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Capillaroscopic insights: exploring the connection between microvascular changes and pulmonary manifestations in systemic sclerosis Cover

Capillaroscopic insights: exploring the connection between microvascular changes and pulmonary manifestations in systemic sclerosis

Open Access
|Mar 2025

References

  1. DERK C.T., JIMENEZ S.A. Systemic sclerosis: current views of its pathogenesis. Autoimmun. Rev. 2003; 2:181–191
  2. HERRICK A.L., MATUCCI CERINIC M. The emerging problem of oxidative stress and the role of antioxidants in systemic sclerosis. Clin. Exp. Rheumatol. 2001; 19:4–8
  3. ASSASSI S., MAYES M.D., ARNETT F.C., GOURH P., AGARWAL S.K., MCNEARNEY T.A., et al. Systemic sclerosis and lupus: Points in an interferon‐mediated continuum. Arthritis Rheum. 2010; 62:589–598
  4. DOMSIC R.T. Scleroderma. Curr. Opin. Rheumatol. 2014; 26:646–652
  5. SMITH V., DECUMAN S., SULLI A., BONROY C., PIETTTE Y., DESCHEPPER E., et al. Do worsening scleroderma capillaroscopic patterns predict future severe organ involvement? a pilot study. Ann. Rheum. Dis. 2012; 71:1636–1639
  6. ELSAYED A.M., ELHEFNY A.M., ABOGABAL M.M., MOBASHER S.A., ABDELZAHER A., ALHASSANEIN K.F., et al. Progressive systemic sclerosis in Egyptian patients: Clinical characteristics and nail fold capillaroscopy. Egypt. Rheumatol. 2019; 41:47–51
  7. MEIJS J., SCHOUFFOER A.A., AJMONE MARSAN N., KROFT L.J.M., STIJNEN T., NINABER M.K., et al. Therapeutic and diagnostic outcomes of a standardised, comprehensive care pathway for patients with systemic sclerosis. RMD Open 2016; 2:e000159
  8. PRESTON I.R., HILL N.S. Evaluation and management of pulmonary hypertension in systemic sclerosis. Curr. Opin. Rheumatol. 2003; 15:761–765
  9. BEHR J., VOGELMEIER C., BEINERT T., MEURER M., KROMBACH F., KÖNIG G., et al. Bronchoalveolar lavage for evaluation and management of scleroderma disease of the lung. Am. J. Respir. Crit. Care Med. 1996; 154:400–406
  10. TYNDALL A.J., BANNERT B., VONK M., AIRO P., COZZI F., CARREIRA P.E., et al. Causes and risk factors for death in systemic sclerosis: a study from the EULAR Scleroderma Trials and Research (EUSTAR) database. Ann. Rheum. Dis. 2010; 69:1809–1815
  11. MUKERJEE D. Prevalence and outcome in systemic sclerosis associated pulmonary arterial hypertension: application of a registry approach. Ann. Rheum. Dis. 2003; 62:1088–1093
  12. DEMEROUTI E., TSANGARIS I., DIMITROULAS T., GIANNAKOULAS G., KATSIMPRI P., MITROUSKA I., et al. Pulmonary Arterial Hypertension in Connective Tissue Disorders: The emerging role of screening and early diagnosis. A position paper for Greek Rheumatologists. Mediterr. J. Rheumatol. 2019; 30:90–93
  13. INGEGNOLI F., ARDOINO I., BORACCHI P., CUTOLO M., AIRÒ P., ANANIEVA L.P., et al. Nailfold capillaroscopy in systemic sclerosis: Data from the EULAR scleroderma trials and research (EUSTAR) database. Microvasc. Res. 2013; 89:122–128
  14. HERRICK A.L., CUTOLO M. Clinical implications from capillaroscopic analysis in patients with Raynaud’s phenomenon and systemic sclerosis. Arthritis Rheum. 2010; 62:2595–2604
  15. VAN DEN HOOGEN F., KHANNA D., FRANSEN J., JOHNSON S.R., BARON M., TYNDALL A., et al. 2013 classification criteria for systemic sclerosis: an American college of rheumatology/European league against rheumatism collaborative initiative. Ann. Rheum. Dis. 2013; 72:1747–1755
  16. VASILE M., AVOUAC J., SCIARRA I., STEFANANTONI K., IANNACE N., CRAVOTTO E., et al. From VEDOSS to established systemic sclerosis diagnosis according to ACR/EULAR 2013 classification criteria: a French-Italian capillaroscopic survey. Clin. Exp. Rheumatol. 2018; 36 Suppl 1:82–87
  17. CUTOLO M., MELSENS K., WIJNANT S., INGEGNOLI F., THEVISSEN K., DE KEYSER F., et al. Nailfold capillaroscopy in systemic lupus erythematosus: A systematic review and critical appraisal. Autoimmun. Rev. 2018; 17:344–352
  18. MEDSGER T.A., BOMBARDIERI S., CZIRJAK L., SCORZA R., DELLA ROSSA A., BENCIVELLI W. Assessment of disease severity and prognosis. Clin. Exp. Rheumatol. 2003; 21:S42-6
  19. INSTITUTE OF MEDICINE OF THE NATIONAL ACADEMIES. Cardiovascular Disability: Updating the Social Security Listings, The National Academies Press, Washington, DC, 2010
  20. PATTANAIK D., BROWN M., POSTLETHWAITE B.C., POSTLETHWAITE A.E. Pathogenesis of Systemic Sclerosis. Front. Immunol. 2015; 6:272
  21. CUTOLO M., SULLI A., SMITH V. How to perform and interpret capillaroscopy. Best Pract. Res. Clin. Rheumatol. 2013; 27:237–248
  22. SULLI A., PIZZORNI C., SMITH V., ZAMPOGNA G., RAVERA F., CUTOLO M. Timing of transition between capillaroscopic patterns in systemic sclerosis. Arthritis Rheum. 2012; 64:821–825
  23. MOORE D.F., STEEN V.D. Overall mortality. J. Scleroderma Relat. Disord. 2021; 6:3–10
  24. WALKER U.A., TYNDALL A., CZIRJAK L., DENTON C., FARGE-BANCEL D., KOWAL-BIELECKA O., et al. Clinical risk assessment of organ manifestations in systemic sclerosis: a report from the EULAR Scleroderma Trials And Research group database. Ann. Rheum. Dis. 2007; 66:754–763
  25. RAHAGHI F.F., HSU V.M., KANER R.J., MAYES M.D., ROSAS I.O., SAGGAR R., et al. Expert consensus on the management of systemic sclerosis-associated interstitial lung disease. Respir. Res. 2023; 24:6
  26. COGHLAN J.G., DENTON C.P., GRÜNIG E., BONDERMAN D., DISTLER O., KHANNA D., et al. Evidence-based detection of pulmonary arterial hypertension in systemic sclerosis: the DETECT study. Ann. Rheum. Dis. 2014; 73:1340–1349
  27. VOLKMANN E.R., FISCHER A. Update on morbidity and mortality in systemic sclerosis–related interstitial lung disease. J. Scleroderma Relat. Disord. 2021; 6:11–20
  28. GUALTIEROTTI R., INGEGNOLI F., GRIFFINI S., GROVETTI E., BORGHI M.O., BUCCIARELLI P., et al. Detection of early endothelial damage in patients with Raynaud’s phenomenon. Microvasc. Res. 2017; 113:22–28
  29. CESTELLI V., MANFREDI A., SEBASTIANI M., PRAINO E., CANNARILE F., GIUGGIOLI D., et al. Effect of treatment with iloprost with or without bosentan on nailfold videocapillaroscopic alterations in patients with systemic sclerosis. Mod. Rheumatol. 2017; 27:110–114
DOI: https://doi.org/10.2478/rjim-2024-0030 | Journal eISSN: 2501-062X | Journal ISSN: 1220-4749
Language: English
Page range: 39 - 48
Submitted on: Jun 21, 2024
Published on: Mar 31, 2025
Published by: N.G. Lupu Internal Medicine Foundation
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2025 Camelia Palici, Ananu Florentin Vreju, Cristina Elena Biţă, Ștefan Cristian Dinescu, Alesandra Florescu, Anca Emanuela Muşetescu, Andreea Lili Barbulescu, Paulina Lucia Ciurea, published by N.G. Lupu Internal Medicine Foundation
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.