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The Effect of Aflatoxin B1 on Memory Processes, Morphological and Biochemical Blood Parameters of Mice Cover

The Effect of Aflatoxin B1 on Memory Processes, Morphological and Biochemical Blood Parameters of Mice

Open Access
|Sep 2026

References

  1. Lopes P, Sobral MMC, Lopes GR, Martins ZE, Passos CP, Petronilho S, Ferreira IMPLVO. Mycotoxins’ Prevalence in Food Industry By- Products: A Systematic Review. Toxins (Basel). 2023 Mar 29;15(4):249. doi: 10.3390/toxins15040249. PMID: 37104187; PMCID: PMC10142126.
  2. Barabasz W, Pikulicka A. Mykotoksyny – zagrożenie dla zdrowia ludzi i zwierząt. Część 1. Mykotoksyny – charakterystyka, występowanie, toksyczność dla organizmów. J HealthStudy Med. 2017; 3: 65–108.
  3. Pleadin J, Frece J, Markov K. Mycotoxins in food and feed. Adv Food Nutr Res. 2019;89:297-345. doi: 10.1016/bs.afnr.2019.02.007. Epub 2019 Mar 6. PMID: 31351529.
  4. Richard J.L.: Some major mycotoxins and their mycotoxicoses- an overview. Int. J. Food Microbiol., 2007; 119: 3-10.
  5. Lai X., Zhang H., Liu R., Liu C.: Potential for aflatoxin B1 and B2production by Aspergillus flavus strains isolated from rice samples.Saudi J. Biol. Sci., 2015; 22: 176-180.
  6. Ülger TG, Uçar A, Çakıroğlu FP, Yilmaz S. Genotoxic effects of mycotoxins. Toxicon. 2020 Oct 15;185:104-113. doi: 10.1016/j.toxicon.2020.07.004. Epub 2020 Jul 10. PMID: 32653416.
  7. World Health Organization (WHO), International Agency for Research on Cancer (IARC): Monographs on the Evaluation of Carcinogenic Risks to Humans. Some Naturally Occuring Substances: Food Items and Constituents, Heterocyclic Aromatic Amines and Mycotoxins. Lyon, France 56, 1993 http://monographs.iarc.fr/ENG/Monographs/vol56/mono56.pdf (cited on May 10-th2025).
  8. Meissonnier GM, Pinton P, Laffitte J, et al. Immunotoxicity of aflatoxin B1: impairment of the cell-mediated response to vaccine antigen and modulation of cytokine expression. ToxicolApplPharmacol. 2008;231(2):142-149.
  9. Abia W.A., Warth B., Sulyok M., Krska R., Tchana A., NjobehP.B.,Turner P.C., Kouanfack C., Eyongetah M., Dutton M., MoundipaP.F.:Biomonitoring of mycotoxin exposure in Cameroon using a urinarymulti-biomarker approach. Food Chem. Toxicol., 2013; 62: 927-934.
  10. Skrzydlewski P, Twarużek M, Grajewski J. Cytotoxicity of Mycotoxins and Their Combinations on Different Cell Lines: A Review. Toxins (Basel). 2022 Mar 30;14(4):244. doi: 10.3390/toxins14040244. PMID: 35448853; PMCID: PMC9031280.
  11. Arce-López B, Alvarez-Erviti L, De Santis B, Izco M, López-Calvo S, Marzo-Sola ME, Debegnach F, Lizarraga E, López de Cerain A, González- Peñas E, Vettorazzi A. Biomonitoring of Mycotoxins in Plasma of Patients with Alzheimer’s and Parkinson’s Disease. Toxins (Basel). 2021 Jul 10;13(7):477. doi: 10.3390/toxins13070477. PMID: 34357949; PMCID: PMC8310068.
  12. Nguyen VTT, König S, Eggert S, Endres K, Kins S. The role of mycotoxins in neurodegenerative diseases: current state of the art and future perspectives of research. Biol Chem. 2021 Aug 27;403(1):3-26. doi: 10.1515/hsz-2021-0214. PMID: 34449171.
  13. . Borzecki, P., Borzecka, A., Chylinska-Wrzos, P., Lis-Sochocka, M., Wawryk-Gawda, E., &Jodlowska-Jedrych, B. (2019). Evaluation of interleukin-6 concentration in the liver of Albino Swiss mice after intoxication with various doses of patulin, Current Issues in Pharmacy and Medical Sciences, 32(1), 34-39.
  14. Nasuti C, Fattoretti P, Carloni M, Fedeli D, Ubaldi M, Ciccocioppo R, Gabbianelli R. Neonatal exposure to permethrin pesticide causes life long fear and spatial learning deficits and Walters hippocampal morphology of synapses. Journal of Neurodevelopmental Disorders 2014; 6(1):7-15.
  15. Gugliandolo E, Peritore AF, D’Amico R, Licata P, Crupi R. Evaluation of Neuroprotective Effects of Quercetin against Aflatoxin B1-Intoxicated Mice. Animals (Basel). 2020 May 21;10(5):898. doi: 10.3390/ani10050898. PMID: 32455780; PMCID: PMC7278413.
  16. Yang C, Jiang W, Su D, Yang C, Yuan Q, Kang C, Xiao C, Wang L, Peng C, Zhou T, Zhang J. Contamination of the traditional medicine Radix Dipsaci with aflatoxin B1 impairs hippocampal neurogenesis and cognitive function in a mouse model of osteoporosis. Ecotoxicol Environ Saf. 2024 Sep 15;283:116831. doi: 10.1016/j.ecoenv.2024.116831. Epub 2024 Aug 15. PMID: 39151374.
  17. Mrozikiewicz, P. M.; Bogacz, A. Wpływ Leków Na Wyniki Badań Laboratoryjnych- Wybrane Przykłady Interferencji. Medycyna po Dyplomie 2013, 22 (6), 42–48.
  18. Zhang M, Li Q, Wang J, Sun J, Xiang Y, Jin X. Aflatoxin B1 disrupts the intestinal barrier integrity by reducing junction protein and promoting apoptosis in pigs and mice. Ecotoxicol Environ Saf. 2022 Dec 1;247:114250. doi: 10.1016/j.ecoenv.2022.114250. Epub 2022 Nov 2. PMID: 36334341.
  19. Tchana AN, Moundipa PF, Tchouanguep FM. Aflatoxin contamination in food and body fluids in relation to malnutrition and cancer status in Cameroon. Int. J. Environ. Res. Public Health. 2010;7:178–188. doi: 10.3390/ijerph7010178
  20. Owumi S, Najophe ES, Farombi EO, Oyelere AK. Gallic acid protects against Aflatoxin B1 -induced oxidative and inflammatory stress damage in rats kidneys and liver. J. Food Biochem. 2020;44:e13316. doi: 10.1111/jfbc.13316.
  21. Shin KT, Guo J, Niu YJ, Cui XS. The toxic effect of aflatoxin B1 on early porcine embryonic development. Theriogenology. 2018;118:157–163. doi: 10.1016/j.theriogenology.2018.06.002.
  22. Huang B, et al. Aflatoxin B1 Induces Neurotoxicity through reactive oxygen species generation, DNA damage, apoptosis, and s-phase cell cycle arrest. Int. J. Mol. Sci. 2020 doi: 10.3390/ijms21186517
  23. Owumi SE, Adedara IA, Akomolafe AP, Farombi EO, Oyelere AK. Gallic acid enhances reproductive function by modulating oxido-inflammatory and apoptosis mediators in rats exposed to aflatoxin-B1. Exp. Biol. Med. (Maywood) 2020;245:1016–1028. doi: 10.1177/1535370220936206.
  24. Mary VS, Theumer MG, Arias SL, Rubinstein HR. Reactive oxygen species sources and biomolecular oxidative damage induced by aflatoxin B1 and fumonisin B1 in rat spleen mononuclear cells. Toxicology. 2012;302:299–307. doi: 10.1016/j.tox.2012.08.012.
  25. Adedara IA, Owumi SE, Uwaifo AO, Farombi EO. Aflatoxin B1 and ethanol co-exposure induces hepatic oxidative damage in mice. Toxicol. Ind. Health. 2010;26:717–724. doi: 10.1177/0748233710377772.
  26. Baptista AS, et al. Utilization of diets amended with yeast and amino acids for the control of aflatoxicosis. World J. Microbiol. Biotechnol. 2008;24:2547–2554. doi: 10.1007/s11274-008-9776-5.
  27. Colakoglu F, Donmez HH. Effects of aflatoxin on liver and protective effectiveness of esterified glucomannan in merino rams. Sci. World J. 2012;2012:462925. doi: 10.1100/2012/462925.
  28. Yaman T, Yener Z, Celik I. Histopathological and biochemical investigations of protective role of honey in rats with experimental aflatoxicosis. BMC Complement. Altern. Med. 2016;16:232–232. doi: 10.1186/s12906-016-1217-7.
  29. Eraslan G, et al. The effects of diosmin on aflatoxin-induced liver and kidney damage. Environ. Sci. Pollut. Res. 2017;24:27931–27941. doi: 10.1007/s11356-017-0232-7.
  30. Imbabi TA, El-Sayed AI, El-Habbak MH, Nasr MA, Halawa EH. Ameliorative effects of silymarin on aflatoxin B1 toxicity in weaned rabbits: impact on growth, blood profile, and oxidative stress. Sci Rep. 2024 Sep 17;14(1):21666. doi: 10.1038/s41598-024-70623-z. PMID: 39289432; PMCID: PMC11408635.
DOI: https://doi.org/10.2478/phr-2025-0013 | Journal eISSN: 2084-0535 | Journal ISSN: 1734-7009
Language: English
Page range: 73 - 82
Submitted on: Feb 24, 2025
Accepted on: Mar 14, 2025
Published on: Sep 5, 2026
Published by: Polish Hyperbaric Medicine and Technology Society
In partnership with: Paradigm Publishing Services

© 2026 Agnieszka Radzka-Pogoda, Barbara Nieradko-Iwanicka, published by Polish Hyperbaric Medicine and Technology Society
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.