Analysis of 177Lu-DOTATATE injection methods and their impact on the exposure of hands of nuclear medicine facility staff
References
- Nowotwory neuroendokrynne coraz częstsze. MZdrowie [Internet]. Available from: https://www.mzdrowie.pl/medycyna/nowotwory-neuroendokrynne-coraz-czestsze/. Accessed October 20, 2025.
- Stokke C, Kvassheim M, Blakkisrud J. Radionuclides for Targeted Therapy: Physical Properties. Molecules. 2022;27(17):5429. https://doi.org/10.3390/molecules27175429
- Strosberg J, El-Haddad G, Wolin E, et al. Phase 3 Trial of 177Lu-Dotatate for Midgut Neuroendocrine Tumors. N Engl J Med. 2017;376(2):125-135. https://doi.org/10.1056/nejmoa1607427
- Bodei L, Cremonesi M, Ferrari M, et al. Dosimetry of [177Lu]Lu-DOTATATE in Patients with Advanced Midgut Neuroendocrine Tumors: Results from a Substudy of the Phase III NETTER-1 Trial. J Nucl Med. 2025;66(3):449-456. https://doi.org/10.2967/jnumed.124.268903
- Demirci E, Kabasakal L, Toklu T, et al. 177Lu-DOTATATE therapy in patients with neuroendocrine tumours including high-grade (WHO G3) neuroendocrine tumours. Nuclear Medicine Communications. 2018;39(8):789-796. https://doi.org/10.1097/mnm.0000000000000874
- International Commission on Radiation Units and Measurements. Radiation Dosimetry: X Rays Generated at Energies Below 50 keV. ICRU Report 35. Bethesda, MD: ICRU; 1984.
- International Commission on Radiation Units and Measurements. Photon, Electron, Proton and Neutron Interaction Data for Body Tissues. ICRU Report 46. Bethesda, MD: ICRU; 1992.
- Berger MJ, Hubbell JH, Seltzer SM, et al. XCOM: Photon Cross Section Database (version 1.5) [Internet]. NIST; 2010. Available from: https://physicist.nist.gov/xcom
- Davis AB, Pietryka MH, Passalaqua S. Technical Aspects and Administration Methods of 177Lu-DOTATATE for Nuclear Medicine Technologists. J Nucl Med Technol. 2019;47(4):288-291. https://doi.org/10.2967/jnmt.118.221846
- Donzé C, Rubira L, Santoro L, et al. 177Lu-Dotatate administration using an infusion pump or a peristaltic pump: comparison of two methods. Eur J Hosp Pharm. 2022;31(3):207-211. https://doi.org/10.1136/ejhpharm-2022-003489
- Dash A, Pillai MRA, Knapp FF Jr. Production of 177Lu for Targeted Radionuclide Therapy: Available Options. Nucl Med Mol Imaging. 2015;49(2):85-107. https://doi.org/10.1007/s13139-014-0315-z
- European Commission. Summary of Product Characteristics - Lutathera® [Internet]. 2022. Available from: https://ec.europa.eu/health/documents/community-register/2022/20220708156050/anx_156050_pl.pdf
- Hirning CR. Detection and Determination Limits For Thermoluminescence Dosimetry. Health Physics. 1992;62(3):223-227. https://doi.org/10.1097/00004032-199203000-00002
- Hope TA, Abbott A, Colucci K, et al. NANETS/SNMMI Procedure Standard for Somatostatin Receptor–Based Peptide Receptor Radionuclide Therapy with 177Lu-DOTATATE. J Nucl Med. 2019;60(7):937-943. https://doi.org/10.2967/jnumed.118.230607
- Abbott A, Sakellis CG, Andersen E, et al. Guidance on 177Lu-DOTATATE Peptide Receptor Radionuclide Therapy from the Experience of a Single Nuclear Medicine Division. J Nucl Med Technol. 2018;46(3):237-244. https://doi.org/10.2967/jnmt.118.209148
- Riveira-Martin M, Struelens L, Muñoz Iglesias J, et al. Radiation exposure assessment of nuclear medicine staff administering [177Lu]Lu-DOTA-TATE with active and passive dosimetry. EJNMMI Phys. 2023;10(1). https://doi.org/10.1186/s40658-023-00592-1
- Struelens L, Aalbersberg E, Beels L, et al. How much do 68Ga-, 177Lu- and 131I-based radiopharmaceuticals contribute to the global radiation exposure of nuclear medicine staff? EJNMMI Phys. 2024;11(1). https://doi.org/10.1186/s40658-024-00695-3
DOI: https://doi.org/10.2478/pjmpe-2026-0015 | Journal eISSN: 1898-0309 (formerly 1425-4689) | Journal ISSN: 1425-4689
Language: English
Page range: 138 - 145
Submitted on: Feb 3, 2026
Accepted on: Aug 6, 2026
Published online: Sep 30, 2026
Published in print: Sep 1, 2026
Published by: Polish Society of Medical Physics
In partnership with: Paradigm Publishing Services
Keywords:
Related subjects:
© 2026 Łukasz Albiniak, Hanna Piwowarska-Bilska, Marta Rowińska, Bożena Birkenfeld, Małgorzata Wrzesień, published by Polish Society of Medical Physics
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.