The Effect of Oral Acetaminophen on Open Arterial Duct Closure in Premature Infants Less Than 32 Weeks

Noori, Noor Mohammad; Teimouri, Alireza; Dehvari, Abdollah; Bagheie, Somayeh; Ansari, Hossein

The Effect of Oral Acetaminophen on Open Arterial Duct Closure in Premature Infants Less Than 32 Weeks

Romanian Journal of Cardiology

Volume 33 (2023): Issue 2 (June 2023)

By:

Noor Mohammad Noori, Alireza Teimouri, Abdollah Dehvari, Somayeh Bagheie and Hossein Ansari

Open Access

|Jun 2023

Figures & Tables

The distribution of PDA closure in groups of neonates with and without acetaminophen intervention

Comparing some variables in preterm infants based on treatment

Variables	Treatment	Mean	SD	Mean Rank	MWU	P-value
Weight (gr)	No	1249.79	205.44	69.83	2403.00	0.844
Weight (gr)	Yes	1252.86	193.92	71.17	2403.00	0.844
Gestational Age (week)	No	30.03	1.55	69.27	2364.00	0.714
Gestational Age (week)	Yes	30.11	1.53	71.73	2364.00	0.714
Apgar in the first minute	No	7.40	0.75	71.06	2411.00	0.86
Apgar in the first minute	Yes	7.37	0.78	69.94	2411.00	0.86
Apgar in the fifth minute	No	8.6	0.67	70.54	2447.50	0.991
Apgar in the fifth minute	Yes	8.61	0.62	70.46	2447.50	0.991
LA/Ao	No	1.58	0.09	72.15	2334.50	0.627
LA/Ao	Yes	1.57	0.09	68.85	2334.50	0.627
PDA size before treatment	No	2.80	0.04	66.53	2172.00	0.247
PDA size before treatment	Yes	2.81	0.05	74.47	2172.00	0.247
PDA size after treatment	No	0.67	1.20	76.56	2025.50	0.004
PDA size after treatment	Yes	0.16	0.67	64.44	2025.50	0.004

Logistic regression analysis on affective variables on PDA status after treatment

	Regular Odds ratio					Adjusted Odds ratio
Variables (Reference group)	β	Wald	Sig.	OR	β	Wald	Sig.	OR
Sex (male)	0.090	0.036	0.849	1.094	-0.391	0.465	0.495	0.677
Weight	0.002	2.556	0.11	1.002	0.001	0.616	0.432	1.001
Gestational Age	0.376	6.078	0.014	1.457	0.371	2.925	0.087	1.449
Apgar at the first minute	0.503	2.463	0.117	1.654	0.966	3.134	0.077	2.626
Apgar at the fifth minute	0.239	0.417	0.518	1.27	-0.803	1.753	0.185	0.448
Parity 2 (parity 1)	0.049	0.007	0.931	1.05	-0.542	0.664	0.415	0.582
Parity 3 or more (parity 1)	0.548	0.884	0.347	1.73	0.459	0.453	0.501	1.582
LA/Ao	-1.893	0.474	0.491	0.151	-3.558	1.279	0.258	0.028
Treatment (No)	1.666	8.098	0.004	5.292	1.855	8.462	0.004	6.394

comparison between preterm neonates with PDA treatment with oral acetaminophen

Variables	PDA closure	Mean	SD	Mean Rank	MWU	P-value
Weight	Yes	1259.85	194.99	36.29	80.00	0.201
Weight	No	1137.5	149.3	22.50	80.00	0.201
Gestational Age	Yes	30.18	1.53	36.52	65.00	0.093
Gestational Age	No	29.00	1.15	18.75	65.00	0.093
Apgar at the first minute	Yes	7.42	0.77	36.76	49.00	0.033
Apgar at the first minute	No	6.50	0.58	14.75	49.00	0.033
Apgar at the fifth minute	Yes	8.65	0.62	36.68	54.00	0.047
Apgar at the fifth minute	No	8.00	0.01	16.00	54.00	0.047
LA/Ao	Yes	1.57	0.09	34.95	96.00	0.383
LA/Ao	No	1.61	0.07	44.50	96.00	0.383
PDA size before treatment	Yes	2.80	0.05	34.17	44.5.00	0.023
PDA size before treatment	No	2.86	0.02	57.38	44.5.00	0.023

Normality test for quantities variables

Variables	Mean	SD	K.S	P-value
Weight	1251.32	199.05	0.132	<0.001
Age	30.07	1.53	0.213	<0.001
Apgar in the first minute	7.39	0.76	0.25	<0.001
Apgar in the fifth minute	8.61	0.64	0.308	<0.001
LA/Ao	1.58	0.09	0.116	<0.001
PDA size before treatment	2.80	0.05	0.086	0.013
PDA size after treatment	0.42	1.00	0.512	<0.001

DOI: https://doi.org/10.2478/rjc-2023-0007 | Journal eISSN: 2734-6382 | Journal ISSN: 1220-658X

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Language: English

Page range: 54 - 59

Published on: Jun 30, 2023

Published by: Romanian Society of Cardiology

In partnership with: Paradigm Publishing Services

Publication frequency: 4 times per year

Keywords:

Related subjects:

Pediatrics and juvenile medicine,

Paediatric cardiology,

Surgery,

Cardiac surgery

© 2023 Noor Mohammad Noori, Alireza Teimouri, Abdollah Dehvari, Somayeh Bagheie, Hossein Ansari, published by Romanian Society of Cardiology
This work is licensed under the Creative Commons Attribution 4.0 License.

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The Effect of Oral Acetaminophen on Open Arterial Duct Closure in Premature Infants Less Than 32 Weeks

Figures & Tables

Figure 1

Comparing some variables in preterm infants based on treatment

Logistic regression analysis on affective variables on PDA status after treatment

comparison between preterm neonates with PDA treatment with oral acetaminophen

Normality test for quantities variables

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