Association of sputum and peripheral blood eosinophils with clinical severity in bronchial asthma
By: Akhila Chitteddi, Georgin Shaji and Sai Sindhu Kaza
References
- Bandyopadhyay A, Roy PP, Saha K, Chakraborty S, Jash D, Saha D. Usefulness of induced sputum eosinophil count to assess severity and treatment outcome in asthma. Lung India. 2013;30(2): 117–123. doi:10.4103/0970-2113.110419
- Global Initiative for Asthma (GINA). Global strategy for asthma management and prevention. (2015) Available from: https://gin-asthma.org/
- Kumar RM, Pajanivel R, Koteswaran G, Menon SK, Charles MV. Correlation of total serum IgE, sputum and peripheral eosinophil count in assessing clinical severity in bronchial asthma. Lung India. 2017;34: 256–261. doi:10.4103/lungindia. lungindia_73_16
- Nakagome K, Nagata M. Involvement, and possible role of eosinophils in asthma exacerbation. Frontiers in Immunology. 2018;9: 2220. doi:10.3389/fimmu.2018.02220
- Zeiger RS, Schatz M, Li Q, Chen W, Khatry DB, Gossage D, et al. High blood eosinophil count as a risk factor for future asthma exacerbations. The Journal of Allergy and Clinical Immunology in Practice. 2014;2(6): 741–750. doi:10.1016/j. jaip.2014.06.005
- Wagener AH, de Nijs SB, Lutter R, Sousa AR, Weersink EJ, Bel EH, Sterk PJ. External validation of blood eosinophils, FeNO and serum periostea as surrogates for sputum eosinophils in asthma. Thorax. 2015;70(2): 115–120. doi:10.1136/thoraxjnl-2014-205634
- Sposato B, Latorre M, Scalese M, Bradicich M, Brighindi S, Del Cesta MDR, et al. Blood vs sputum eosinophils as predictors of exacerbations in severe asthma. European Respiratory Journal. 2018;52: A950. doi:10.1183/13993003.congress-2018.PA950
- Spahn JD. Asthma biomarkers in sputum. Immunology and Allergy Clinics of North America. 2012;32(3): 387–399. doi:10.1016/j.iac.2012.06.004
- Fujimoto K, Kubo K, Matsuzawa Y, Sekiguchi M. Eosinophil cationic protein levels in induced sputum correlate with asthma severity. Chest. 1997;112: 1241–1247. doi:10.1378/chest.112.5.1241
- Ronchi MC, Piragino C, Rosi E, Stendardi L, Tanini A, Galli G, et al. Relationship of sputum eosinophils and ECP to asthma severity. European Respiratory Journal. 1997;10: 1809–1813. doi: 10.1183/09031936.97.10081809
- Duncan CJ, Lawrie A, Blaylock MG, Douglas JG, Walsh GM. Reduced eosinophil apoptosis in induced sputum correlates with asthma severity. European Respiratory Journal. 2003;22: 484–490. doi:10.1183/09031936.03.00109803a
- Johansson M. Activation states of blood eosinophils in asthma. Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology. 2014;44(4): 482–498. doi:10.1111/cea.12292
- Bedolla-Barajas M, Ortiz-Peregrina JR, Hernández-Colin D, Morales-Romero J, Ramses Bedolla-Pulido T, Larenas-Linnemann D. Characterization of asthma with blood eosinophilia in adults. The Journal of Asthma: Official Journal of the Association for the Care of Asthma. 2019;56(11): 1138–1146. doi:10.1080/02770903.2018.1520863
- Shi B, Li W, Hao Y, et al. Blood count parameters and sputum inflammatory phenotypes in asthma. Allergy, Asthma, and Clinical Immunology. 2021;17: 47. doi:10.1186/s13223-021-00548-z
- Gao J, Wu F. Association between FeNO, sputum induction, and blood eosinophils in uncontrolled asthma. Allergy, Asthma, and Clinical Immunology. 2018;14: 21. doi:10.1186/s13223-018-0248-7
- Demarche SF, Schleich FN, Paulus VA, Henket MA, Van Hees TJ, Louis RE. Accuracy of biomarkers in predicting sputum eosinophils ≥3%. Respiratory Research. 2017;18: 133. doi:10.1186/s12931-017-0615-9
- Li JH, Han R, Wang YB, et al. Diagnostic value of FeNO combined with blood eosinophils. BMC Pulmonary Medicine. 2021;21: 259. doi:10.1186/s12890-021-01626-z
- Meteran H, Sivapalan P, Jensen JS. Treatment response biomarkers in asthma and COPD. Diagnostics (Basel). 2021;11: 1668. doi:10.3390/diagnostics11091668
- Hussain M, Liu G. Eosinophilic asthma: pathophysiology and therapeutic horizons. Cells. 2024;13: 384. doi:10.3390/cells13050384
Language: English
Page range: 14 - 19
Published on: Mar 30, 2026
Published by: Romanian Society of Pneumology
In partnership with: Paradigm Publishing Services
Publication frequency: Volume open
Related subjects:
© 2026 Akhila Chitteddi, Georgin Shaji, Sai Sindhu Kaza, published by Romanian Society of Pneumology
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.