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Monosodium urate crystals exposure is associated with limited transcriptional changes in primary human PBMCs Cover

Monosodium urate crystals exposure is associated with limited transcriptional changes in primary human PBMCs

Open Access
|Sep 2025

Authors

Valentin Nica

Department of Medical Genetics and Department of Translational Immunology, Medfuture Institute for Biomedical Research, UMF “Iuliu Hatieganu”, Cluj-Napoca, Romania

Medeea Badii

Department of Medical Genetics and Department of Translational Immunology, Medfuture Institute for Biomedical Research, UMF “Iuliu Hatieganu”, Cluj-Napoca, Romania
Department of Internal Medicine and Research Institute for Medical Innovations, Radboud University Medical Center, Nijmegen, the Netherlands

Orsolya Gaal

Department of Medical Genetics and Department of Translational Immunology, Medfuture Institute for Biomedical Research, UMF “Iuliu Hatieganu”, Cluj-Napoca, Romania
Department of Internal Medicine and Research Institute for Medical Innovations, Radboud University Medical Center, Nijmegen, the Netherlands

Georgiana Cabău

Department of Medical Genetics and Department of Translational Immunology, Medfuture Institute for Biomedical Research, UMF “Iuliu Hatieganu”, Cluj-Napoca, Romania

Maartje Cleophas

Department of Internal Medicine and Research Institute for Medical Innovations, Radboud University Medical Center, Nijmegen, the Netherlands

Akshayata Naidu

Department of Computational Biology for Individualised Medicine, Centre for Individualised Infection Medicine (CiiM), TWINCORE, a joint venture between the Helmholtz-Centre for Infection Research (HZI) and Hannover Medical School (MHH), Hannover, Germany, Hannover, Germany

Ioana Hotea

Department of Rheumatology, VieCuri Medical Center, Venlo, Netherlands

Tim L. Jansen

Department of Rheumatology, VieCuri Medical Center, Venlo, Netherlands

Cristina Pamfil

Department of Rheumatology, UMF “Iuliu Hatieganu”, Cluj-Napoca, Romania

Simona Rednic

Department of Rheumatology, UMF “Iuliu Hatieganu”, Cluj-Napoca, Romania

Radu A. Popp

Department of Medical Genetics and Department of Translational Immunology, Medfuture Institute for Biomedical Research, UMF “Iuliu Hatieganu”, Cluj-Napoca, Romania

Yang Li

Department of Medical Genetics and Department of Translational Immunology, Medfuture Institute for Biomedical Research, UMF “Iuliu Hatieganu”, Cluj-Napoca, Romania
Department of Computational Biology for Individualised Medicine, Centre for Individualised Infection Medicine (CiiM), TWINCORE, a joint venture between the Helmholtz-Centre for Infection Research (HZI) and Hannover Medical School (MHH), Hannover, Germany, Hannover, Germany

Tania O. Crișan

tania.crisan@umfcluj.ro

Department of Medical Genetics and Department of Translational Immunology, Medfuture Institute for Biomedical Research, UMF “Iuliu Hatieganu”, Cluj-Napoca, Romania
Department of Internal Medicine and Research Institute for Medical Innovations, Radboud University Medical Center, Nijmegen, the Netherlands

Leo A.B. Joosten

Department of Medical Genetics and Department of Translational Immunology, Medfuture Institute for Biomedical Research, UMF “Iuliu Hatieganu”, Cluj-Napoca, Romania
Department of Internal Medicine and Research Institute for Medical Innovations, Radboud University Medical Center, Nijmegen, the Netherlands
DOI: https://doi.org/10.2478/rjim-2025-0019 | Journal eISSN: 2501-062X | Journal ISSN: 1220-4749
Language: English
Page range: 300 - 309
Submitted on: Aug 25, 2025
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Published on: Sep 18, 2025
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2025 Valentin Nica, Medeea Badii, Orsolya Gaal, Georgiana Cabău, Maartje Cleophas, Akshayata Naidu, Ioana Hotea, , Tim L. Jansen, Cristina Pamfil, Simona Rednic, Radu A. Popp, Yang Li, Tania O. Crișan, Leo A.B. Joosten, published by N.G. Lupu Internal Medicine Foundation
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.