Radiological assessment of skeletal muscle index and myosteatosis and their impact postoperative outcomes after liver transplantation
References
- Starzl TE, Marchioro TL, Vonkaulla KN, Hermann G, Brittain RS, Waddell WR. Homotransplantation of the liver in humans. Surg Gynecol Obstet 1963; 117: 659–76. PMID: 14100514
- Song AT, Avelino-Silva VI, Pecora RA, Pugliese V, D’Albuquerque LA, Abdala E. Liver transplantation: fifty years of experience. World J Gastroenterol 2014; 20: 5363–74. doi: 10.3748/wjg.v20.i18.5363
- Polyak A, Kuo A, Sundaram V. Evolution of liver transplant organ allocation policy: current limitations and future directions. World J Hepatol 2021; 13: 830–9. doi: 10.4254/with.v13.i8.830
- Deng M, Ng SWY, Cheung ST, Chong CCN. Clinical application of Albumin-Bilirubin (ALBI) scores: the current status. Surgeon 2020; 18: 178–86. doi: 10.1016/j.surge.2019.09.002
- Cruz-Jentoft AJ, Bahat G, Bauer J, Boirie Y, Bruyère O, Cederholm T, et al. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing 2019; 48: 16–31. doi: 10.1093/ageing/afy169
- Reginster JY, Beaudart C, Al-Daghri N, Avouac B, Bauer J, Bere N, et al. Update on the ESCEO recommendation for the conduct of clinical trials for drugs aiming at the treatment of sarcopenia in older adults. Aging Clin Exp Res 2021; 33: 3–17. doi: 10.1007/s40520-020-01663-4
- Delmonico MJ, Harris TB, Visser M, Park SW, Conroy MB, Velasquez-Mieyer P, et al. Health, aging, and body. Longitudinal study of muscle strength, quality, and adipose tissue infiltration. Am J Clin Nutr 2009; 90: 1579–85. doi: 10.3945/ajcn.2009.28047
- Miljkovic I, Kuipers AL, Cvejkus R, Bunker CH, Patrick AL, Gordon CL, el al. Myosteatosis increases with aging and is associated with incident diabetes in African ancestry men. Obesity 2016; 24: 476–82. doi: 10.1002/oby.21328
- Montano-Loza AJ, Angulo P, Meza-Junco J, Prado CM, Sawyer MB, Beaumont C, et al. Sarcopenic obesity and myosteatosis are associated with higher mortality in patients with cirrhosis. J Cachexia Sarcopenia Muscle 2015; 7: 126–35. doi: 10.1002/jcsm.12039
- Goodpaster BH, Theriault R, Watkins SC, Kelley DE. Intramuscular lipid content is increased in obesity and decreased by weight loss. Metabolism 2000; 49: 467–72. doi: 10.1016/s0026-0495(00)80010-4
- Lee CM, Kang J. Prognostic impact of myosteatosis in patients with colorectal cancer: a systematic review and meta-analysis. J Cachexia Sarcopenia Muscle 2020; 11: 1270–82. doi: 10.1002/jcsm.12575
- Srpcic M, Jordan T, Popuri K, Sok M. Sarcopenia and myosteatosis at presentation adversely affect survival after esophagectomy for esophageal cancer. Radiol Oncol 2020; 54: 237–46. doi: 10.2478/raon-2020-0016
- Espinosa-Flores AJ, Guzman-Ortiz E, Melendez-Mier G, Ternovoy SK, Bueno-Hernandez N, Roldan-Valadez E. A scoping review of the methods used in patients with liver cirrhosis to assess body composition and their nutritional findings. [Ahead of print]. Eur J Clin Nutr 2023. doi:10.1038/s41430-023-01287-7
- Lee CM, Kang BK, Kim M. Radiologic definition of sarcopenia in chronic liver disease. Life (Basel) 2021; 11: 86. doi: 10.3390/life11020086
- Kjønigsen LJ, Harneshaug M, Fløtten AM, Karterud LK, Petterson K, Skjolde G, et al. Reproducibility of semiautomated body composition segmentation of abdominal computed tomography: a multiobserver study. Eur Radiol Exp 2019; 3: 42. doi: 10.1186/s41747-019-0122-5
- Jensen GL, Cederholm T, Correia MITD, Gonzalez MC, Fukushima R, Higashiguchi T, et al. GLIM criteria for the diagnosis of malnutrition: a consensus report from the global clinical nutrition community. JPEN J Parenter Enteral Nutr 2019; 43: 32–40. doi: 10.1002/jpen.1440
- Song HN, Wang WB, Luo X, Huang DD, Ruan XJ, Xing CG, et al. Effect of GLIM-defined malnutrition on postoperative clinical outcomes in patients with colorectal cancer. Jpn J Clin Oncol 2022; 52: 466–74. doi: 10.1093/jjco/hyab215.
- Dindo D, Demartines N, Clavien PA. Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg 2004; 240: 205–13. doi: 10.1097/01.sla.0000133083.54934.ae
- Venturi C, Sempoux C, Bueno J, Ferreres Pinas JC, Bourdeaux C, Abarca-Quinones J, et al. Novel histologic scoring system for long-term allograft fibrosis after liver transplantation in children. Am J Transplant 2012; 12: 2986–96. doi: 10.1111/j.1600-6143.2012.04210.x
- Popuri K, Cobzas D, Esfandiari N, Baracos V, Jagersand M. Body composition assessment in axial CT images using FEM-based automatic segmentation of skeletal muscle. IEEE Trans Med Imaging 2016; 35: 512–20. doi: 10.1109/TMI.2015.2479252
- van Vugt JL, Levolger S, de Bruin RW, van Rosmalen J, Metselaar HJ, IJzermans JN. Systematic review and meta-analysis of the impact of computed tomography-assessed skeletal muscle mass on outcome in patients awaiting or undergoing liver transplantation. Am J Transplant 2016; 16: 2277–92. doi: 10.1111/ajt.13732
- Ebadi M, Tsien C, Bhanji RA, Dunichand-Hoedl AR, Rider E, Motamedrad M, et al. Myosteatosis in cirrhosis: a review of diagnosis, pathophysiological mechanisms and potential interventions. Cells 2022; 11: 1216. doi: 10.3390/cells11071216
- Eslamparast T, Montano-Loza AJ, Raman M, Tandon P. Sarcopenic obesity in cirrhosis − the confluence of 2 prognostic titans. Liver Int 2018; 38: 1706–17. doi: 10.1111/liv.13876
- Czigany Z, Kramp W, Bednarsch J, van der Kroft G, Boecker J, Strnad P, et al. Myosteatosis to predict inferior perioperative outcome in patients undergoing orthotopic liver transplantation. Am J Transplant 2020; 20: 493–503. doi: 10.1111/ajt.15577
- Dasarathy S, Merli M. Sarcopenia from mechanism to diagnosis and treatment in liver disease. J Hepatol 2016; 65: 1232–44. doi: 10.1016/j.jhep.2016.07.040
- Ebadi M, Bhanji RA, Mazurak VC, Montano-Loza AJ. Sarcopenia in cirrhosis: from pathogenesis to interventions. J Gastroenterol 2019; 54: 845–59. doi:10.1007/s00535-019-01605-6
- Montano-Loza AJ. Skeletal muscle abnormalities and outcomes after liver transplantation. Liver Transpl 2014; 20: 1293–95. doi: 10.1002/lt.23995
- Kim HY, Jang JW. Sarcopenia in the prognosis of cirrhosis: going beyond the MELD score. World J Gastroenterol 2015; 21: 7637–47. doi: 10.3748/wjg.v21.i25.7637
- Levolger S, van Vugt JLA, de Bruin RWF, IJzermans JNM. Systematic review of sarcopenia in patients operated on for gastrointestinal and hepatopancreatobiliary malignancies. Br J Surg 2015, 102: 1448–58. doi: 10.1002/bjs.9893
- Cao Q, Xiong Y, Zhong Z, Ye Q. Computed tomography-assessed sarcopenia indexes predict major complications following surgery for hepatopancreatobiliary malignancy: a meta-analysis. Ann Nutr Metab 2019; 74: 24–34. doi: 10.1159/000494887
- Kaibori M, Ishizaki M, Iida H, Matsui K, Sakaguchi T, Inoue K, et al. Effect of intramuscular adipose tissue content on prognosis in patients undergoing hepatocellular carcinoma resection. J Gastrointest Surg 2015; 19: 1315–23. doi: 10.1007/s11605-015-2838-8
- Ooi PH, Hager A, Mazurak VC, Dajani K, Bhargava R, Gilmour SM, et al. Sarcopenia in chronic liver disease: impact on outcomes. Liver Transpl 2019; 25: 1422–38. doi: 10.1002/lt.25591
- Weerink LBM, van der Hoorn A, van Leeuwen BL, de Bock GH. Low skeletal muscle mass and postoperative morbidity in surgical oncology: a systematic review and meta-analysis. J Cachexia Sarcopenia Muscle 2020; 11: 636–49. doi: 10.1002/jcsm.12529
- Hsu CS, Kao JH. Sarcopenia and chronic liver diseases. Expert Rev Gastroenterol Hepatol 2018; 12: 1229–44. doi: 10.1080/17474124.2018.1534586
- Pinto Dos Santos D, Kloeckner R, Koch S, Hoppe-Lotichius M, Zöller D, Toenges G, et al. Sarcopenia as prognostic factor for survival after orthotopic liver transplantation. Eur J Gastroenterol Hepatol 2020; 32: 626–34. doi: 10.1097/MEG.0000000000001552
- Montano-Loza AJ, Meza-Junco J, Prado CM, Lieffers JR, Baracos VE, Bain VG, et al. Muscle wasting is associated with mortality in patients with cirrhosis. Clin Gastroenterol Hepatol 2012; 10: 166–73, 173.e1. doi: 10.1016/j.cgh.2011.08.028
- Lucidi C, Lattanzi B, Di Gregorio V, Incicco S, D’Ambrosio D, Venditti M, et al. A low muscle mass increases mortality in compensated cirrhotic patients with sepsis. Liver Int 2018; 38: 851–7. doi: 10.1111/liv.13691
- Chang KV, Chen JD, Wu WT, Huang KC, Lin HY, Han DS. Is sarcopenia associated with hepatic encephalopathy in liver cirrhosis? A systematic review and meta-analysis. J Formos Med Assoc 2019; 118: 833–42. doi: 10.1016/j.jfma.2018.09.011
- Lattanzi B, D’Ambrosio D, Merli M. Hepatic encephalopathy and sarcopenia: two faces of the same metabolic alteration. J Clin Exp Hepatol 2019; 9: 125–13. doi: 10.1016/j.jceh.2018.04.007
- Dhaliwal A, Larson D, Hiat M, Muinov LM, Harrison WL, Sayles H, et al. Impact of sarcopenia on mortality in patients undergoing liver re-transplantation. World J Hepatol 2020; 12: 807–15. doi: 10.4254/wjh.v12.i10.807
- Lee CM, Kang BK, Kim M. Radiologic definition of sarcopenia in chronic liver disease. Life 2021; 11: 86. doi: 10.3390/life11020086
- Meeks AC, Madill J. Sarcopenia in liver transplantation: a review. Clin Nutr ESPEN 2017; 22: 76–80. doi: 10.1016/j.clnesp.2017.08.005
- van Vugt JL, Levolger S, de Bruin RW, van Rosmalen J, Metselaar HJ, IJzermans JN. Systematic review and meta-analysis of the impact of computed tomography-assessed skeletal muscle mass on outcome in patients awaiting or undergoing liver transplantation. Am J Transplant 2016; 16: 2277–92. doi: 10.1111/ajt.13732
- Yao J, Zhou X, Yuan L, Niu LY, Zhang A, Shi H, et al. Prognostic value of the third lumbar skeletal muscle mass index in patients with liver cirrhosis and ascites. Clin Nutr 2020; 39: 1908–13. doi: 10.1016/j.clnu.2019.08.006
- Kappus MR, Wegermann K, Bozdogan E, Patel YA, Janas G, Shropshire E, et al. Use of skeletal muscle index as a predictor of wait-list mortality in patients with end-stage liver disease. Liver Transpl 2020; 26: 1090–9. doi: 10.1002/lt.25802
- Aby ES, Lee E, Saggi SS, Viramontes MR, Grotts JF, Agopian VG, et al. Pretransplant sarcopenia in patients with NASH cirrhosis does not impact rehospitalization or mortality. J Clin Gastroenterol 2019; 53: 680–5. doi: 10.1097/MCG.0000000000001109
- Czigany Z, Kramp W, Lurje I, Miller H, Bednarsch J, Lang SA, et al. The role of recipient myosteatosis in graft and patient survival after deceased donor liver transplantation. J Cachexia Sarcopenia Muscle 2021; 12: 358–67. doi: 10.1002/jcsm.12669
- Nelke C, Dziewas R, Minnerup J, Meuth SG, Ruck T. Skeletal muscle as potential central link between sarcopenia and immune senescence. EBioMedicine 2019; 49: 381–8. doi: 10.1016/j.ebiom.2019.10.034
- Wakabayashi T, Shinoda M, Obara H, Kitago M, Yagi H, Abe Y, et al. Decreased incidence of acute cellular rejection in low-muscle-mass recipients after living-donor liver transplantation. Transplant Proc 2018; 50: 3626–34. doi: 10.1016/j.transproceed.2018.06.028
- Bellido D, García-García C, Talluri A, Lukaski HC, García-Almeida JM. Future lines of research on phase angle: strengths and limitations. Rev Endocr Metab Disord 2023; 24: 563–83. doi: 10.1007/s11154-023-09803-7
- Lee CM, Kang BK, Kim M. Radiologic definition of sarcopenia in chronic liver disease. Life 2021; 11: 86. doi: 10.3390/life11020086
- Kallwitz ER. Sarcopenia and liver transplant: the relevance of too little muscle mass. World J Gastroenterol 2015; 21: 10982–93. doi: 10.3748/wjg.v21.i39.10982
- Lindqvist C, Brismar TB, Majeed A, Wahlin S. Assessment of muscle mass depletion in chronic liver disease: dual-energy x-ray absorptiometry compared with computed tomography. Nutrition 2019; 61: 93–8. doi: 10.1016/j.nut.2018.10.031
- Shenvi SD, Taber DJ, Hardie AD, Botstein JO, McGillicuddy JW. Assessment of magnetic resonance imaging derived fat fraction as a sensitive and reliable predictor of myosteatosis in liver transplant recipients. HPB (Oxford) 2020; 22: 102–8. doi: 10.1016/j.hpb.2019.06.006
- Ahn H, Kim DW, Ko Y, Ha J, Shin YB, Lee J, et al. Updated systematic review and meta-analysis on diagnostic issues and the prognostic impact of myosteatosis: a new paradigm beyond sarcopenia. Ageing Res Rev 2021; 70: 101398. doi: 10.1016/j.arr.2021.101398
- Martin L, Birdsell L, Macdonald N, Reiman T, Clandinin MT, McCargar LJ, et al. Cancer cachexia in the age of obesity: skeletal muscle depletion is a powerful prognostic factor, independent of body mass index. J Clin Oncol 2013; 31:1539–47. doi: 10.1200/JCO.2012.45.2722
- Loosen SH, Schulze-Hagen M, Püngel T, Bündgens L, Wirtz T, Kather JN, et al. Skeletal muscle composition predicts outcome in critically Ill patients. Crit Care Explor 2020; 2: e0171. doi: 10.1097/CCE.0000000000000171
- Kim HY, Jang JW. Sarcopenia in the prognosis of cirrhosis: going beyond the MELD score. World J Gastroenterol 2015; 21: 7637–47. doi: 10.3748/wjg.v21.i25.7637
- Francoz C, Prié D, Abdelrazek W, Moreau R, Mandot A, Belghiti J, et al. Inaccuracies of creatinine and creatinine-based equations in candidates for liver transplantation with low creatinine: impact on the model for end-stage liver disease score. Liver Transpl 2010; 16: 1169–77. doi: 10.1002/lt.22128
- Hamaguchi Y, Kaido T, Okumura S, Kobayashi A, Shirai H, Yao S, et al. Including body composition in MELD scores improves mortality prediction among patients awaiting liver transplantation. Clin Nutr 2020; 39: 1885–92. doi: 10.1016/j.clnu.2019.08.012
- Montano-Loza AJ, Duarte-Rojo A, Meza-Junco J, Baracos VE, Sawyer MB, Pang JX, et al. Inclusion of sarcopenia within MELD (MELD-Sarcopenia) and the prediction of mortality in patients with cirrhosis. Clin Transl Gastroenterol 2015; 6: e102. doi: 10.1038/ctg.2015.31
- van Vugt JLA, Alferink LJM, Buettner S, Gaspersz MP, Bot D, Darwish Murad S, et al. A model including sarcopenia surpasses the MELD score in predicting waiting list mortality in cirrhotic liver transplant candidates: a competing risk analysis in a national cohort. J Hepatol 2018; 68: 707–14. doi: 10.1016/j.jhep.2017.11.030
- Chedid MF, Picon RV, Chedid AD. ALBI and PALBI: novel scores for outcome prediction of cirrhotic outpatients awaiting liver transplantation. Ann Hepatol 2018; 17: 906–7. doi: 10.5604/01.3001.0012.7190
- Bernardi N, Chedid MF, Grezzana-Filho TJM, Chedid AD, Pinto MA, Leipnitz I, et al. Pre-transplant ALBI grade 3 is associated with increased mortality after liver transplantation. Dig Dis Sci 2019; 64: 1695–704. doi: 10.1007/s10620-019-5456-6
- Miarka M, Gibiński K, Janik MK, Główczyńska R, Zając K, Pacho R, et al. Sarcopenia-the impact on physical capacity of liver transplant patients. Life 2021; 11: 740. doi: 10.3390/life11080740.
- European Association for the Study of the Liver. EASL Clinical Practice Guidelines on nutrition in chronic liver disease. J Hepatol 2019; 70: 172–93. doi: 10.1016/j.jhep.2018.06.024
- Maharshi S, Sharma BC, Sachdeva S, Srivastava S, Sharma P. Efficacy of nutritional therapy for patients with cirrhosis and minimal hepatic encephalopathy in a randomized trial. Clin Gastroenterol Hepatol 2016; 14: 454–60. e453. doi: 10.1016/j.cgh.2015.09.028
- Ebadi M, Bhanji RA, Mazurak VC, Montano-Loza AJ. Sarcopenia in cirrhosis: from pathogenesis to interventions. J Gastroenterol 2019; 54: 845–59. doi: 10.1007/s00535-019-01605-6
- Dasarathy S, Merli M. Sarcopenia from mechanism to diagnosis and treatment in liver disease. J Hepatol 2016; 65: 1232–44. doi: 10.1016/j.jhep.2016.07.040
- Berzigotti A, Albillos A, Villanueva C, Genesca J, Ardevol A, Augustin S, et al. Effects of an intensive lifestyle intervention program on portal hypertension in patients with cirrhosis and obesity: the SportDiet study. Hepatology 2017; 65: 1293–305. doi: 10.1002/hep.28992
- Stokes CS, Volmer DA, Grunhage F, Lammert F. Vitamin D in chronic liver disease. Liver Int 2013; 33: 338–52. doi: 10.1111/liv.12106
- Miarka M, Gibiński K, Janik MK, Główczyńska R, Zając K, Pacho R, et al. Sarcopenia-the Impact on physical capacity of liver transplant patients. Life 2021; 11: 740. doi: 10.3390/life11080740
- Lei Q, Wang X, Zheng H, Bi J, Tan S, Li N. Peri-operative immunonutrition in patients undergoing liver transplantation: a meta-analysis of randomized controlled trials. Asia Pac J Clin Nutr 2015; 24: 583–90. doi: 10.6133/apjcn.2015.24.4.20.
Language: English
Page range: 168 - 177
Submitted on: Mar 12, 2023
Accepted on: May 16, 2023
Published on: Jun 21, 2023
Published by: Association of Radiology and Oncology
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© 2023 Miha Petric, Taja Jordan, Popuri Karteek, Sabina Licen, Blaz Trotovsek, Ales Tomazic, published by Association of Radiology and Oncology
This work is licensed under the Creative Commons Attribution 4.0 License.