Synthesis and characterization of curcumin-encapsulated loaded on carboxymethyl cellulose with docking validation as α-amylase and α-glucosidase inhibitors

Abdulrahman A. Almehizia; Mohamed A. Al-Omar; Abdulrahman M. Al-Obaid; Ahmed M. Naglah; Mashooq A. Bhat; Hazem A. Ghabbour; Tamer K. Khatab; Ashraf S. Hassan

doi:10.2478/pjct-2024-0031

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Synthesis and characterization of curcumin-encapsulated loaded on carboxymethyl cellulose with docking validation as α-amylase and α-glucosidase inhibitors

Green Sciences

Volume 26 (2024): Issue 3 (September 2024)

By: Abdulrahman A. Almehizia, Mohamed A. Al-Omar, Abdulrahman M. Al-Obaid, Ahmed M. Naglah, Mashooq A. Bhat, Hazem A. Ghabbour, Tamer K. Khatab and Ashraf S. Hassan

Open Access

|Sep 2024

Abstract

In reaction to the expanding predominance of diabetes mellitus, curcumin nanoparticles stacked on carboxymethyl cellulose (CMC) composite were effectively synthesized, characterized, and examined utilizing UV/Vis and FTIR spectroscopy combined with transmission electron microscopy (TEM). The bioactivity of curcumin (Cur), carboxymethyl cellulose (CMC), and curcumin nanoparticles stacked with carboxymethyl cellulose (CUR-CMC) was tried through atomic docking approval as an α-amylase and α-glucosidase inhibitor. The conclusion illustrated that the curcumin-supported CMC is more potent than CUR itself self the validation presented is compared with acarbose as a reference molecule and then CUR-CMC can presented as promising in curing hyperglycemia by decreasing the absorption of glucose.

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Articles in this issue

DOI: https://doi.org/10.2478/pjct-2024-0031 | Journal eISSN: 3072-0389

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Language: English

Page range: 63 - 69

Published on: Sep 26, 2024

Published by: West Pomeranian University of Technology, Szczecin

In partnership with: Paradigm Publishing Services

Publication frequency: Volume open

Keywords:

Curcumin,

Carboxymethyl cellulose,

α-Amylase,

α-Glucosidase,

Diabetes mellitus treatment

Related subjects:

Industrial chemistry,

Biotechnology,

Chemical engineering,

Process engineering

© 2024 Abdulrahman A. Almehizia, Mohamed A. Al-Omar, Abdulrahman M. Al-Obaid, Ahmed M. Naglah, Mashooq A. Bhat, Hazem A. Ghabbour, Tamer K. Khatab, Ashraf S. Hassan, published by West Pomeranian University of Technology, Szczecin
This work is licensed under the Creative Commons Attribution 4.0 License.

Volume 26 (2024): Issue 3 (September 2024)