FIGURE 1.
FIGURE 2.
FIGURE 3.
FIGURE 4.
Recommended preparation and dosing of intralesional injection (neat or foamed) of bleomycin for Bleomycin ElectroScleroTherapy (BEST)
| Concentration | Preparation for injection | Maximal dose per session | Cumulative dose in all sessions | |
|---|---|---|---|---|
| Bleomycin and contrast | 1 000 IU/ml in NaCl solution | 1 part of solution in 3 parts of Contrast Medium (250 IU/ml) | 10 000 IU in adults | 100 000 IU in adults |
| 200 IU/kg in children | 1 300 IU/kg in children-divided by number of sessions | |||
| Divide the total dose into anticipated number of sessions | ||||
| The interval between sessions should be at least 8 weeks | ||||
| Foamed bleomycin | 1 000 IU/ml in NaCl solution | 1 ml albumin; 1 ml plain 1% lidocaine; 8 000 IU bleomycin; contrast agent may be added; orthogonal 3 way tap connection; 5 ml air- or according to local practice | As above | As above |