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The effects of normobaric and hyperbaric oxygenation on MRI signal intensities in T1-weighted, T2-weighted and FLAIR images in human brain Cover

The effects of normobaric and hyperbaric oxygenation on MRI signal intensities in T1-weighted, T2-weighted and FLAIR images in human brain

Radiology and Oncology
Volume 57 (2023): Issue 3 (September 2023)
By: ,   and    
Open Access
|Sep 2023
Figures & tables

Figures & Tables

FIGURE 1.

Hyperbaric oxygenation (HBO) protocol.

TABLE 1.

Comparison of T1-weighted signal intensities before, immediately, 25 min and 50 min after normobaric oxygenation (NBO) (A) and hyperbaric oxygenation (HBO) (B) (mean ± standard deviation)

A) NBO
StructureBaseline0 min25 min50 minp
Frontal white matter770.1 ± 251.2791.0 ± 238.4837.3 ± 328.4851.3 ± 337.7*0.044
Thalamus827.9 ± 275.6846.7 ± 244.7894.6 ± 338.4914.7 ± 356.5*0.038
Head of caudate nucleus731.9 ± 238.3753.8 ± 227.0798.7 ± 318.8820.9 ± 331.3*0.023
Putamen800.2 ± 257.0814.2 ± 239.2860.7 ± 333.8878.1 ± 350.20.059
Hippocampus701.6 ± 232.0712.1 ± 211.3751.8 ± 285.5771.6 ± 303.8*0.038
Superior sagittal sinus818.0 ± 375.6748.2 ± 252.1778.3 ± 288.6860.9 ± 304.80.019
Cerebrospinal fluid356.6 ± 126.8362.7 ± 108.5396.6 ± 152.9*397.7 ± 163.0*0.010
Vitreous body281.3 ± 89.6288.0 ± 92.1296.8 ± 115.0302.5 ± 116.30.264
B) HBO
StructureBaseline0 min25 min50 minp
Frontal white matter770.1 ± 251.2834.7 ± 133.0860.9 ± 158.9886.6 ± 184.7*0.026
Thalamus827.9 ± 275.6900.8 ± 147.1933.3 ± 169.1957.1 ± 193.9*0.004
Head of caudate nucleus731.9 ± 238.3794.9 ± 124.4819.9 ± 142.4846.2 ± 173.70.013
Putamen800.2 ± 257.0867.1 ± 134.9893.9 ± 154.6922.5 ± 185.1*0.007
Hippocampus701.6 ± 232.0764.8 ± 124.1787.2 ± 142.1807.5 ± 163.20.044
Superior sagittal sinus818.0 ± 375.6848.0 ± 227.8911.9 ± 310.7907.6 ± 335.00.127
Cerebrospinal fluid356.6 ± 126.8396.4 ± 60.2400.7 ± 73.7413.0 ± 98.90.256
Vitreous body281.3 ± 89.6361.2 ± 63.0*335.9 ± 69.6349.4 ± 82.80.040

* statistically significant difference compared to baseline value at p < 0.05; NBO = 100 % normobaric oxygen, HBO = 100 % hyperbaric oxygen

TABLE 2.

Comparison of T2-weighted signal intensities before, immediately, 25 min and 50 min after normobaric oxygenation (NBO) (A) and hyperbaric oxygenation (HBO) (B) (mean ± standard deviation)

A) NBO
StructureBaseline0 min25 min50 minp
Frontal white matter362.5 ± 33.1367.8 ± 32.8397.1 ± 80.4*389.0 ± 51.3*0.007
Thalamus480.6 ± 49.6485.1 ± 63.5521.0 ± 114.8508.0 ± 61.70.022
Head of caudate nucleus621.8 ± 64.8637.9 ± 54.0673.6 ± 139.8656.7 ± 91.40.631
Putamen514.0 ± 57.0527.7 ± 50.7552.3 ± 103.4542.2 ± 64.10.073
Hippocampus694.9 ± 71.9712.6 ± 83.5756.9 ± 190.3734.0 ± 98.20.281
Superior sagittal sinus41.3 ± 6.842.7 ± 8.645.7 ± 12.545.0 ± 11.30.317
Cerebrospinal fluid1996.8 ± 143.62059.7 ± 203.32171.2 ± 522.02107.9 ± 274.30.318
Vitreous body1404.8 ± 114.81499.4 ± 159.11585.5 ± 396.51520.9 ± 224.10.080
B) HBO
StructureBaseline0 min25 min50 minp
Frontal white matter362.5 ± 33.1359.4 ± 26.7367.0 ± 35.5375.1 ± 44.70.223
Thalamus480.6 ± 49.6473.6 ± 34.4479.3 ± 33.3489.1 ± 59.10.365
Head of caudate nucleus621.8 ± 64.8617.8 ± 47.3620.9 ± 50.0639.5 ± 77.10.390
Putamen514.0 ± 57.0510.9 ± 37.1514.6 ± 39.8532.9 ± 65.40.256
Hippocampus694.9 ± 71.9695.9 ± 57.2688.1 ± 38.4713.4 ± 81.40.378
Superior sagittal sinus41.3 ± 6.848.3 ± 14.0*47.4 ± 11.848.0 ± 15.00.047
Cerebrospinal fluid1996.8 ± 143.61972.3 ± 79.21984.8 ± 102.32027.9 ± 195.40.482
Vitreous body1404.8 ± 114.81524.0 ± 114.7*1529.5 ± 143.2*1530.9 ± 189.8*0.001

* statistically significant difference compared to baseline value at p < 0.05; NBO = 100 % normobaric oxygen; HBO = 100 % hyperbaric oxygen

TABLE 3.

Comparison of FLAIR signal intensities before, immediately, 25 min and 50 min after normobaric oxygenation (NBO) (A) and hyperbaric oxygenation (HBO) (B) (mean ± standard deviation)

A) NBO
StructureBaseline0 min25 min50 minp
Frontal white matter731.7 ± 77.0700.8 ± 89.8713.7 ± 125.1717.4 ± 128.70.615
Thalamus897.1 ± 101.7851.5 ± 96.7868.6 ± 164.3861.5 ± 153.60.399
Head of caudate nucleus1119.2 ± 131.91083.0 ± 129.41070.0 ± 213.01030.0 ± 172.5*0.039
Putamen928.1 ± 116.5875.8 ± 129.0893.2 ± 184.3893.0 ± 171.40.354
Hippocampus1216.2 ± 135.71162.1 ± 144.81173.5 ± 223.01174.1 ± 239.10.490
Superior sagittal sinus91.2 ± 23.684.6 ± 23.578.2 ± 27.286.0 ± 33.20.299
Cerebrospinal fluid139.6 ± 33.3140.5 ± 39.8147.0 ± 51.8157.8 ± 53.20.228
Vitreous body127.2 ± 29.4170.4 ± 49.1*157.3 ± 45.0*147.3 ± 45,90.002
B) HBO
StructureBaseline0 min25 min50 minp
Frontal white matter731.7 ± 77.0755.8 ± 113.1794.7 ± 135.2782.2 ± 115.30.508
Thalamus897.1 ± 101.7927.1 ± 104.6691.3 ± 127.3949.7 ± 110.50.973
Head of caudate nucleus1119.2 ± 131.91180.6 ± 183.31208.0 ± 175.81190.8 ± 152.30.508
Putamen928.1 ± 116.5958.3 ± 143.4993.0 ± 148.2978.9 ± 133.40.567
Hippocampus1216.2 ± 135.71269.4 ± 171.31294.4 ± 184.71286.7 ± 160.40.771
Superior sagittal sinus91.2 ± 23.693.4 ± 25.8105.1 ± 30.5106.4 ± 37.00.193
Cerebrospinal fluid139.6 ± 33.3134.5 ± 27.0139.4 ± 20.2138.3 ± 21.80.909
Vitreous body127.2 ± 29.4691.4 ± 142.9*523.6 ± 122.9*378.1 ± 88.8< 0.001

* statistically significant difference compared to baseline value at p < 0.05; NBO = 100 % normobaric oxygen; HBO = 100 % hyperbaric oxygen

FIGURE 2.

Representative MRI images in healthy subject at baseline, immediately after the end, after 25 min and after 50 min of NBO or HBO.

DOI: https://doi.org/10.2478/raon-2023-0043 | Journal eISSN: 1581-3207 | Journal ISSN: 1318-2099
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Language: English
Page range: 317 - 324
Submitted on: May 29, 2023
Accepted on: Jul 24, 2023
Published on: Sep 4, 2023
Published by: Association of Radiology and Oncology
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year
Keywords:
hyperbaric oxygen,
normobaric oxygen,
magnetic resonance,
human brain
Related subjects:
Medicine,
Clinical medicine,
Radiology

© 2023 Vida Velej, Ksenija Cankar, Jernej Vidmar, published by Association of Radiology and Oncology
This work is licensed under the Creative Commons Attribution 4.0 License.

Volume 57 (2023): Issue 3 (September 2023)
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