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Association between hypoalbuminemia and pulmonary CT severity in COVID-19 ICU patients: A cohort study Cover

Association between hypoalbuminemia and pulmonary CT severity in COVID-19 ICU patients: A cohort study

Open Access
|Feb 2026

Figures & Tables

Logistic regression results_

Unadjusted logistic regressionAdjusted logistic regression
VariablesCoefficientORP-valueVariablesCoefficientOR95% CIP-value
Gender (male)–0.270.770.475Age (years)0.011.01(0.99, 1.04)0.262
Age (years)0.021.020.060Hypertension0.531.69(0.76, 3.79)0.198
Diabetes0.090.950.794Albumin–0.920.39(0.18, 0.90)0.027
COPD0.291.100.615
IHD0.391.480.361
Hypertension0.621.860.103
Intubation–0.310.890.632
Albumin–0.950.390.020
CT score0.001.000.998
CRP0.0021.0020.481

Vital signs and laboratory findings

Variable parametersMean ± SDMin–Max
Systolic blood pressure (mmHg)129.79 ± 22.0790–250
Diastolic blood pressure (mmHg)79.69 ± 12.3358–30
Heart rate (per min)99.23 ± 19.4952–;158
Respiratory rate (per min)20.08 ± 3.8914–45
Laboratory findings
Albumin (g/dL)3.13 ± 0.491.80–4.40
CRP (mg/dL)127.02 ± 83.880.50–395
BUN (mg/dL)45.33 ± 20.369–120
Creatinine (mg/dL)0.99 ± 0.250.30–1.90
AST (u/L)46.40 ± 22.698–174
ALT (μ/L)37.16 ± 24.656–;134
ALP (μ/L)206.31 ± 95.6429–657
WBC (109/L10.43 ± 7.230.8–75
Haemoglobin (g/dL)13.10 ± 2.225.50–19.50
Platelets214.09 ± 89.543–486
Lymphocytes (%)11.74 ± 6.910.80–40.80

Comparison of TSS and serum albumin_

ParametersHypoalbuminemiaNormal serum albumin95% CI for the differenceP-valueCohen’s p
TSS on first CT scan (mean ± SD)13.42 ± 5.2411.71 ± 6.68(–4.13,0.72)0.163–0.31

Comparison of TSS levels among degrees of hypoalbuminemia_

HypoalbuminemiaNormal Serum albumin (n=36)P-valueEta squared
Severe(n=3)Moderate(n=71)Mild (n=86)
TSS on first CT scan15.67 ± 1.5313.08 ± 5.7613.62 ± 4.8515.67 ± 1.530.3120.02
Comparison betweenAliveExpired (n = 3)Alive (n = 6)Expired (n = 65)Alive (n = 21)Expired (n = 65)Alive (n = 10)Expired (n = 26)
TSS on first CT scan15.67 ± 1.5316.83 ± 2.3212.74 ± 5.8712.29 ± 5.5614.05 ± 4.5712.56 ± 4.9811.42 ± 7.23
P-value 0.005 0.150 0.609
Eta squared 0.720 –0.365 0168

Comparison of serum albumin levels in survivors and non-survivors_

ParametersSurvivors (mean ± SD)Non-survivors (mean ± SD)95% CI for the difference between survivors and non-survivorsP-valueCohen’s d
First albumin (g/dL)3.30 ± 0.353.09 ± 0.51(0.07, 0.35)0.0030.43
Second albumin (g/dL)3.17 ± 0.412.81 ± 0.53(0.11,0.77)0.0060.72
TSS on first CT13.20 ± 5.2413.11 ± 5.63(-1.96, 0.63)0.9340.02
DOI: https://doi.org/10.2478/pneum-2025-0039 | Journal eISSN: 2247-059X | Journal ISSN: 2067-2993
Language: English
Page range: 143 - 148
Published on: Feb 19, 2026
In partnership with: Paradigm Publishing Services
Publication frequency: Volume open

© 2026 Farzaneh Akbari, Mohammad Ami Jaberi Mofradn, Fariba Rezaeetalab, Elham Shaarbaf Eidgah, published by Romanian Society of Pneumology
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.