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Human papillomavirus-related oropharyngeal squamous cell carcinoma exhibits enhanced radiosensitivity despite limited activation of cytosolic DNA sensing pathways and innate immune responses Cover

Human papillomavirus-related oropharyngeal squamous cell carcinoma exhibits enhanced radiosensitivity despite limited activation of cytosolic DNA sensing pathways and innate immune responses

Radiology and Oncology
Volume 59 (2025): Issue 4 (December 2025)
By: Kristina Levpuscek,  Tanja Jesenko,  Tilen Komel,  Simona Kranjc Brezar,  Gregor Sersa,  Maja Cemazar and  Primoz Strojan  
Open Access
|Dec 2025

Authors

Kristina Levpuscek

Department of Experimental Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia
Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia

Tanja Jesenko

Department of Experimental Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia
Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia

Tilen Komel

Department of Experimental Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia
Faculty of Mathematics, Natural Sciences and Information Technologies, University of Primorska, Koper, Slovenia

Simona Kranjc Brezar

Department of Experimental Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia
Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia

Gregor Sersa

Department of Experimental Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia
Faculty of Health Sciences, University of Ljubljana, Ljubljana, Slovenia

Maja Cemazar

Department of Experimental Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia
Faculty of Health Sciences, University of Primorska, Koper, Slovenia

Primoz Strojan

pstrojan@onko-i.si

Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
Department of Radiation Oncology, Institute of Oncology, Ljubljana, Slovenia
DOI: https://doi.org/10.2478/raon-2025-0057 | Journal eISSN: 1581-3207 | Journal ISSN: 1318-2099
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Language: English
Page range: 566 - 578
Submitted on: Aug 27, 2025
Accepted on: Sep 5, 2025
Published on: Dec 16, 2025
Published by: Association of Radiology and Oncology
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year
Keywords:
cytosolic DNA sensing pathways,
innate immune response,
human papillomavirus type 16,
pharyngeal squamous cell carcinoma,
radiation responseIntroduction
Related subjects:
Medicine,
Clinical medicine,
Internal medicine,
Haematology, oncology,
Radiology

© 2025 Kristina Levpuscek, Tanja Jesenko, Tilen Komel, Simona Kranjc Brezar, Gregor Sersa, Maja Cemazar, Primoz Strojan, published by Association of Radiology and Oncology
This work is licensed under the Creative Commons Attribution 4.0 License.

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