FIGURE 1.
FIGURE 2.
FIGURE 3.
Treatment of patients and their outcome
| Factor | Subgroup | All patients (N = 28) | Without Graves’ disease (N = 24) | With Graves’ disease (N = 4) | p-value |
|---|---|---|---|---|---|
| Thyroid surgery | No | 8 | 7 | 1 | 1.00 |
| Yes | 20 | 17 | 3 | ||
| Thyroid surgical procedure | Total or near-total thyroidectomy Lobectomy or less | 18 | 15 | 3 | 1.00 |
| 10 | 9 | 1 | |||
| Residual tumor after surgery | No surgery | 8 | 7 | 1 | 0.916 |
| R0 (without residual tumor) | 11 | 9 | 2 | ||
| R1 | 2 | 2 | 0 | ||
| R2 | 7 | 6 | 1 | ||
| Neck dissection | No | 24 | 21 | 3 | 0.481 |
| Yes | 4 | 3 | 1 | ||
| Surgery of distant metastases | No | 26 | 24 | 2 | 0.016 |
| Yes | 2 | 0 | 2 | ||
| RAI ablation after surgery | No | 10 | 9 | 1 | 1.00 |
| Yes | 18 | 15 | 3 | ||
| Therapy with RAI | No | 10 | 9 | 1 | 1.00 |
| Yes | 18 | 15 | 3 | ||
| EBRT to the neck | No | 21 | 17 | 4 | 0.545 |
| Yes | 7 | 7 | 0 | ||
| EBRT (any site) | No | 15 | 13 | 2 | 1.00 |
| Yes | 13 | 11 | 2 | ||
| Preoperative chemotherapy | No | 25 | 23 | 2 | 0.045 |
| Yes | 3 | 1 | 2 | ||
| Chemotherapy | No | 22 | 20 | 2 | 0.191 |
| Yes | 6 | 4 | 2 | ||
| Targeted therapy | No | 18 | 16 | 2 | 0.601 |
| Yes | 10 | 8 | 2 | ||
| Outcome | Alive with disease | 9 | 7 | 2 | 0.461 |
| Dead of disease | 15 | 14 | 1 | ||
| Dead of other causes | 4 | 3 | 1 |
Clinical characteristics and pathological characteristics of tumors
| Factor | Subgroup | All patients (N = 28) | Without Graves’ disease (N = 24) | With Graves’ disease (N = 4) | p-value |
|---|---|---|---|---|---|
| Mean age of patients (year) | 73.86 | 74.25 | 71.50 | 0.359 | |
| Mean primary tumor size (cm) | 5.604 | 5.483 | 6.325 | 0.355 | |
| Gender | Female | 20 | 19 | 1 | 0.058 |
| Male | 8 | 5 | 3 | ||
| Age (years) | 54 or less | 1 | 1 | 0 | 1.00 |
| 55 or more | 27 | 23 | 4 | ||
| Hyperthyreosis at presentation | No | 23 | 23 | 0 | 0.001 |
| Yes | 5 | 1 | 4 | ||
| Functional metastases | No | 26 | 24 | 2 | 0.016 |
| Yes | 2 | 0 | 2 | ||
| Tumor diameter (cm) | 0–4 | 9 | 8 | 1 | 1.00 |
| 4.01 and more | 19 | 16 | 3 | ||
| pT tumor stage | pTx, pT1 or pT2 | 7 | 6 | 1 | 0.522 |
| pT3 | 7 | 5 | 2 | ||
| pT4 | 14 | 13 | 1 | ||
| N stage | N0 | 20 | 17 | 3 | 1.00 |
| N1 or N2 | 8 | 7 | 1 | ||
| M stage | M0 | 0 | 0 | 0 | - |
| M1 | 28 | 24 | 4 | ||
| Type of metastases | Lung only | 11 | 10 | 1 | 0.759 |
| Bones and others | 12 | 9 | 3 | ||
| Lungs and others without bones | 5 | 5 | 0 | ||
| Single organ metastases | No | 14 | 11 | 3 | 0.596 |
| Yes | 14 | 13 | 1 | ||
| Tumor type | Papillary | 14 | 12 | 1 | 0.279 |
| Hürthle | 6 | 4 | 2 | ||
| Follicular | 5 | 5 | 0 | ||
| Poorly differentiated | 3 | 3 | 1 | ||
| Tumor differentiation (N = 19) | Well | 6 | 5 | 1 | 1.00 |
| Moderate or poor | 13 | 12 | 1 |