References
- DeConde AS, Soler ZM. Chronic rhinosinusitis: epidemiology and burden of disease. Am J Rhinol Allergy 2016; 30: 134-9. 10.2500/ajra.2016.30.4297
- Snidvongs K, Lam M, Sacks R, Earls P, Kalish L, Phillips PS, et al. Structured histopathology profiling of chronic rhinosinusitis in routine practice. Int Forum Allergy Rhinol 2012; 2: 376-85. 10.1002/alr.21032
- Miljkovic D, Bassiouni A, Cooksley C, Ou J, Hauben E, Wormald PJ, et al. Association between Group 2 innate lymphoid cells enrichment, nasal polyps and allergy in chronic rhinosinusitis. Allergy 2014; 69: 1154-61. 10.1111/all.12440
- Wang X, Zhang N, Bo M, Holtappels G, Zheng M, Lou H, et al. Diversity of TH cytokine profiles in patients with chronic rhinosinusitis: a multicenter study in Europe, Asia, and Oceania. J Allergy Clin Immunol 2016; 138: 1344-53. 10.1016/j.jaci.2016.05.041
- Van Zele T, Claeys S, Gevaert P, Van Maele G, Holtappels G, Van Cauwenberge P, et al. Differentiation of chronic sinus diseases by measurement of inflammatory mediators. Allergy 2006; 61: 1280-9. 10.1111/j.1398-9995.2006.01225.x
- Van Bruaene N, Pérez-Novo CA, Basinski TM, Van Zele T, Holtappels G, De Ruyck N, et al. T-cell regulation in chronic paranasal sinus disease. J Allergy Clin Immunol 2008; 121: 1435-41.e3. 10.1016/j.jaci.2008.02.018
- Gevaert P, Van Bruaene N, Cattaert T, Van Steen K, Van Zele T, Acke F, et al. Mepolizumab, a humanized anti-IL-5 mAb, as a treatment option for severe nasal polyposis. J Allergy Clin Immunol 2011; 128: 989-95.e8. 10.1016/j.jaci.2011.07.056
- Soler ZM, Sauer D, Mace J, Smith TL. Impact of mucosal eosinophilia and nasal polyposis on quality-of-life outcomes after sinus surgery. Otolaryngol Head Neck Surg 2010; 142: 64-71. 10.1016/j.otohns.2009.10.005
- Tomassen P, Vandeplas G, Van Zele T, Cardell LO, Arebro J, Olze H, et al. Inflammatory endotypes of chronic rhinosinusitis based on cluster analysis of biomarkers. J Allergy Clin Immunol 2016; 137: 1449-56.e4. 10.1016/j.jaci.2015.12.1324
- Bachert C, Zhang N, Holtappels G, De Lobel L, van Cauwenberge P, Liu S, et al. Presence of IL-5 protein and IgE antibodies to staphylococcal enterotoxins in nasal polyps is associated with comorbid asthma. J Allergy Clin Immunol 2010; 126: 962-8.e6. 10.1016/j.jaci.2010.07.007
- Singhal D, Foreman A, Bardy JJ, Wormald PJ. Staphylococcus aureus biofilms. Laryngoscope 2011; 121: 1578-83. 10.1002/lary.21805
- Derycke L, Eyerich S, Van Crombruggen K, Pérez-Novo C, Holtappels G, Deruyck N, et al. Mixed T helper cell signatures in chronic rhinosinusitis with and without polyps. PLoS One 2014; 9: e97581. 10.1371/journal.pone.0097581
- Soklic TK, Silar M, Rijavec M, Koren A, Kern I, Hocevar-Boltezar I, et al. CD3 + CD4 - CD8 - mucosal T cells are associated with uncontrolled chronic rhinosinusitis with nasal polyps. J Allergy Clin Immunol 2019; 143: 1235-7.e5. 10.1016/j.jaci.2018.10.045
- Tan BK, Klingler AI, Poposki JA, Stevens WW, Peters AT, Suh LA, et al. Heterogeneous inflammatory patterns in chronic rhinosinusitis without nasal polyps in Chicago, Illinois. J Allergy Clin Immunol 2017; 139: 699-703. e7. 10.1016/j.jaci.2016.06.063
- Lam EPS, Kariyawasam HH, Rana BMJ, Durham SR, McKenzie ANJ, Powell N, et al. IL-25/IL-33-responsive TH2 cells characterize nasal polyps with a default TH17 signature in nasal mucosa. J Allergy Clin Immunol 2016; 137: 1514-24. 10.1016/j.jaci.2015.10.019
- Hulse KE, Stevens WW, Tan BK, Schleimer RP. Pathogenesis of nasal polyposis. Clin Exp Allergy 2015; 45: 328-46. 10.1111/cea.12472
- Akdis CA, Bachert C, Cingi C, Dykewicz MS, Hellings PW, Naclerio RM, et al. Endotypes and phenotypes of chronic rhinosinusitis: a PRACTALL document of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma & Immunology. J Allergy Clin Immunol 2013; 131: 1479-90. 10.1016/j.jaci.2013.02.036
- Krug N, Hohlfeld JM, Kirsten AM, Kornmann O, Beeh KM, Kappeler D, et al. Allergen-induced asthmatic responses modified by a GATA3-specific DNAzyme. N Engl J Med 2015; 372: 1987-95. 10.1056/NEJMoa1411776
- Livak KJ, Schmittgen TD. Analysis of relative gene expression data using realtime quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 2001; 25: 402-8. 10.1006/meth.2001.1262
- Seif F, Ghalehbaghi B, Aazami H, Mohebbi A, Ahmadi A, Falak R, et al. Frequency of CD4+ and CD8+ T cells in Iranian chronic rhinosinusitis patients. Allergy Asthma Clin Immunol 2018; 14: 47. 10.1186/s13223-018-0270-9
- Cao PP, Li HB, Wang BF, Wang SB, You XJ, Cui YH, et al. Distinct immunopathologic characteristics of various types of chronic rhinosinusitis in adult Chinese. J Allergy Clin Immunol 2009; 124: 478-84.e2. 10.1016/j.jaci.2009.05.017
- Szabo SJ, Kim ST, Costa GL, Zhang X, Fathman CG, Glimcher LH. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 2000; 100: 655-69.
- Fang D, Zhu J. Dynamic balance between master transcription factors determines the fates and functions of CD4 T cell and innate lymphoid cell subsets. J Exp Med 2017; 214: 1861-76. 10.1084/jem.20170494
- Iwata S, Mikami Y, Sun HW, Brooks SR, Jankovic D, Hirahara K, et al. The transcription factor T-bet limits amplification of type I IFN transcriptome and circuitry in T helper 1 cells. Immunity 2017; 46: 983-991.e4. 10.1016/j.immuni.2017.05.005
- Xin A, Masson F, Liao Y, Preston S, Guan T, Gloury R, et al. A molecular threshold for effector CD8+ T cell differentiation controlled by transcription factors Blimp-1 and T-bet. Nat Immunol 2016; 17: 422-32. 10.1038/ni.3410
- Greenough TC, Straubhaar JR, Kamga L, Weiss ER, Brody RM, McManus MM, et al. A gene expression signature that correlates with CD8 + T cell expansion in acute EBV infection. J Immunol 2015; 195: 4185-97. 10.4049/jimmunol.1401513
- Kurktschiev PD, Raziorrouh B, Schraut W, Backmund M, Wächtler M, Wendtner CM, et al. Dysfunctional CD8 + T cells in hepatitis B and C are characterized by a lack of antigen-specific T-bet induction. J Exp Med 2014; 211: 2047-59. 10.1084/jem.20131333
- Smith C, Elhassen D, Gras S, Wynn KK, Dasari V, Tellam J, et al. Endogenous antigen presentation impacts on T-box transcription factor expression and functional maturation of CD8+ T cells. Blood 2012; 120: 3237-45. 10.1182/blood-2012-03-420182
- Shin SH, Kim YH, Ye MK, Choi SY. Immunopathologic characteristics of nasal polyps in adult Koreans: A single-center study. Am J Rhinol Allergy 2017; 31: 168-73. 10.2500/ajra.2017.31.4423
- Zheng W, Flavell RA. The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell 1997; 89: 587-96.
- Wang L, Wildt KF, Zhu J, Zhang X, Feigenbaum L, Tessarollo L, et al. Distinct functions for the transcription factors GATA-3 and ThPOK during intrathymic differentiation of CD4(+) T cells. Nat Immunol 2008; 9: 1122-30. 10.1038/ni.1647
- Hoyler T, Klose CSN, Souabni A, Turqueti-Neves A, Pfeifer D, Rawlins EL, et al. The transcription factor GATA-3 controls cell fate and maintenance of type 2 innate lymphoid cells. Immunity 2012; 37: 634-48. 10.1016/j.immuni.2012.06.020
- Mjösberg J, Bernink J, Golebski K, Karrich JJ, Peters CP, Blom B, et al. The transcription factor GATA3 is essential for the function of human type 2 innate lymphoid cells. Immunity 2012; 37: 649-59. 10.1016/j.immuni.2012.08.015
- Crispin JC, Tsokos GC. Human TCR- + CD4- CD8- T cells can derive from CD8+ T cells and display an inflammatory effector phenotype. J Immunol 2009; 183: 4675-81. 10.4049/jimmunol.0901533
- Fischer K, Voelkl S, Heymann J, Przybylski GK, Mondal K, Laumer M, et al. Isolation and characterization of human antigen-specific TCRab+CD4- CD8-double-negative regulatory T cells. Blood 2005; 105: 2828-36. 10.1182/blood-2004-07-2583.Supported
- Zhang N, Van Zele T, Perez-Novo C, Van Bruaene N, Holtappels G, DeRuyck N, et al. Different types of T-effector cells orchestrate mucosal inflammation in chronic sinus disease. J Allergy Clin Immunol 2008; 122: 961-8. 10.1016/j.jaci.2008.07.008
- Wang Y, Misumi I, Gu AD, Curtis TA, Su L, Whitmire JK, et al. GATA-3 controls the maintenance and proliferation of T cells downstream of TCR and cytokine signaling. Nat Immunol 2013; 14: 714-22. 10.1038/ni.2623
- Lee N, You S, Shin MS, Lee WW, Kang KS, Kim SH, et al. IL-6 receptor α defines effector memory CD8 + T cells producing Th2 cytokines and expanding in asthma. Am J Respir Crit Care Med 2014; 190: 1383-94. 10.1164/rccm.201403-0601OC
- van Meijgaarden KE, Haks MC, Caccamo N, Dieli F, Ottenhoff THM, Joosten SA. Human CD8+ T-cells recognizing peptides from Mycobacterium tuberculosis (Mtb) presented by HLA-E have an unorthodox Th2-like, multifunctional, Mtb inhibitory phenotype and represent a novel human T-cell subset. PLoS Pathog 2015; 11: e1004671. 10.1371/journal.ppat.1004671
- Ivanov II, McKenzie BS, Zhou L, Tadokoro CE, Lepelley A, Lafaille JJ, et al. The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 2006; 126: 1121-33. 10.1016/j.cell.2006.07.035
- Spits H, Artis D, Colonna M, Diefenbach A, Di Santo JP, Eberl G, et al. Innate lymphoid cells – a proposal for uniform nomenclature. Nat Rev Immunol 2013; 13: 145-9. 10.1038/nri3365
- Kim YM, Munoz A, Hwang PH, Nadeau KC. Migration of regulatory T cells toward airway epithelial cells is impaired in chronic rhinosinusitis with nasal polyposis. Clin Immunol 2010; 137: 111-21. 10.1016/j.clim.2010.05.013
- Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003; 299: 1057-61. 10.1126/science.1079490
- Levine AG, Medoza A, Hemmers S, Moltedo B, Niec RE, Schizas M, et al. Stability and function of regulatory T cells expressing the transcription factor T-bet. Nature 2017; 546: 421-5. 10.1038/nature22360
- Wang Y, Su MA, Wan YY. An essential role of the transcription factor GATA-3 for the function of regulatory T cells. Immunity 2011; 35: 337-48. 10.1016/j.immuni.2011.08.012
- Kallies A, Good-Jacobson KL. Transcription factor T-bet orchestrates lineage development and function in the immune system. Trends Immunol 2017; 38: 287-97. 10.1016/j.it.2017.02.003
- Wang YH, Voo KS, Liu B, Chen CY, Uygungil B, Spoede W, et al. A novel subset of CD4 + TH2 memory/effector cells that produce inflammatory IL-17 cytokine and promote the exacerbation of chronic allergic asthma. J Exp Med 2010; 207: 2479-91. 10.1084/jem.20101376
- Peine M, Rausch S, Helmstetter C, Fröhlich A, Hegazy AN, Kühl AA, et al. Stable T-bet(+)GATA-3(+) Th1/Th2 hybrid cells arise in vivo, can develop directly from naive precursors, and limit immunopathologic iunflammation. PLoS Biol 2013; 11: e1001633. 10.1371/journal.pbio.1001633