Comparing the diagnostic efficacy of [18F]FDG PET/CT and [18F]FDG PET/MRI for detecting bone metastases in breast cancer: a meta-analysis

Longjie Xia; Jianqin Lai; Di Huang; Shenghui Qiu; Huiqiong Hu; Yunxiang Luo; Jie Cao

doi:10.2478/raon-2023-0037

Figures & Tables

PRISMA flow diagram illustrating the study selection process.FN = false negative; FP = false positive; TN = true negative; TP = true positive

Risk of bias and applicability concerns of the included studies using the Quality Assessment of Diagnostic Performance Studies QUADAS-2 tool.

Forest plot showing the pooled sensitivities of [18F]FDG PET/CT and [18F]FDG PET/MRI in bone metastasis of breast cancer patients on a patient-based analysis. The plot displays individual study estimates (squares) with corresponding 95% confidence intervals (horizontal lines) and the pooled sensitivity estimate (diamond) for both modalities. The size of the squares represents the relative weight of each study in the meta-analysis.9,15,17,18,21,23,25

Forest plot showing the pooled sensitivities of [18F]FDG PET/CT and [18F]FDG PET/MRI in bone metastasis of breast cancer patients on a lesion-based analysis. The plot displays individual study estimates (squares) with corresponding 95% confidence intervals (horizontal lines) and the pooled sensitivity estimate (diamond) for both modalities. The size of the squares represents the relative weight of each study in the meta-analysis.9,10,11,18,19,20,22,23,24,25,26,27

Forest plot showing the pooled specificities of [18F]FDG PET/CT and [18F]FDG PET/MRI in bone metastasis of breast cancer patients on a patient-based analysis. The plot displays individual study estimates (squares) with corresponding 95% confidence intervals (horizontal lines) and the pooled specificity estimate (diamond) for both modalities. The size of the squares represents the relative weight of each study in the meta-analysis.9,15,17,18,21,23,25

Forest plot showing the pooled specificities of [18F]FDG PET/CT and [18F]FDG PET/MRI in bone metastasis of breast cancer patients on a lesion-based analysis. The plot displays individual study estimates (squares) with corresponding 95% confidence intervals (horizontal lines) and the pooled specificity estimate (diamond) for both modalities. The size of the squares represents the relative weight of each study in the meta-analysis.9,18,19,20,21,23,25,26,27

Study and patient characteristics of the included studies for [18F]FDG PET/CT

Author	Year	Type of imaging test	Study characteristics					Patient characteristics

			Country	Study design	Analysis	Reference standard	No. of patients	Clinical indication	Mean/Median age	Previous treatment
Catalano et al.¹⁵	2015	PET/CT	Italy	Retro	PB	Pathology and/or follow-up imaging	109	Initial stage and post-treatment stage	Mean ± SD: (58.08 ± 10.7)	Surgery
Melsaether et al.¹⁰	2016	PET/CT	USA	Pro	LB	Pathology and/or follow-up imaging	51	Initial stage and post-treatment stage	Mean(range): 56 (32–76)	Chemotherapy
Botsikas et al.⁹	2018	PET/CT	Switzerland	Pro	PB and LB	Pathology and/or follow-up imaging	80	Initial stage and post-treatment stage	Mean ± SD: (48 ± 12.9)	NA
Sawicki et al.¹¹	2016	PET/CT	Germany	Pro	LB	Pathology and/or follow-up imaging	21	Post-treatment stage	Mean ± SD: (59.4 ±11.5)	NA
Balci et al.¹⁷	2012	PET/CT	Turkey	Retro	PB	Pathology and/or follow-up imaging	162	Initial stage and post-treatment stage	Mean: 50.6	Surgery
Hahn et al.¹⁸	2011	PET/CT	Germany	Retro	PB and LB	Follow-up imaging	29	Initial stage	Mean (range): 57.5 (35–78)	NA
Manohar et al.¹⁹	2012	PET/CT	India	Retro	LB	Pathology and/or follow-up imaging	111	Post-treatment stage	Mean(range): 52 (22–80)	Surgery
Niikura et al.²⁵	2011	PET/CT	Japan	Retro	LB	Pathology and/or follow-up imaging	225	Initial stage and post-treatment stage	Mean: 53.4	Chemotherapy or endocrine therapy
Riegger et al.²²	2012	PET/CT	Germany	Retro	LB	Pathology and/or follow-up imaging	106	Initial stage	Mean ± SD: (57 ± 13)	NA
Rager et al.²³	2018	PET/CT	Switzerland	Retro	PB and LB	Follow-up imaging	25	Initial stage and post-treatment stage	Median(range): 5 (38–82)	NA
Demir et al.²⁰	2014	PET/CT	Turkey	Retro	LB	Pathology and/or follow-up imaging	50	Post-treatment stage	Mean ± SD: (53.9 ± 12.3)	NA
Hansen et al.²⁴	2015	PET/CT	Denmark	Pro	LB	Pathology	18	Post-treatment stage	Mean(range): 61.5 (38–76)	Surgery
Niikura et al.²¹	2016	PET/CT	Japan	Pro	PB	Pathology and/or follow-up imaging	28	Initial stage and post-treatment stage	Median(range): 59 (31–76)	Surgery
Shawky et al.²⁶	2016	PET/CT	Egypt	Pro	LB	Pathology and/or follow-up imaging	30	Post-treatment stage	Mean(range): 53.5 (33–73)	Surgery or Chemotherapy or radiotherapy
Teke et al.²⁷	2020	PET/CT	Turkey	Retro	LB	Follow-up imaging	62	Initial stage	Median(range): 44.5 (8–81)	NO

Study and patient characteristics of the included studies for [18F]FDG PET/MRI

Author	Year	Type of imaging test	Study characteristics				Patient characteristics

			Country	Study design	Analysis	Reference standard	No. of patients	Clinical indication	Mean/Median age	Previous treatment
Catalano et al.¹⁵	2015	PET/MRI	Italy	Retro	PB	Pathology and/or follow-up imaging	109	Initial stage and post-treatment stage	Mean ± SD: (58.08 ± 10.7)	Surgery
Bruckmann et al.²¹	2021	PET/MRI	Germany	Pro	PB and LB	Pathology	154	Post-treatment stage	Mean ± SD: (53.8±11.9)	NO
Melsaether et al.¹⁰	2016	PET/MRI	USA	Pro	LB	Pathology and/or follow-up imaging	51	Initial stage and post-treatment stage	Mean(range): 56(32–76)	Chemotherapy
Botsikas et al.⁹	2018	PET/MRI	Switzerland	Pro	PB and LB	Pathology and/or follow-up imaging	80	Initial stage and post-treatment stage	Mean ± SD: (48 ± 12.9)	NA
Sawicki et al.¹¹	2016	PET/MRI	Germany	Pro	LB	Pathology and/or follow-up imaging	21	Post-treatment stage	Mean ± SD: (59.4 ± 11.5)	NA

Comparing the diagnostic efficacy of [18F]FDG PET/CT and [18F]FDG PET/MRI for detecting bone metastases in breast cancer: a meta-analysis

Figures & Tables

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Study and patient characteristics of the included studies for [18F]FDG PET/CT

Study and patient characteristics of the included studies for [18F]FDG PET/MRI

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