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The Role of Probiotics, Prebiotics, and Synbiotics for Reducing Chemotherapy-Induced Gastrointestinal Toxicity: A Systematic Review and Meta-Analysis Cover

The Role of Probiotics, Prebiotics, and Synbiotics for Reducing Chemotherapy-Induced Gastrointestinal Toxicity: A Systematic Review and Meta-Analysis

Romanian Journal of Internal Medicine
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By: ,  ,  ,  ,  ,   and    
Open Access
|May 2026
Figures & tables

Figures & Tables

Figure 1.

PRISMA flow diagram of study selection.

Figure 2.

Risk of bias assessment across included studies.

Figure 3.

Forest plots of probiotic supplementation effects in chemotherapy-treated cancer patients: (A) diarrhea; (B) nausea and vomiting.

Figure 4.

Forest plots of sub-group meta-analysis of probiotic supplementation effects in chemotherapy-treated cancer patients based on its strain.

Figure 5.

Forest plots of prebiotic supplementation effects in chemotherapy-treated cancer patients: (A) diarrhea; (B) nausea and vomiting; (C) constipation.

Figure 6.

Forest plots of synbiotic supplementation effects in chemotherapy-treated cancer patients: (A) diarrhea; (B) nausea and vomiting.
DOI: https://doi.org/10.2478/rjim-2026-0011 | Journal eISSN: 2501-062X | Journal ISSN: 1220-4749
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Language: English
Submitted on: Feb 22, 2026
Published on: May 25, 2026
Published by: N.G. Lupu Internal Medicine Foundation
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year
Keywords:
probiotics,
prebiotics,
synbiotics,
chemotherapy,
gastrointestinal toxicity
Related subjects:
Medicine,
Clinical medicine,
Internal medicine,
Internal medicine, other,
Cardiology,
Gastroenterology,
Rheumatology

© 2026 Ermin Rachmawati, Roihatul Mutiah, Syafiq Maulana, Fildzah Ghaisani Alifah, Qanita Adzkia Novindra, Alvi Milliana, Imam Taufik, published by N.G. Lupu Internal Medicine Foundation
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

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