The effects of normobaric and hyperbaric oxygenation on MRI signal intensities in T1-weighted, T2-weighted and FLAIR images in human brain Cover

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The effects of normobaric and hyperbaric oxygenation on MRI signal intensities in T1-weighted, T2-weighted and FLAIR images in human brain

Radiology and Oncology

Volume 57 (2023): Issue 3 (September 2023)

By: Vida Velej, Ksenija Cankar and Jernej Vidmar

Open Access

|Sep 2023

Figures & Tables

Hyperbaric oxygenation (HBO) protocol.

Representative MRI images in healthy subject at baseline, immediately after the end, after 25 min and after 50 min of NBO or HBO.

Comparison of T1-weighted signal intensities before, immediately, 25 min and 50 min after normobaric oxygenation (NBO) (A) and hyperbaric oxygenation (HBO) (B) (mean ± standard deviation)

A) NBO

Structure	Baseline	0 min	25 min	50 min	p
Frontal white matter	770.1 ± 251.2	791.0 ± 238.4	837.3 ± 328.4	851.3 ± 337.7^*	0.044
Thalamus	827.9 ± 275.6	846.7 ± 244.7	894.6 ± 338.4	914.7 ± 356.5^*	0.038
Head of caudate nucleus	731.9 ± 238.3	753.8 ± 227.0	798.7 ± 318.8	820.9 ± 331.3^*	0.023
Putamen	800.2 ± 257.0	814.2 ± 239.2	860.7 ± 333.8	878.1 ± 350.2	0.059
Hippocampus	701.6 ± 232.0	712.1 ± 211.3	751.8 ± 285.5	771.6 ± 303.8^*	0.038
Superior sagittal sinus	818.0 ± 375.6	748.2 ± 252.1	778.3 ± 288.6	860.9 ± 304.8	0.019
Cerebrospinal fluid	356.6 ± 126.8	362.7 ± 108.5	396.6 ± 152.9^*	397.7 ± 163.0^*	0.010
Vitreous body	281.3 ± 89.6	288.0 ± 92.1	296.8 ± 115.0	302.5 ± 116.3	0.264

B) HBO

Structure	Baseline	0 min	25 min	50 min	p
Frontal white matter	770.1 ± 251.2	834.7 ± 133.0	860.9 ± 158.9	886.6 ± 184.7^*	0.026
Thalamus	827.9 ± 275.6	900.8 ± 147.1	933.3 ± 169.1	957.1 ± 193.9^*	0.004
Head of caudate nucleus	731.9 ± 238.3	794.9 ± 124.4	819.9 ± 142.4	846.2 ± 173.7	0.013
Putamen	800.2 ± 257.0	867.1 ± 134.9	893.9 ± 154.6	922.5 ± 185.1^*	0.007
Hippocampus	701.6 ± 232.0	764.8 ± 124.1	787.2 ± 142.1	807.5 ± 163.2	0.044
Superior sagittal sinus	818.0 ± 375.6	848.0 ± 227.8	911.9 ± 310.7	907.6 ± 335.0	0.127
Cerebrospinal fluid	356.6 ± 126.8	396.4 ± 60.2	400.7 ± 73.7	413.0 ± 98.9	0.256
Vitreous body	281.3 ± 89.6	361.2 ± 63.0^*	335.9 ± 69.6	349.4 ± 82.8	0.040

Comparison of FLAIR signal intensities before, immediately, 25 min and 50 min after normobaric oxygenation (NBO) (A) and hyperbaric oxygenation (HBO) (B) (mean ± standard deviation)

A) NBO

Structure	Baseline	0 min	25 min	50 min	p
Frontal white matter	731.7 ± 77.0	700.8 ± 89.8	713.7 ± 125.1	717.4 ± 128.7	0.615
Thalamus	897.1 ± 101.7	851.5 ± 96.7	868.6 ± 164.3	861.5 ± 153.6	0.399
Head of caudate nucleus	1119.2 ± 131.9	1083.0 ± 129.4	1070.0 ± 213.0	1030.0 ± 172.5^*	0.039
Putamen	928.1 ± 116.5	875.8 ± 129.0	893.2 ± 184.3	893.0 ± 171.4	0.354
Hippocampus	1216.2 ± 135.7	1162.1 ± 144.8	1173.5 ± 223.0	1174.1 ± 239.1	0.490
Superior sagittal sinus	91.2 ± 23.6	84.6 ± 23.5	78.2 ± 27.2	86.0 ± 33.2	0.299
Cerebrospinal fluid	139.6 ± 33.3	140.5 ± 39.8	147.0 ± 51.8	157.8 ± 53.2	0.228
Vitreous body	127.2 ± 29.4	170.4 ± 49.1^*	157.3 ± 45.0^*	147.3 ± 45,9	0.002

B) HBO

Structure	Baseline	0 min	25 min	50 min	p
Frontal white matter	731.7 ± 77.0	755.8 ± 113.1	794.7 ± 135.2	782.2 ± 115.3	0.508
Thalamus	897.1 ± 101.7	927.1 ± 104.6	691.3 ± 127.3	949.7 ± 110.5	0.973
Head of caudate nucleus	1119.2 ± 131.9	1180.6 ± 183.3	1208.0 ± 175.8	1190.8 ± 152.3	0.508
Putamen	928.1 ± 116.5	958.3 ± 143.4	993.0 ± 148.2	978.9 ± 133.4	0.567
Hippocampus	1216.2 ± 135.7	1269.4 ± 171.3	1294.4 ± 184.7	1286.7 ± 160.4	0.771
Superior sagittal sinus	91.2 ± 23.6	93.4 ± 25.8	105.1 ± 30.5	106.4 ± 37.0	0.193
Cerebrospinal fluid	139.6 ± 33.3	134.5 ± 27.0	139.4 ± 20.2	138.3 ± 21.8	0.909
Vitreous body	127.2 ± 29.4	691.4 ± 142.9^*	523.6 ± 122.9^*	378.1 ± 88.8	< 0.001

Comparison of T2-weighted signal intensities before, immediately, 25 min and 50 min after normobaric oxygenation (NBO) (A) and hyperbaric oxygenation (HBO) (B) (mean ± standard deviation)

A) NBO

Structure	Baseline	0 min	25 min	50 min	p
Frontal white matter	362.5 ± 33.1	367.8 ± 32.8	397.1 ± 80.4^*	389.0 ± 51.3^*	0.007
Thalamus	480.6 ± 49.6	485.1 ± 63.5	521.0 ± 114.8	508.0 ± 61.7	0.022
Head of caudate nucleus	621.8 ± 64.8	637.9 ± 54.0	673.6 ± 139.8	656.7 ± 91.4	0.631
Putamen	514.0 ± 57.0	527.7 ± 50.7	552.3 ± 103.4	542.2 ± 64.1	0.073
Hippocampus	694.9 ± 71.9	712.6 ± 83.5	756.9 ± 190.3	734.0 ± 98.2	0.281
Superior sagittal sinus	41.3 ± 6.8	42.7 ± 8.6	45.7 ± 12.5	45.0 ± 11.3	0.317
Cerebrospinal fluid	1996.8 ± 143.6	2059.7 ± 203.3	2171.2 ± 522.0	2107.9 ± 274.3	0.318
Vitreous body	1404.8 ± 114.8	1499.4 ± 159.1	1585.5 ± 396.5	1520.9 ± 224.1	0.080

B) HBO

Structure	Baseline	0 min	25 min	50 min	p
Frontal white matter	362.5 ± 33.1	359.4 ± 26.7	367.0 ± 35.5	375.1 ± 44.7	0.223
Thalamus	480.6 ± 49.6	473.6 ± 34.4	479.3 ± 33.3	489.1 ± 59.1	0.365
Head of caudate nucleus	621.8 ± 64.8	617.8 ± 47.3	620.9 ± 50.0	639.5 ± 77.1	0.390
Putamen	514.0 ± 57.0	510.9 ± 37.1	514.6 ± 39.8	532.9 ± 65.4	0.256
Hippocampus	694.9 ± 71.9	695.9 ± 57.2	688.1 ± 38.4	713.4 ± 81.4	0.378
Superior sagittal sinus	41.3 ± 6.8	48.3 ± 14.0^*	47.4 ± 11.8	48.0 ± 15.0	0.047
Cerebrospinal fluid	1996.8 ± 143.6	1972.3 ± 79.2	1984.8 ± 102.3	2027.9 ± 195.4	0.482
Vitreous body	1404.8 ± 114.8	1524.0 ± 114.7^*	1529.5 ± 143.2^*	1530.9 ± 189.8^*	0.001

DOI: https://doi.org/10.2478/raon-2023-0043 | Journal eISSN: 1581-3207 | Journal ISSN: 1318-2099

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Language: English

Page range: 317 - 324

Submitted on: May 29, 2023

Accepted on: Jul 24, 2023

Published on: Sep 4, 2023

Published by: Association of Radiology and Oncology

In partnership with: Paradigm Publishing Services

Publication frequency: 4 issues per year

Keywords:

hyperbaric oxygen,

normobaric oxygen,

magnetic resonance,

Related subjects:

Clinical medicine,

Internal medicine,

Haematology, oncology,

© 2023 Vida Velej, Ksenija Cankar, Jernej Vidmar, published by Association of Radiology and Oncology
This work is licensed under the Creative Commons Attribution 4.0 License.

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