Perfusion magnetic resonance imaging changes in normal appearing brain tissue after radiotherapy in glioblastoma patients may confound longitudinal evaluation of treatment response

Figure 1

Figure 2

Figure 3

Mean, standard error of mean (SEM) and change relative pre-fractionated radiotherapy (pre-FRT) for global nCBV and nCBF_ Global normalised cerebral blood volume (nCBV) and normalised cerebral blood flow (nCBF) (mean and SEM), change in percentage relative pre-FRT (mean and SD) and derived P-values from a Wilcoxson matched-pair signed ranks test comparing post-FRT data with pre-FRT data_ Corresponding table for regional nCBV and nCBF can be found in S2 Table

nCBVWMGM $\begin{array}{} \displaystyle \rm nCBV^{GM}_{WM} \end{array}$
	Pre-FRT	FRTPost-1	FRTPost-2	FRTPost-3
ΔCBV	1.63±0.03	1.53±0.04	1.49±0.05	1.53±0.03
ΔnCBV (%)		-6.7±7.7	-4.6±11.7	-6.0±9.3
p-value		<0,0001	0,0535	<0,0001
nCBFWMGM $\begin{array}{} \displaystyle \rm nCBF^{GM}_{WM} \end{array}$
	Pre-FRT	FRTPost-1	FRTPost-2	FRTPost-3
nCBF	1.60±0.03	1.53±0.03	1.37±0.04	1.46±0.03
ΔnCBF (%)		-5.1±11.7	-12.5±11.4	-7.5±8.2
p-value		0,0057	<0,0001	<0,0001
nCBVWMWM $\begin{array}{} \displaystyle \rm nCBV^{WM}_{WM} \end{array}$
	Pre-FRT	FRTPost-1	FRTPost-2	FRTPost-3
nCBV	1.10±0.03	1.06±0.03	1.03±0.03	1.05±0.03
ΔnCBV (%)		-4.3±7.6	0.7±11.7	-3.6±11.9
p-value		0,0003	0,3818	0,1197
nCBFWMWM $\begin{array}{} \displaystyle \rm nCBF^{WM}_{WM} \end{array}$
	Pre-FRT	FRTPost-1	FRTPost-2	FRTPost-3
nCBF	1.09±0.02	1.08±0.03	0.96±0.03	1.05±0.03
ΔnCBF (%)		-3.1±7.7	-7.4±10.5	-3.4±10.3
p-value		0,0166	0,0002	0,2267
nCBVGMGM $\begin{array}{} \displaystyle \rm nCBV^{GM}_{GM} \end{array}$
	Pre-FRT	FRTPost-1	FRTPost-2	FRTPost-3
nCBV	1.00±0.01	0.99±0.01	1.02±0.02	1.0±0.02
ΔnCBV (%)		-0.9±4.0	1.7±5.7	-0.4±6.8
p-value		0,1629	0,184	0,6445
nCBFGMGM $\begin{array}{} \displaystyle \rm nCBF^{GM}_{GM} \end{array}$ $
	Pre-FRT	FRTPost-1	FRTPost-2	FRTPost-3
nCBF	1.02±0.01	1.01±0.01	1.00±0.01	1.02±0.01
ΔnCBF (%)		-0.1±5.1	-2.8±4.7	0.0±4.5
p-value		0,4922	0,0073	0,9252