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Correlation of mean apparent diffusion coefficient (ADC) and maximal standard uptake value (SUVmax) evaluated by diffusion-weighted MRI and 18F-FDG-PET/CT in children with Hodgkin lymphoma: a feasibility study Cover

Correlation of mean apparent diffusion coefficient (ADC) and maximal standard uptake value (SUVmax) evaluated by diffusion-weighted MRI and 18F-FDG-PET/CT in children with Hodgkin lymphoma: a feasibility study

Open Access
|Jun 2023

Figures & Tables

FIGURE 1.

Flowchart for recruitment of study subjects according to the Standards for Reporting of Diagnostic Accuracy (STARD) studies.
Flowchart for recruitment of study subjects according to the Standards for Reporting of Diagnostic Accuracy (STARD) studies.

FIGURE 2.

MRI and FDG-PET/CT imaging of two Hodgkin lymphoma (HL) patients. Left side (A, B): 12yo patient with newly diagnosed HL, (A) MRI examination with thoracal apparent diffusion coefficient (ADC) map. (B) correlating FDG-PET/CT examination with a HL lesion and calculated SUVmax. right side (C, D): 9yo patient with newly diagnosed HL, (C) MRI examination with neck ADC map. (D) correlating FDG-PET/CT examination with a HL lesion and calculated SUVmax.
MRI and FDG-PET/CT imaging of two Hodgkin lymphoma (HL) patients. Left side (A, B): 12yo patient with newly diagnosed HL, (A) MRI examination with thoracal apparent diffusion coefficient (ADC) map. (B) correlating FDG-PET/CT examination with a HL lesion and calculated SUVmax. right side (C, D): 9yo patient with newly diagnosed HL, (C) MRI examination with neck ADC map. (D) correlating FDG-PET/CT examination with a HL lesion and calculated SUVmax.

FIGURE 3.

Correlation of SUVmax and mean apparent diffusion coefficient (ADC). The calculated meanADC of the MRI examinations show a strong inverse correlation with the correlating SUVmax of the FDG-PET/CT examinations.
Correlation of SUVmax and mean apparent diffusion coefficient (ADC). The calculated meanADC of the MRI examinations show a strong inverse correlation with the correlating SUVmax of the FDG-PET/CT examinations.

FIGURE 4.

Neck imaging: correlation of SUVmax and mean apparent diffusion coefficient (ADC). The calculated meanADC of the MRI examinations show a strong inverse correlation with the correlating SUVmax of the FDG-PET/CT examinations.
Neck imaging: correlation of SUVmax and mean apparent diffusion coefficient (ADC). The calculated meanADC of the MRI examinations show a strong inverse correlation with the correlating SUVmax of the FDG-PET/CT examinations.

FIGURE 5.

Thoracal imaging: correlation of SUVmax and mean apparent diffusion coefficient (ADC). The calculated meanADC of the MRI examinations show a strong inverse correlation with the correlating SUVmax of the FDG-PET/CT examinations.
Thoracal imaging: correlation of SUVmax and mean apparent diffusion coefficient (ADC). The calculated meanADC of the MRI examinations show a strong inverse correlation with the correlating SUVmax of the FDG-PET/CT examinations.

FIGURE 6.

Abdominal imaging: correlation of SUVmax and meanADC. The calculated meanADC of the MRI examinations show a fair inverse correlation with the correlating SUVmax of the FDG-PET/CT examinations.
Abdominal imaging: correlation of SUVmax and meanADC. The calculated meanADC of the MRI examinations show a fair inverse correlation with the correlating SUVmax of the FDG-PET/CT examinations.

Magnetic resonance imaging sequences

SequenceOrientationBody part
T2w-TIRM in transversal orientationtransversalneck
T1w-TSE (fat suppressed, +/− contrast media)transversalneck
T1w-TSE (no fat suppression, with substraction, +/− contrast media)coronalneck
DWI (b-values: 50, 200, 800)transversalneck, body
T2w-HASTEcoronal, sagittal and transversalbody
T1w-VIBE (with fat suppression) without breath-hold-imaging +/− contrast mediatransversalbody

Patient characteristics and classifications

VariableRetrospective cohort of patients diagnosed with Hodgkin lymphoma; baseline features
No. of patients17
Median age (SD), years15.8 (2.2)
Sex
  Male11 (65%)
  Female6 (35%)
Lugano classification
  13 (18%)
  26 (35%)
  34 (23%)
  44 (23%)
Hodgkin lymphoma subtypes (WHO classification)
  Nodular sclerosis9 (52%)
  Mixed cellularity5 (29%)
  Lymphocyte rich2 (12%)
  Lymphocyte depleted1 (6%)

Radiation exposure and examination time

ModalityCTDI [mGy]DLP [mGy*cm]Examination time [min]
Mean (SD)RangeMean (SD)RangeMean (SD)Range
FDG-PET/CT2.2 (0.8)1.2–4.1215.1 (92.1)93.9–410.228 (8:26)120–49
MRI
  Neck 19:45 (3:41)17:21–24:47
  Thorax 09:23 (2:12)08:01–10:29
  Abdomen 09:23 (2:59)07:32–12:21
DOI: https://doi.org/10.2478/raon-2023-0021 | Journal eISSN: 1581-3207 | Journal ISSN: 1318-2099
Language: English
Page range: 150 - 157
Submitted on: Feb 2, 2023
Accepted on: Mar 27, 2023
Published on: Jun 21, 2023
Published by: Association of Radiology and Oncology
In partnership with: Paradigm Publishing Services
Publication frequency: 4 times per year

© 2023 Nicolas Rosbach, Sebastian Fischer, Vitali Koch, Thomas J. Vogl, Konrad Bochennek, Thomas Lehrnbecher, Scherwin Mahmoudi, Leon Grünewald, Frank Grünwald, Simon Bernatz, published by Association of Radiology and Oncology
This work is licensed under the Creative Commons Attribution 4.0 License.