Induction of apoptosis by (-)-gossypol-enriched cottonseed oil in human breast cancer cells. International Journal of Molecular Medicine, 26(1), 113-119.
- 21. Yang, J., Li, L.-L., Li, J.-R., Yang, J.-X., Zhang, F., Chen, G., Wu, S.-W. (2018). Synthesis and biological evaluation of water-soluble derivatives of chiral gossypol as HIV fusion inhibitors targeting gp41. Bioorganic & Medicinal Chemistry Letters, 28(1), 49–52. doi:10.1016/j.bmcl.2017.08.04910.1016/j.bmcl.2017.08.049
- 22. Tilyabaev, K. Z., Kamaev, F. G., Vypova, N. L., Yuldashev, A. M., Ibragimov, B. T., & Talipov, S. A. (2010). Synthesis, structures, and acute toxicity of gossypol nonsymmetrical aldehyde derivatives. Russian Journal of Bioorganic Chemistry, 36(3), 390–395.10.1134/S1068162010030167
- 23. Aoyama, K. (2008). Determination of Gossypol in Feeds by HPLC. Journal of the Food Hygienic Society of Japan (Shokuhin Eiseigaku Zasshi), 49(4), 303–307.10.3358/shokueishi.49.303
- 24. Habas, K., Brinkworth, M. H., & Anderson, D. (2017). In vitroresponses to knownin vivogenotoxic agents in mouse germ cells. Environmental and Molecular Mutagenesis, 58(2), 99–107.10.1002/em.22075
- 25. Gossypol as undesirable substance in animal feed - Scientific Opinion of the Panel on Contaminants in the Food Chain. EFSA Journal, 7(1), 908.
- 26. Zhang, W., Huang, C., Xie, W., & Shen, L. (2014). Determination of gossypol in edible vegetable oil with high performance liquid chromatography-tandem mass spec-trometry. Chinese Journal of Chromatography, 32(6), 582.
- 27. Borovskaya, T. G., Poluektova, M. E., Vychuzhanina, A. V., Mashanova, V. A., & Shchemerova, Y. A. (2017). Experimental Assessment of the Effect of Kagocel on Reproductive Function in Pubertal Male Rats. Bulletin of Experimental Biology and Medicine, 163(2), 214–217.
- 28. Vinokurov, A. A. Hodgkin’s lymphoma and male fertility disorders. Klin. Onkogematol. 2013;6(3):258-273.
- 29. Durnev, A. D., Smol’nikova, N. M., Skosureva, A. M., Nemova, E. P., Solomina, A. S., Shrede O. V., Gus’kova, T. A., Verstakova, O. L., & Syubaev, R.D. Methodical recommendations for preclinical study of reproductive toxicity of new drugs. Manual for Preclinical Studies of New Pharmacological Substances. Mironov AN, Bunatyan ND. Moscow, 2013. Part I. P. 80-93.
- 30. Rybalkin, S. P., Konovalova, E. V., Guskova, T. A., & Savinova, T. B. Experimental evaluation of the effect of Kagocel on generative function in animals. Toksikol. Vestnik. 2013. 2: 33-38.
- 31. Harlamov, F. S., Kladova, O. V., Uchaykin, V. F., Cheshik, S. G., Vartanyan, R. V., & Yablonskaya, K. P. (2015). Metapneumovirus and bokavirus respiratory infections in the structure of sars in children. Children infections, 14(2), 5–11.
- 32. De Peyster, A., & Wang, Y. Y. (1993) Genetic toxicity studies of gossypol. Mutat. Res. 297(3), 293-312.