Have a personal or library account? Click to login
Dendritic cell profiles in the inflamed colonic mucosa predict the responses to tumor necrosis factor alpha inhibitors in inflammatory bowel disease Cover

Dendritic cell profiles in the inflamed colonic mucosa predict the responses to tumor necrosis factor alpha inhibitors in inflammatory bowel disease

Open Access
|Nov 2018

References

  1. Geremia A, Biancheri P, Allan P, Corazza GR, Di Sabatino A. Innate and adaptive immunity in inflammatory bowel disease. Autoimmun Rev 2014; 13: 3-10. doi: 10.1016/j.autrev.2013.06.004
  2. Kmiec Z, Cyman M, Slebioda TJ. Cells of the innate and adaptive immunity and their interactions in inflammatory bowel disease. Adv Med Sci 2017; 62: 1-16. doi: 10.1016/j.advms.2016.09.001
  3. Niess JH. Role of mucosal dendritic cells in inflammatory bowel disease. World J Gastroenterol 2008; 14: 5138-48. doi: 10.3748/wjg.14.5138
  4. Rutella S, Locatelli F. Intestinal dendritic cells in the pathogenesis of inflammatory bowel disease. World J Gastroenterol 2011; 17: 3761-75. doi: 10.3748/wjg.v17.i33.3761
  5. Cader MZ, Kaser A. Recent advances in inflammatory bowel disease: mucosal immune cells in intestinal inflammation. Gut 2013; 62: 1653-64. doi: 10.1136/gutjnl-2012-303955
  6. Kushwah R, Hu J. Complexity of dendritic cell subsets and their function in the host immune system. Immunology 2011; 133: 409-19. doi: 10.1111/j.1365-2567.2011.03457.x
  7. Alloatti A, Kotsias F, Magalhaes JG, Amigorena S. Dendritic cell maturation and cross-presentation: timing matters! Immunol Rev 2016; 272: 97-108. doi: 10.1111/imr.12432
  8. Stockwin LH, McGonagle D, Martin IG, Blair GE. Dendritic cells: immunological sentinels with a central role in health and disease. Immunol Cell Biol 2000; 78: 91-102. doi: 10.1046/j.1440-1711.2000.00888.x
  9. Abbas A, Lichtman A, Pillai S. Basic immunology: functions and disorders of the immune system. 5th Edition. St. Louis, Missouri: Elsevier; 2015.
  10. Sallusto F, Lanzavecchia A. The instructive role of dendritic cells on T-cell responses. Arthritis Res 2002; 4: S127-32. doi: 10.1186/ar567
  11. Blanco P, Palucka AK, Pascual V, Banchereau J. Dendritic cells and cytokines in human inflammatory and autoimmune diseases. Cytokine Growth Factor Rev 2008; 19: 41-52. doi: 10.1016/j.cytogfr.2007.10.004
  12. Axelrad JE, Lichtiger S, Yajnik V. Inflammatory bowel disease and cancer: the role of inflammation, immunosuppression, and cancer treatment. World J Gastroenterol 2016; 22: 4794-801. doi: 10.3748/wjg.v22.i20.4794
  13. Coombes JL, Powrie F. Dendritic cells in intestinal immune regulation. Nat Rev Immunol 2008; 8: 435-46. doi: 10.1038/nri2335
  14. Choy MC, Visvanathan K, De Cruz P. An overview of the innate and adaptive immune system in inflammatory bowel disease. Inflamm Bowel Dis 2017; 23: 2-13. doi: 10.1097/mib.0000000000000955
  15. Persson EK, Scott CL, Mowat AM, Agace WW. Dendritic cell subsets in the intestinal lamina propria: ontogeny and function. Eur J Immunol 2013; 43: 3098-107. doi: 10.1002/eji.201343740
  16. Schiavi E, Smolinska S, O’Mahony L. Intestinal dendritic cells. Curr Opin Gastroenterol 2015; 31: 98-103. doi: 10.1097/mog.0000000000000155
  17. Vitale S, Strisciuglio C, Pisapia L, Miele E, Barba P, Vitale A, et al. Cytokine production profile in intestinal mucosa of paediatric inflammatory bowel disease. PLoS One 2017; 12: e0182313. doi: 10.1371/journal.pone.0182313
  18. Baumgart DC, Metzke D, Schmitz J, Scheffold A, Sturm A, Wiedenmann B, et al. Patients with active inflammatory bowel disease lack immature peripheral blood plasmacytoid and myeloid dendritic cells. Gut 2005; 54: 228-36. doi: 10.1136/gut.2004.040360
  19. Middel P, Raddatz D, Gunawan B, Haller F, Radzun HJ. Increased number of mature dendritic cells in Crohn’s disease: evidence for a chemokine mediated retention mechanism. Gut 2006; 55: 220-7. doi: 10.1136/ gut.2004.063008
  20. Baumgart DC, Metzke D, Guckelberger O, Pascher A, Grotzinger C, Przesdzing I, et al. Aberrant plasmacytoid dendritic cell distribution and function in patients with Crohn’s disease and ulcerative colitis. Clin Exp Immunol 2011; 166: 46-54. doi: 10.1111/j.1365-2249.2011.04439.x
  21. Sanchez-Munoz F, Dominguez-Lopez A, Yamamoto-Furusho JK. Role of cytokines in inflammatory bowel disease. World J Gastroenterol 2008; 14: 4280-8. doi: 10.3748/wjg.14.4280
  22. Van Deventer SJ. Tumour necrosis factor and Crohn’s disease. Gut 1997; 40: 443-8. doi: 10.1136/gut.40.4.443
  23. Sands BE, Kaplan GG. The role of TNFalpha in ulcerative colitis. J Clin Pharmacol 2007; 47: 930-41. doi: 10.1177/0091270007301623
  24. Levin AD, Wildenberg ME, van den Brink GR. Mechanism of action of anti-TNF therapy in inflammatory bowel disease. J Crohns Colitis 2016; 10: 989-97. doi: 10.1093/ecco-jcc/jjw053
  25. Nielsen OH, Ainsworth MA. Tumor necrosis factor inhibitors for inflammatory bowel disease. N Engl J Med 2013; 369: 754-62. doi: 10.1056/NEJMct1209614
  26. Chapman CG, Rubin DT. The potential for medical therapy to reduce the risk of colorectal cancer and optimize surveillance in inflammatory bowel disease. Gastrointest Endosc Clin N Am 2014; 24: 353-65. doi: 10.1016/j. giec.2014.03.008
  27. Andersen NN, Jess T. Has the risk of colorectal cancer in inflammatory bowel disease decreased? World J Gastroenterol 2013; 19: 7561-8. doi: 10.3748/wjg.v19.i43.7561
  28. Kopylov U, Seidman E. Predicting durable response or resistance to antitumor necrosis factor therapy in inflammatory bowel disease. Therap Adv Gastroenterol 2016; 9: 513-26. doi: 10.1177/1756283x16638833
  29. Gomollon F, Dignass A, Annese V, Tilg H, Van Assche G, Lindsay JO, et al. 3rd European evidence-based consensus on the diagnosis and management of Crohn’s disease 2016: part 1: diagnosis and medical management. J Crohns Colitis 2017; 11: 3-25. doi: 10.1093/ecco-jcc/jjw168
  30. Magro F, Gionchetti P, Eliakim R, Ardizzone S, Armuzzi A, Acosta MB, et al. Third european evidence-based consensus on diagnosis and management of ulcerative colitis. Part 1: definitions, diagnosis, extra-intestinal manifestations, pregnancy, cancer surveillance, surgery, and ileo-anal pouch disorders. J Crohns Colitis 2017; 11: 649-70. doi: 10.1093/ecco-jcc/jjx008
  31. Best WR. Predicting the Crohn’s disease activity index from the Harvey-Bradshaw Index. Inflamm Bowel Dis 2006; 12: 304-10. doi: 10.1097/01. MIB.0000215091.77492.2a
  32. Walmsley RS, Ayres RC, Pounder RE, Allan RN. A simple clinical colitis activity index. Gut 1998; 43: 29-32. doi: 10.1136/gut.43.1.29
  33. Daperno M, D’Haens G, Van Assche G, Baert F, Bulois P, Maunoury V, et al. Development and validation of a new, simplified endoscopic activity score for Crohn’s disease: the SES-CD. Gastrointest Endosc 2004; 60: 505-12. doi: 10.1016/S0016-5107(04)01878-4
  34. Buchner AM, Lichtenstein GR. How to assess and document endoscopies in IBD patients by including standard scoring systems. Inflamm Bowel Dis 2016; 22: 1010-9. doi: 10.1097/mib.0000000000000649
  35. Côté-Daigneault J, Bouin M, Lahaie R, Colombel JF, Poitras P. Biologics in inflammatory bowel disease: what are the data? United Eur Gastroenterol J 2015; 3: 419-28. doi: 10.1177/2050640615590302
  36. Scott CL, Wright PB, Milling SW, Mowat AM. Isolation and identification of conventional dendritic cell subsets from the intestine of mice and men. Methods Mol Biol 2016; 1423: 101-18. doi: 10.1007/978-1-4939-3606-9_7
  37. Roe MM, Swain S, Sebrell TA, Sewell MA, Collins MM, Perrino BA, et al. Differential regulation of CD103 (alphaE integrin) expression in human dendritic cells by retinoic acid and Toll-like receptor ligands. J Leukoc Biol 2017; 101: 1169-80. doi: 10.1189/jlb.1MA0316-131R
  38. Dige A, Magnusson MK, Ohman L, Hvas CL, Kelsen J, Wick MJ, et al. Reduced numbers of mucosal DR(int) macrophages and increased numbers of CD103(+) dendritic cells during anti-TNF-alpha treatment in patients with Crohn’s disease. Scand J Gastroenterol 2016; 51: 692-9. doi: 10.3109/00365521.2015.1134649
  39. Zampeli E, Gizis M, Siakavellas SI, Bamias G. Predictors of response to anti-tumor necrosis factor therapy in ulcerative colitis. World J Gastrointest Pathophysiol 2014; 5: 293-303. doi: 10.4291/wjgp.v5.i3.293
  40. Feagan BG, Sandborn WJ, Gasink C, Jacobstein D, Lang Y, Friedman JR, et al. Ustekinumab as induction and maintenance therapy for Crohn’s disease. N Engl J Med 2016; 375: 1946-60. doi: 10.1056/NEJMoa1602773
  41. McLean LP, Shea-Donohue T, Cross RK. Vedolizumab for the treatment of ulcerative colitis and Crohn’s disease. Immunotherapy 2012; 4: 883-98. doi: 10.2217/imt.12.85
  42. Colombel JF, Rutgeerts P, Reinisch W, Esser D, Wang Y, Lang Y, et al. Early mucosal healing with infliximab is associated with improved long-term clinical outcomes in ulcerative colitis. Gastroenterology 2011; 141: 1194-201. doi: 10.1053/j.gastro.2011.06.054
  43. Baert F, Moortgat L, Van Assche G, Caenepeel P, Vergauwe P, De Vos M, et al. Mucosal healing predicts sustained clinical remission in patients with early-stage Crohn’s disease. Gastroenterology 2010; 138: 463-8. doi: 10.1053/j. gastro.2009.09.056
  44. Magnusson MK, Brynjólfsson SF, Dige A, Uronen-Hansson H, Börjesson LG, Bengtsson JL, et al. Macrophage and dendritic cell subsets in IBD: ALDH(+) cells are reduced in colon tissue of patients with ulcerative colitis regardless of inflammation. Mucosal Immunol 2016; 9: 171-82. doi: 10.1038/mi.2015.48
  45. Annacker O, Coombes JL, Malmstrom V, Uhlig HH, Bourne T, Johansson-Lindbom B, et al. Essential role for CD103 in the T cell-mediated regulation of experimental colitis. J Exp Med 2005; 202: 1051-61. doi: 10.1084/jem.20040662
  46. Scott CL, Aumeunier AM, Mowat AM. Intestinal CD103+ dendritic cells: master regulators of tolerance? Trends Immunol 2011; 32: 412-9. doi: 10.1016/j.it.2011.06.003
  47. del Rio ML, Bernhardt G, Rodriguez-Barbosa JI, Forster R. Development and functional specialization of CD103+ dendritic cells. Immunol Rev 2010; 234: 268-81. doi: 10.1111/j.0105-2896.2009.00874.x
  48. Cerovic V, Houston SA, Scott CL, Aumeunier A, Yrlid U, Mowat AM, et al. Intestinal CD103(-) dendritic cells migrate in lymph and prime effector T cells. Mucosal Immunol 2013; 6: 104-13. doi: 10.1038/mi.2012.53
  49. Ruane DT, Lavelle EC. The role of CD103(+) dendritic cells in the intestinal mucosal immune system. Front Immunol 2011; 2: 25. doi: 10.3389/fimmu.2011.00025
  50. Iliev ID, Spadoni I, Mileti E, Matteoli G, Sonzogni A, Sampietro GM, et al. Human intestinal epithelial cells promote the differentiation of tolerogenic dendritic cells. Gut 2009; 58: 1481-9. doi: 10.1136/gut.2008.175166
  51. Annaházi A, Molnár T. Pathogenesis of ulcerative colitis and Crohn’s disease: similarities, differences and a lot of things we do not know yet. J Clin Cell Immunol 2014; 5: 253. doi: 10.4172/2155-9899.1000253
  52. Yarur AJ, Jain A, Sussman DA, Barkin JS, Quintero MA, Princen F, et al. The association of tissue anti-TNF drug levels with serological and endoscopic disease activity in inflammatory bowel disease: the ATLAS study. Gut 2016; 65: 249-55. doi: 10.1136/gutjnl-2014-308099
  53. Abraham C, Dulai PS, Vermeire S, Sandborn WJ. Lessons learned from trials targeting cytokine pathways in patients with inflammatory bowel diseases. Gastroenterology 2017; 152: 374-88. doi: 10.1053/j.gastro.2016.10.018
  54. Prieto-Perez R, Almoguera B, Cabaleiro T, Hakonarson H, Abad-Santos F. Association between genetic polymorphisms and response to anti-TNFs in patients with inflammatory bowel disease. Int J Mol Sci 2016; 17: 225. doi: 10.3390/ijms17020225
  55. Radwan P, Radwan-Kwiatek K, Tabarkiewicz J, Radej S, Rolinski J. Enhanced phenotypic and functional maturation of monocyte-derived dendritic cells from patients with active Crohn’s disease and ulcerative colitis. J Physiol Pharmacol 2010; 61: 695-703. PMID: 21224500
  56. Vuckovic S, Florin TH, Khalil D, Zhang MF, Patel K, Hamilton I, et al. CD40 and CD86 upregulation with divergent CMRF44 expression on blood dendritic cells in inflammatory bowel diseases. Am J Gastroenterol 2001; 96: 2946-56. doi: 10.1111/j.1572-0241.2001.04686.x
  57. Hart AL, Al-Hassi HO, Rigby RJ, Bell SJ, Emmanuel AV, Knight SC, et al. Characteristics of intestinal dendritic cells in inflammatory bowel diseases. Gastroenterology 2005; 129: 50-65. doi: 10.1053/j.gastro.2005.05.013
  58. Lombardi VC, Khaiboullina SF. Plasmacytoid dendritic cells of the gut: relevance to immunity and pathology. Clin Immunol 2014; 153: 165-77. doi: 10.1016/j.clim.2014.04.007
  59. Hostmann A, Kapp K, Beutner M, Ritz JP, Loddenkemper C, Ignatius R, et al. Dendritic cells from human mesenteric lymph nodes in inflammatory and non-inflammatory bowel diseases: subsets and function of plasmacytoid dendritic cells. Immunology 2013; 139: 100-8. doi: 10.1111/imm.12060
  60. Knight SC. Dendritic cell-T-cell circuitry in health and changes in inflammatory bowel disease and its treatment. Dig Dis 2016; 34: 51-7. doi: 10.1159/000442926
  61. Lagaraine C, Lebranchu Y. Effects of immunosuppressive drugs on dendritic cells and tolerance induction. Transplantation 2003; 75: 37s-42s. doi: 10.1097/01.tp.0000067950.90241.1d
  62. Teig N, Moses D, Gieseler S, Schauer U. Age-related changes in human blood dendritic cell subpopulations. Scand J Immunol 2002; 55: 453-7. doi: 10.1046/j.1365-3083.2002.01068.x
  63. Bella SD, Bierti L, Presicce P, Arienti R, Valenti M, Saresella M, et al. Peripheral blood dendritic cells and monocytes are differently regulated in the elderly. Clin Immunol 2007; 122: 220-8. doi: 10.1016/j.clim.2006.09.012
  64. Dzutsev A, Hogg A, Sui Y, Solaymani-Mohammadi S, Yu H, Frey B, et al. Differential T cell homing to colon vs. small intestine is imprinted by local CD11c(+) APCs that determine homing receptors. J Leukoc Biol 2017; 102: 1381-8. doi: 10.1189/jlb.1A1116-463RR
  65. Cleynen I, Boucher G, Jostins L, Schumm LP, Zeissig S, Ahmad T, et al. Inherited determinants of Crohn’s disease and ulcerative colitis phenotypes: a genetic association study. Lancet 2016; 387: 156-67. doi: 10.1016/s0140-6736(15)00465-1
DOI: https://doi.org/10.2478/raon-2018-0045 | Journal eISSN: 1581-3207 | Journal ISSN: 1318-2099
Language: English
Page range: 443 - 452
Submitted on: Sep 12, 2018
|
Accepted on: Oct 25, 2018
|
Published on: Nov 26, 2018
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2018 Natasa Smrekar, David Drobne, Lojze M. Smid, Ivan Ferkolj, Borut Stabuc, Alojz Ihan, Andreja Natasa Kopitar, published by Association of Radiology and Oncology
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.