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Association between hypoalbuminemia and pulmonary CT severity in COVID-19 ICU patients: A cohort study Cover

Association between hypoalbuminemia and pulmonary CT severity in COVID-19 ICU patients: A cohort study

Open Access
|Feb 2026

References

  1. Brosnahan SB, Jonkman AH, Kugler MC, Munger JS, Kaufman DA. COVID-19 and respiratory system disorders: current knowledge, future clinical and translational research questions. Arteriosclerosis, Thrombosis, and Vascular Biology. 2020;40(11): 2586-2597. doi:10.1161/ATVBAHA.120.314515
  2. Rezaeetalab F, Mozdourian M, Amini M, Javidarabshahi Z, Akbari F. COVID-19: a new virus as a potential rapidly spreading in the worldwide. Journal of Cardio-Thoracic Medicine. 2020;8(1): 563-564.
  3. Paules CI, Marston HD, Fauci AS. Coronavirus infections-more than just the common cold. JAMA. 2020;323(8): 707-708. doi:10.1001/jama.2020.0757
  4. Acharya R, Poudel D, Bowers R, Patel A, Schultz E, Bourgeois M, et al. Low serum albumin predicts severe outcomes in COVID-19 infection: a single-center retrospective case-control study. Journal of Clinical Medicine Research. 2021 ;13(5): 258-267. doi:10.14740/jocmr4507
  5. Viana-Llamas MC, Arroyo-Espliguero R, Silva-Obregón JA, Uribe-Heredia G, Núñez-Gil I, García-Magallón B, et al. Hypoalbuminemia on admission in COVID-19 infection: an early predictor of mortality and adverse events. A retrospective observational study. Medicina Clínica (Barc). 2021;156(9): 428-436. doi:10.1016/j.medcli.2020.12.018
  6. Violi F, Cangemi R, Romiti GF, Ceccarelli G, Oliva A, Alessandri F, et al. Is albumin predictor of mortality in COVID-19? Antioxidants & Redox Signaling. 2021;35(2): 139-142. doi:10.1089/ars.2020.8142
  7. Xu Y, Yang H, Wang J, Li X, Xue C, Niu C, et al. Serum albumin levels are a predictor of COVID-19 patient prognosis: evidence from a single cohort in Chongqing, China. International Journal of General Medicine. 2021;14: 2785-2797. doi:10.2147/IJGM. S312521
  8. Huang J, Cheng A, Kumar R, Fang Y, Chen G, Zhu Y, et al. Hypoalbuminemia predicts the outcome of COVID-19 independent of age and co-morbidity. Journal of Medical Virology. 2020;92(10): 2152-2158. doi:10.1002/jmv.26003
  9. Huang W, Li C, Wang Z, Wang H, Zhou N, Jiang J, et al. Decreased serum albumin level indicates poor prognosis of COVID-19 patients: hepatic injury analysis from 2,623 hospitalized cases. Science China Life Sciences. 2020;63(11): 1678-1687. doi:10.1007/s11427-020-1733-4
  10. Abdeen Y, Kaako A, Ahmad Amin Z, Muhanna A, Josef¡ne Froessl L, Alnabulsi M, Okeh A, Miller RA. The Prognostic Effect of Serum Albumin Level on Outcomes of Hospitalized COVID-19 Patients. Crit Care Res Pract. 2021 Jun 9; doi: 10.1155/2021/9963274.
  11. Ruch Y, Kaeuffer C, Ohana M, Labani A, Fabacher T, Bilbault P, et al. CT lung lesions as predictors of early death or ICU admission in COVID-19 patients. Clinical Microbiology and Infection: the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases. 2020;26(10): 1417. e5-.e8. doi:10.1016/j.cmi.2020.07.030
  12. Gatta A, Verardo A, Bolognesi M. Hypoalbuminemia. Internal and Emergency Medicine. 2012;7(Suppl 3): S193-199. doi:10.1007/s11739-012-0802-0
  13. Bwire GM. Coronavirus: why men are more vulnerable to COVID-19 than women? SN Comprehensive Clinical Medicine. 2020;2(7): 874-876. doi:10.1007/s42399-020-00341-w
  14. Johnson AS, Winlow W. COVID-19 vulnerabilities are intensitied by declining human serum albumin levels. Experimental Physiology. 2022;107(7): 674-682. doi:10.1113/EP089703
  15. Baig MA, Raza MM, Baig M, Baig MU. Serum albumin levels monitoring in ICU in early days and mortality risk association in patients with moderate to severe COVID-19 pneumonia. Pakistan Journal of Medical Sciences. 2022;38(3 Part-I): 612-616. doi:10.12669/pjms.38.3.4154
  16. Kowsar R, Rahimi AM, Sroka M, Mansouri A, Sadeghi K, Bonakdar E, et al. Risk of mortality in COVID-19 patients: a meta and network analysis. Scientific Reports. 2023;13(1): 2138. doi:10.1038/s41598-023-29364-8
  17. Li J, Li M, Zheng S, Li M, Zhang M, Sun M, et al. Plasma albumin levels predict risk for nonsurvivors in critically ill patients with COVID-19. Biomarkers in Medicine. 2020;14(10): 827-837. doi:10.2217/bmm-2020-0254
  18. Uyar E, Merdin A, Yamanyar S, Ezgü MC, Artuk C, Taşkin G, et al. Could serum albumin value and thrombocyte/lymphocyte ratio be an important prognostic factor in determining the severity of COVID 19? Turkish Journal of Medical Sciences. 2021;51(3): 939-946. doi:10.3906/sag-2008-285
DOI: https://doi.org/10.2478/pneum-2025-0039 | Journal eISSN: 2247-059X | Journal ISSN: 2067-2993
Language: English
Page range: 143 - 148
Published on: Feb 19, 2026
In partnership with: Paradigm Publishing Services
Publication frequency: Volume open

© 2026 Farzaneh Akbari, Mohammad Ami Jaberi Mofradn, Fariba Rezaeetalab, Elham Shaarbaf Eidgah, published by Romanian Society of Pneumology
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.