No evidence of the long-term in vitro toxicity of Aeroxide P25 TiO2 nanoparticles in three mammalian cell lines despite the initial reduction of cellular mitochondrial activity

Męczyńska-Wielgosz, Sylwia; Bartłomiejczyk, Teresa; Grądzka, Iwona; Sommer, Sylwester; Węgierek-Ciuk, Aneta; Lankoff, Anna; Sikorska, Katarzyna; Wojewódzka, Maria; Dobrzyńska, Małgorzata; Kruszewski, Marcin

doi:10.2478/nuka-2024-0002

References

McIntyre, R. A. (2012). Common nano-materials and their use in real world applications.Sci. Prog., 95,1-22. https://doi.org/10.3184/00368501 2X13294715456431.
Open DOI Search in Google Scholar Back to article
Ling, C., An, H., Li, L., Wang, J., Lu, T, Wang, H., Hu, Y., Song, G., Liu, S. (2021). Genotoxicity evaluation of titanium dioxide nanoparticles in vitro: a systematic review of the literature and meta-analysis.Biol. Trace Elem. Res., 199,2057-2076. https://doi.org/10.1007/s12011-020-02311-8.
Open DOI Search in Google Scholar Back to article
Woodruff, R. S., Li, Y, Yan, J., Bishop, M., Jones, M. Y, Watanabe, F., Biris, A. S., Rice, P., Zhou, T, Chen, T. (2012). Genotoxicity evaluation of titanium dioxide nanoparticles using the Ames test and comet assay.J. Appl. Toxicol., 32,934-943. https://doi.org/10.1002/jat.2781.
Open DOI Search in Google Scholar Back to article
Wang, S., Hunter, L. A., Arslan, Z., Wilkerson, M. G., Wickliffe, J. K. (2011). Chronic exposure to nanosized, anatase titanium dioxide is not cyto-or genotoxic to Chinese hamster ovary cells.Environ. Mol. Mutagen., 52,614-622. https://doi.org/10.1002/em.20660.
Open DOI Search in Google Scholar Back to article
Guichard, Y, Schmit, J., Darne, C., Gate, L., Goutet, M., Rousset, D., Rastoix, O., Wrobel, R., Witschger,O., Martin, A., Fierro, V, Binet, S. (2012). Cytotoxicity and genotoxicity of nanosized and microsized titanium dioxide and iron oxide particles in Syrian hamster embryo cells.Ann. Occup. Hyg., 56,631-644. https://doi.org/10.1093/annhyg/mes006.
Open DOI Search in Google Scholar Back to article
Kazimirova, A., Baranokova, M., Staruchova, M., Drlickova, M., Volkovova, K., Dusinska, M. (2019). Titanium dioxide nanoparticles tested for genotoxicity with the comet and micronucleus assays in vitro, ex vivo and in vivo.Mutat. Res., 843,57-65. https://doi.org/10.1016/j.mrgentox.2019.05.001.
Open DOI Search in Google Scholar Back to article
Valdiglesias, V, Costa, C., Sharma, V, Kilic, G., Pasaro, E., Teixeira, J. P., Dhawan, A., Laffon, B. (2013). Comparative study on effects of two different types of titanium dioxide nanoparticles on human neuronal cells.Food Chem. Toxicol., 57,352-361. https://doi.org/10.1016/j.fct.2013.04.010.
Open DOI Search in Google Scholar Back to article
Lankoff, A., Sandberg, W J., Wegierek-Ciuk, A., Lisowska, H., Refsnes, M., Sartowska, B., Schwarze, P. E., Meczynska-Wielgosz, S., Wojewodzka, M., Kruszewski, M. (2012). The effect of agglomeration state of silver and titanium dioxide nanoparticles on cellular response of HepG2, A549 and THP-1 cells.Toxicol. Lett., 208,197-213. https://doi.org/ S0378-4274(11)01606-7 [pii]; DOI: 10.1016/j.tox-let.2011.11.006.
Open DOI Search in Google Scholar Back to article
Wojewodzka, M., Kruszewski, M., Iwanenko, T., Collins, A. R., Szumiel, I. (1998). Application of the comet assay for monitoring DNA damage in workers exposed to chronic low-dose irradiation. I. Strand breakage.Mutat. Res.,416, 21-35.
Search in Google Scholar Back to article
Kruszewski, M., Wojewodzka, M., Iwanenko, T., Collins, A. R., Szumiel, I. (1998). Application of the comet assay for monitoring DNA damage in workers exposed to chronic low-dose irradiation. II. Base damage.Mutat. Res., 416,37-57.
Search in Google Scholar Back to article
Kruszewski, M., Gradzka, I., Bartlomiejczyk, T, Chwastowska, J., Sommer, S., Grzelak, A., Zuberek, M., Lankoff, A., Dusinska, M., Wojewodzka, M. (2013). Oxidative DNA damage corresponds to the long term survival of human cells treated with silver nanoparticles.Toxicol. Lett., 219,151-159. https://doi.org/S0378-4274(13)00104-5 [pii]; DOI: 10.1016/j.toxlet.2013.03.006.
Open DOI Search in Google Scholar Back to article
Eckl, P. M. (1995). Aquatic genotoxicity testing with rat hepatocytes in primary culture. II. Induction of micronuclei and chromosomal aberrations.Sci. Total Environ., 159,81-89.
Search in Google Scholar Back to article
Fotakis, G., Timbrell, J. A. (2006). In vitro cytotoxicity assays: comparison of LDH, neutral red, MTT and protein assay in hepatoma cell lines following exposure to cadmium chloride.Toxicol. Lett., 160,171-177.
Search in Google Scholar Back to article
Repetto, G. P. A. del, Zurita, J. L. (2008). Neutral red uptake assay for the estimation of cell viability/ cytotoxicity.Nat. Protoc.,3, 1125-1131.
Search in Google Scholar Back to article
Reeves, J. F., Davies, S. J., Dodd, N. J., Jha, A. N. (2008). Hydroxyl radicals (*OH) are associated with titanium dioxide (TiO(2)) nanoparticle-induced cytotoxicity and oxidative DNA damage in fish cells.Mutat. Res., 640,113-122.
Search in Google Scholar Back to article
Liu, S., Xu, L., Zhang, T, Ren, G., Yang, Z. (2010). Oxidative stress and apoptosis induced by nanosized titanium dioxide in PC12 cells.Toxicology, 267, 172-177.
Search in Google Scholar Back to article
Shukla, R. K., Sharma, V., Pandey, A. K., Singh, S., Sultana, S., Dhawan, A. (2011). ROS-mediated genotoxicity induced by titanium dioxide nanoparticles in human epidermal cells.Toxi col. Vitro,25, 231-241.
Search in Google Scholar Back to article
Wang, J., Li, N., Zheng, L., Wang, S., Wang, Y, Zhao, X., Duan, Y., Cui, Y., Zhou, M., Cai, J., Gong, S., Wang, H., Hong, F. (2011). P38-Nrf-2 signaling pathway of oxidative stress in mice caused by nanoparticulate TiO(2).Biol. Trace Elem. Res., 140(2), 186-197. DOI: 10.1007/s12011-010-8687-0.
Open DOI Search in Google Scholar Back to article
Trouiller, B., Reliene, R., Westbrook, A., Solaimani, P., Schiestl, R. H. (2009). Titanium dioxide nanoparticles induce DNA damage and genetic instability in vivo in mice.Cancer Res.,69, 8784-8789.
Search in Google Scholar Back to article
Singh, N., Manshian, B., Jenkins, G. J., Griffiths, S. M., Williams, P. M., Maffeis, T G., Wright, C. J., Doak, S. H. (2009). NanoGenotoxicology: the DNA damaging potential of engineered nanomaterials.Biomaterials, 30,3891-3914.
Search in Google Scholar Back to article
Shi, H., Magaye, R., Castranova, V, Zhao, J. (2013). Titanium dioxide nanoparticles: a review of current toxicological data.Part Fibre Toxicol.,10, 15. https://doi.org/1743-8977-10-15 [pii]; DOI: 10.1186/1743-8977-10-15.
Open DOI Search in Google Scholar Back to article
Stepkowski, T. M., Brzoska, K., Kruszewski, M. (2014). Silver nanoparticles induced changes in the expression of NF-kappaB related genes are cell type specific and related to the basal activity of NF-kappaB.Toxicol. Vitro, 28,473-478. https://doi.org/S0887-2333(14)00011-3 [pii]; DOI: 10.1016/j. tiv.2014.01.008.
Open DOI Search in Google Scholar Back to article
Neijenhuis, S., Verwijs-Janssen, M., Kasten-Pisula, U., Rumping, G., Borgmann, K., Dikomey, E., Begg, A. C., Vens, C. (2009). Mechanism of cell killing after ionizing radiation by a dominant negative DNA polymerase beta.DNA Repair,8, 336-346.
Search in Google Scholar Back to article
Ahamed, M., Karns, M., Goodson, M., Rowe, J., Hussain, S. M., Schlager, J. J., Hong, J. (2008). DNA damage response to different surface chemistry of silver nanoparticles in mammalian cells.Toxicol. Appl.Pharmacol., 233,404-410.
Search in Google Scholar Back to article
Lobrich, M., Shibata, A., Beucher, A., Fisher, A., Ensminger, M., Goodarzi, A. A., Barton, O., Jeggo, P. A. (2010). GammaH2AX foci analysis for monitoring DNA double-strand break repair: strengths, limitations and optimization.Cell Cycle, 9,662-669.
Search in Google Scholar Back to article
Matsumoto, M., Yaginuma, K., Igarashi, A., Imura, M., Hasegawa, M., Iwabuchi, K., Date, T, Mori, T, Ishizaki, K., Yamashita, K., Inobe, M., Matsunaga, T (2007). Perturbed gap-filling synthesis in nucleotide excision repair causes histone H2AX phosphorylation in human quiescent cells.J. Cell. Sci., 120,1104-1112.
Search in Google Scholar Back to article
Rogakou, E. P., Nieves-Neira, W, Boon, C., Pommier, Y., Bonner, W M. (2000). Initiation of DNA fragmentation during apoptosis induces phosphorylation of H2AX histone at serine 139.J. Biol. Chem., 275,9390-9395.
Search in Google Scholar Back to article
Zuberek, M., Grzelak, A. (2018). Nanoparticles-caused oxidative imbalance.Adv. Exp. Med. Biol.,1048,85-98. https://doi.org/10.1007/978-3-319-72041-8_6.
Open DOI Search in Google Scholar Back to article

No evidence of the long-term in vitro toxicity of Aeroxide P25 TiO2 nanoparticles in three mammalian cell lines despite the initial reduction of cellular mitochondrial activity

References

Paradigm

My account