Figure 1
Timeline of diagnostic feature evolution
| Feature | 2023 | 2024 | 2025 |
|---|---|---|---|
| Asthma | − | + | + |
| Eosinophilia | + | + | + |
| ENT involvement | − | − | − |
| Pulmonary infiltrates | − | − | + |
| Neuropathy (mononeuritis multiplex) | + | + | + |
| Skin manifestations | − | − | − |
| Cardiac involvement | + | + | + |
| Gastrointestinal involvement | − | − | − |
| Renal involvement | − | − | − |
| ANCA positivity | − | − | − |
| Histopathology | − | − | − |
| Systemic symptoms | + | + | + |
Temporal evolution of the important laboratory parameters (2)
| Data | Proteinuria (mg/24h) | C3 (g/L) | C4 (g/L) | C-ANCA AB (UI/ml) | P-ANCA AB (UI/ml) |
|---|---|---|---|---|---|
| January–February 2023 | 126 | 1.01 | 0.11 | ||
| January 2024 | 80.4 | 01.08 | 0.2 | 2.36 | 1.73 |
| June–July 2025 | 103.51 | 1.52 | 0.07 | 0.45 | 0.28 |
Antibody levels relevant to vasculitis workup
| Antibodies | Value | Reference range for normal |
|---|---|---|
| Anti-dsDNA (IU/mL) | 13.52 | <200 |
| Anti-CCP (IU/mL) | 1.40 | 0–20 |
| Anti-Ro (Anti-SSA) (IU/mL) | 0.78 | 0–20 |
| Anti-Sm (Anti-SSB) (IU/mL) | 1.93 | 0–20 |
| Antinuclear AB(ANA) (IU/mL) | 9.04 | 0–20 |
| Anti-β2 Glycoprotein I IgG (SGU/mL) | 2.47 | 0–20 |
| Anti-cardiolipin IgG (GLP/mL) | 1.36 | 0–20 |
| Anti-cardiolipin IgM(MPL/mL) | 5.73 | 0–20 |
Serum protein electrophoresis in 2025
| Serum protein electrophoresis | Normal range | |
|---|---|---|
| Beta B1 | 6.20 | 4.70 – 7.20 % |
| Beta B2 | 6.90 | 3.20 – 6.50 % |
| Alfa 2 | 13.40 | 7.10 – 11.80 % |
| Alfa 1 | 6.10 | 2.90 – 4.90 % |
| Albumin | 49.00 | 55.80 – 66.10 % |
| Albumin-Globulin ratio | 0.96 | 1.1–2.5 |
| Gamma | 18.40 | 10.5–19.2 % |
Temporal evolution of the important laboratory parameters (1)
| Data | Eosinophiles (*1000/mcL) | CRP (mg/L) | ESR (mm/h) | Fibrinogen (mg/dl) | IgE (IU/ml) | NTproBNP (pg/mL) | hsTnT (pg/mL) | LDH (UI/L) |
|---|---|---|---|---|---|---|---|---|
| January 2023 | 15.36 | 38.5 | 32 | 482 | 1296 | 6174 | 1445 | 607 |
| February 2023 | 0.06 | 0.27 | 2 | 226 | 1967 | 50.24 | ||
| July 2023 | 0.24 | 0.99 | 4 | 762 | 18.96 | |||
| January 2024 | 1.64 | 0.7 | 2 | 349 | 219 | 539 | 10.02 | 206 |
| April 2024 | 1.24 | 1.05 | 7 | 371 | 275 | 500 | ||
| June 2025 | 7.00 | 42.5 | 55 | 539 | 3782 | 509 | 15 | 502 |
| July 2025 | 0.03 | 1.63 | 7 | 336 | 966 | 366 | 232 |