Have a personal or library account? Click to login
Investigation of GSTP1 and PTEN gene polymorphisms and their association with susceptibility to colorectal cancer Cover

Investigation of GSTP1 and PTEN gene polymorphisms and their association with susceptibility to colorectal cancer

Open Access
|Jan 2025

References

  1. Xi Y, Xu P. Global colorectal cancer burden in 2020 and projections to 2040. Transl Oncol 2021; 14: 101174. doi: 10.1016/j.tranon.2021.101174
  2. Huang P, Feng Z, Shu X, Wu A, Wang Z, Hu T, et al. A bibliometric and visual analysis of publications on artificial intelligence in colorectal cancer (20022022). Front Oncol 2023; 13: 1077539. doi: 10.3389/fonc.2023.1077539
  3. Bizuayehu HM, Dadi AF, Ahmed KY, Tegegne TK, Hassen TA, Kibret GD, et al. Burden of 30 cancers among men: Global statistics in 2022 and projections for 2050 using population-based estimates. Cancer 2024; 130: 3708-23. doi: 10.1002/cncr.35458
  4. Wani HA, Majid S, Bhat AA, Amin S, Farooq R, Bhat SA, et al. Impact of cat-echol-O-methyltransferase gene variants on methylation status of P16 and MGMT genes and their downregulation in colorectal cancer. Eur J Cancer Prev 2019; 28: 68-75. doi: 10.1097/CEJ.0000000000000485
  5. Morgan E, Arnold M, Gini A, Lorenzoni V, Cabasag CJ, Laversanne M, et al. Global burden of colorectal cancer in 2020 and 2040: incidence and mortality estimates from GLOBOCAN. Gut 2023; 72: 338-44. doi: 10.1136/gutjnl-2022-327736
  6. Hossain MS, Karuniawati H, Jairoun AA, Urbi Z, Ooi J, John A, et al. Colorectal cancer: a review of carcinogenesis, global epidemiology, current challenges, risk factors, preventive and treatment strategies. Cancers 2022; 14: 1732. doi: 10.3390/cancers14071732
  7. Parmar S, Easwaran H. Genetic and epigenetic dependencies in colorectal cancer development. Gastroenterol Rep 2022; 10: goac035. doi: 10.1093/gastro/goac035
  8. Li F, Qasim S, Li D, Dou QP. Updated review on green tea polyphenol epigallocatechin-3-gallate as a cancer epigenetic regulator. Semin Cancer Biol 2022; 83: 335-52. doi: 10.1016/j.semcancer.2020.11.018
  9. Franko A, Goricar K, Dodic Fikfak M, Kovac V, Dolzan V. The role of polymorphisms in glutathione-related genes in asbestos-related diseases. Radiol Oncol 2021; 55: 179-86. doi: 10.2478/raon-2021-0002
  10. Cui J, Li G, Yin J, Li L, Tan Y, Wei H, et al. GSTP1 and cancer: Expression, methylation, polymorphisms and signaling. Int J Oncol 2020; 56: 867-78. doi: 10.3892/ijo.2020.4979
  11. Gasic V, Zukic B, Stankovic B, Janic D, Dokmanovic L, Lazic J, et al. Pharmacogenomic markers of glucocorticoid response in the initial phase of remission induction therapy in childhood acute lymphoblastic leukemia. Radiol Oncol 2018; 52: 296-306. doi: 10.2478/raon-2018-0034
  12. Bartolini D, Torquato P, Piroddi M, Galli F. Targeting glutathione S-transferase P and its interactome with selenium compounds in cancer therapy. Biochim Biophys Acta Gen Subj 2019; 1863: 130-43. doi: 10.1016/j.bba-gen.2018.09.023
  13. Nissar S, Sameer AS, Rasool R, Chowdri N, Rashid F. Glutathione S transferases: biochemistry, polymorphism and role in colorectal carcinogenesis. J Carcinog Mutagen 2017; 8: 287. doi: 10.1007/s12253-019-00589-1
  14. Wang Q, Wang J, Xiang H, Ding P, Wu T, Ji G. The biochemical and clinical implications of phosphatase and tensin homolog deleted on chromosome ten in different cancers. Am J Cancer Res 2021; 11: 5833. PMID: 35018228
  15. Fusco N, Sajjadi E, Venetis K, Gaudioso G, Lopez G, Corti C, et al. M. PTEN alterations and their role in cancer management: are we making headway on precision medicine? Genes 2020; 11: 719. doi: 10.3390/genes11070719
  16. Vodusek AL, Goricar K, Gazic B, Dolzan V, Jazbec J. Antioxidant defence-related genetic variants are not associated with higher risk of secondary thyroid cancer after treatment of malignancy in childhood or adolescence. Radiol Oncol 2016; 50: 80-6. doi: 10.1515/raon-2015-0026
  17. Song DD, Zhang Q, Li JH, Hao RM, Ma Y, Wang PY, et al. Single nucleotide polymorphisms rs701848 and rs2735343 in PTEN increases cancer risks in an Asian population. Oncotarget 2017; 8: 96290. doi: 10.18632/onco-target.22019
  18. Lemoshow S, Hosmer Jr DW, Klar J, Lewang SK. Adecuacy of Simple size in healt studies. Chichester (England): John Wiley & Sons LTD; 1990.
  19. Welfare M, Monesola Adeokun A, Bassendine MF, Daly AK. Polymorphisms in GSTP1, GSTM1, and GSTT1 and susceptibility to colorectal cancer. Cancer Epidemiol Biomarkers Prev 1999, 8: 289-92. PMID: 10207630
  20. Jang Y, Lu SA, Chen ZP, Ma J, Xu CQ, Zhang CZ, et al. Genetic polymorphisms of CCND1 and PTEN in progression of esophageal squamous carcinoma. Genet Mol Res 2013; 12: 6685-91. doi: 10.4238/2013
  21. Potęga A. Glutathione-mediated conjugation of anticancer drugs: An overview of reaction mechanisms and biological significance for drug detoxification and bioactivation. Molecules 2022, 27: 5252. doi: 10.3390/molecules27165252
  22. Deng N, Zhou H, Fan H, Yuan Y. Single nucleotide polymorphisms and cancer susceptibility. Oncotarget 2017, 8: 110635. doi: 10.18632/oncotarget.22372
  23. Deng X, Hou J, Deng Q, Zhong Z. Predictive value of clinical toxicities of chemotherapy with fluoropyrimidines and oxaliplatin in colorectal cancer by DPYD and GSTP1 gene polymorphisms. World J Surg Oncol 2020, 18: 1-10. doi: 10.1186/s12957-020-02103-3
  24. Farmohammadi A, Arab-Yarmohammadi V, Ramzanpour R. Association analysis of rs1695 and rs1138272 variations in GSTP1 gene and breast cancer susceptibility. Asian Pac J Cancer Prev 2020; 21: 1167. doi: 10.31557/APJCP.2020.21.4.1167
  25. Kudhair BK, Abdulridha FM, Hussain GM, Lafta IJ, Alabid NN. The association of combined GSTM1, GSTT1, and GSTP1 genetic polymorphisms with lung cancer risk in male Iraqi Waterpipe Tobacco (Nargila) smokers. Cancer Epidemiol 2024; 93: 102689. doi: 10.1016/j.canep.2024.102689.
  26. Watson MA, Stewart RK, Smith GB, Massey TE, Bell DA. Human glutathione S-transferase P1 polymorphisms: relationship to lung tissue enzyme activity and population frequency distribution. Carcinogenesis 1998; 19: 275-80. doi: 10.1093/carcin/19.2.275
  27. Terrazzino S, La Mattina P, Masini L, Caltavuturo T, Gambaro G, Canonico PL, et al. Common variants of eNOS and XRCC1 genes may predict acute skin toxicity in breast cancer patients receiving radiotherapy after breast conserving surgery. Radiother Oncol 2012; 103: 199-205. doi: 10.1016/j.radonc.2011.12.002
  28. Osti MF, Nicosia L, Agolli L, Gentile G, Falco T, Bracci S, et al. Potential role of single nucleotide polymorphisms of XRCC1, XRCC3, and RAD51 in predicting acute toxicity in rectal cancer patients treated with preoperative radiochemotherapy. Am J Clin Oncol 2017; 40: 535-42. doi: 10.1097/COC.0000000000000182
  29. Rodrigues-Fleming GH, Fernandes GMM, Russo A, Biselli-Chicote PM, Netinho JG, Pavarino É, et al. Molecular evaluation of glutathione S transferase family genes in patients with sporadic colorectal cancer. World J Gastroenterol 2018; 24: 4462. doi: 10.3748/wjg.v24.i39.4462
  30. Khabaz MN, Al-Maghrabi JA, Nedjadi T, Gar MA, Bakarman M, Gazzaz ZJ, et al. Does Val/Val genotype of GSTP1 enzyme affects susceptibility to colorectal cancer in Saudi Arabia. Neuro Endocrinol Lett 2016; 37: 46-52. PMID: 26994385
  31. Gorukmez O, Yakut T, Gorukmez O, Sag SO, Topak A, Sahinturk S, et al. Glutathione S-transferase T1, M1 and P1 genetic polymorphisms and susceptibility to colorectal cancer in Turkey. Asian Pac J Cancer Prev 2016; 17: 3855-9. PMID: 27644629
  32. Vlaykova T, Miteva L, Gulubova M, Stanilova S. Ile 105 Val GSTP1 polymorphism and susceptibility to colorectal carcinoma in Bulgarian population. Int J Colorectal Dis 2007; 22: 1209-15. doi: 10.1007/s00384-007-0305-z
  33. Puerta-García E, Urbano-Pérez D, Carrasco-Campos MI, Pérez-Ramírez C, Segura-Pérez A, Calleja-Hernández, et al. Effect of DPYD, MTHFR, ABCB1, XRCC1, ERCC1 and GSTP1 on chemotherapy related toxicity in colorectal carcinoma. Surg Oncol 2020; 35: 388-98. doi: 10.1016/j.suronc.2020.09.016
  34. Klusek J, Nasierowska-Guttmejer A, Kowalik A, Wawrzycka I, Lewitowicz P, Chrapek M, et al. GSTM1, GSTT1, and GSTP1 polymorphisms and colorectal cancer risk in Polish nonsmokers. Oncotarget 2018; 9: 21224. doi: 10.18632/oncotarget.25031
  35. Liu J, Pan Y, Liu Y, Wei W, Hu X, Xin W, et al. The regulation of PTEN: Novel insights into functions as cancer biomarkers and therapeutic targets. J Cell Physiol 2023; 238: 1693-715. doi: 10.1002/jcp.31053
  36. Papa A, Pandolfi P. The PTEN–PI3K axis in cancer. Biomolecules 2019; 9: 153. doi: 10.3390/biom9040153
  37. Jang HY, Kim DH, Lee HJ, Kim WD, Kim SY, Hwang JJ, et al. Scheduledependent synergistic effects of 5-fluorouracil and selumetinib in KRAS or BRAF mutant colon cancer models. Biochem Pharmacol 2019; 160: 110-20. doi: 10.1016/j.bcp.2018.12.017
  38. Xu X, Chen G, Wu L, Liu L. Association of genetic polymorphisms in PTEN and additional gene–gene interaction with risk of esophageal squamous cell carcinoma in Chinese Han population. Dis Esophagus, 2016; 29: 944-9. doi: 10.1111/dote.12428
  39. Hassan MH, Nassar AY, Meki AMA, Nasser SA, Bakri AH, Radwan E. Pharmacogenetic study of phosphatase and tensin homolog polymorphism (rs701848) in childhood epilepsy: relation to circulating Wnt signaling. Neurol Res 2024; 46: 99-110. doi: 10.1080/01616412.2023.2257465
  40. Shek D, Read SA, Ahlenstiel G, Piatkov I. Pharmacogenetics of anticancer monoclonal antibodies. Cancer Drug Resistance 2019; 2: 69-81. doi: 10.20517/cdr.2018.20
DOI: https://doi.org/10.2478/raon-2025-0001 | Journal eISSN: 1581-3207 | Journal ISSN: 1318-2099
Language: English
Page range: 110 - 120
Submitted on: Jul 12, 2024
|
Accepted on: Oct 25, 2024
|
Published on: Jan 4, 2025
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2025 Durr-e-Shahwar, Hina Zubair, Muhammad Kashif Raza, Zahid Khan, Lamjed Mansour, Aktar Ali, Muhammad Imran, published by Association of Radiology and Oncology
This work is licensed under the Creative Commons Attribution 4.0 License.