Bronchiectasis: The hidden side of common variable immunodeficiency – Case report

(1) immunoglobulin (Ig) G level less than SD below age-appropriate references for 2 measurements more than 3weeks apart unless the level is very low (<100-300 mg/dL depending on age);

(2) no secondary causes of hypogammaglobulinemia.

(3) poor antibody responses to vaccination;

(4) greater than 4 years of age;

(5) either a low IgA or IgM;

(1) decrease of IgA is required;

(2) low switched memory B cells (less than 70% of age-related normal value) can be used instead of measurement of antibody response to vaccine;

(3) no evidence of profound T cell deficiency;

(4) a clinical manifestation of disease such as an increased susceptibility to infection, autoimmune manifestations, granulomatous disease, or unexplained polyclonal lymphoproliferation, or an affected family member with antibody deficiency