Figure 1
Dose region distribution with corresponding pre-fractionated radiotherapy (pre-FRT) Gd-T1w image. Representative dose region distribution with corresponding pre-FRT GD-T1w image for one patient. Dose distribution was divided into seven binary regions (0–5 Gy, 5–10 Gy, 10–20 Gy, 20–30 Gy, 30–40 Gy, 40–50 Gy and 50–60 Gy). Resection cavity, post-FRT effects and tumour tissue were excluded.
Figure 2
Longitudinal change in global normalised cerebral blood volume (nCBV) and normalised cerebral blood flow (nCBF). Global nCBV and nCBF (mean and 95% CI) graphically displayed for the different examinations in consecutive order. Derived P-values are included, and emphasised in bold and italics if less than 0.05. Corresponding table for regional nCBV and nCBF can be found in S1 and S2 Figures.
Table 1
Mean, standard error of mean (SEM) and change relative pre-fractionated radiotherapy (pre-FRT) for global nCBV and nCBF. Global normalised cerebral blood volume (nCBV) and normalised cerebral blood flow (nCBF) (mean and SEM), change in percentage relative pre-FRT (mean and SD) and derived P-values from a Wilcoxson matched-pair signed ranks test comparing post-FRT data with pre-FRT data. Corresponding table for regional nCBV and nCBF can be found in S2 Table
| Pre-FRT | FRTPost-1 | FRTPost-2 | FRTPost-3 | |
| ΔCBV | 1.63±0.03 | 1.53±0.04 | 1.49±0.05 | 1.53±0.03 |
| ΔnCBV (%) | -6.7±7.7 | -4.6±11.7 | -6.0±9.3 | |
| p-value | <0,0001 | 0,0535 | <0,0001 | |
| Pre-FRT | FRTPost-1 | FRTPost-2 | FRTPost-3 | |
| nCBF | 1.60±0.03 | 1.53±0.03 | 1.37±0.04 | 1.46±0.03 |
| ΔnCBF (%) | -5.1±11.7 | -12.5±11.4 | -7.5±8.2 | |
| p-value | 0,0057 | <0,0001 | <0,0001 | |
| Pre-FRT | FRTPost-1 | FRTPost-2 | FRTPost-3 | |
| nCBV | 1.10±0.03 | 1.06±0.03 | 1.03±0.03 | 1.05±0.03 |
| ΔnCBV (%) | -4.3±7.6 | 0.7±11.7 | -3.6±11.9 | |
| p-value | 0,0003 | 0,3818 | 0,1197 | |
| Pre-FRT | FRTPost-1 | FRTPost-2 | FRTPost-3 | |
| nCBF | 1.09±0.02 | 1.08±0.03 | 0.96±0.03 | 1.05±0.03 |
| ΔnCBF (%) | -3.1±7.7 | -7.4±10.5 | -3.4±10.3 | |
| p-value | 0,0166 | 0,0002 | 0,2267 | |
| Pre-FRT | FRTPost-1 | FRTPost-2 | FRTPost-3 | |
| nCBV | 1.00±0.01 | 0.99±0.01 | 1.02±0.02 | 1.0±0.02 |
| ΔnCBV (%) | -0.9±4.0 | 1.7±5.7 | -0.4±6.8 | |
| p-value | 0,1629 | 0,184 | 0,6445 | |
| Pre-FRT | FRTPost-1 | FRTPost-2 | FRTPost-3 | |
| nCBF | 1.02±0.01 | 1.01±0.01 | 1.00±0.01 | 1.02±0.01 |
| ΔnCBF (%) | -0.1±5.1 | -2.8±4.7 | 0.0±4.5 | |
| p-value | 0,4922 | 0,0073 | 0,9252 | |
Figure 3
Dose-dependent relative change and linear regression model for normalised cerebral blood volume (nCBV). Shows regional relative change for nCBV and derived line regression (line and equation).
Corresponding figure for normalised cerebral blood flow (nCBF) can be found in S3 Figure.