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Design and fabrication of 125I seeds for brachytherapy using capillary-based microfluidic technique Cover

Design and fabrication of 125I seeds for brachytherapy using capillary-based microfluidic technique

Nukleonika
Volume 66 (2021): Issue 2 (June 2021)
By: Yuan Wang,  Miao Zhang,  Tong Song and  Zhenqi Chang  
Open Access
|Jun 2021

Figures & Tables

Fig. 1

Schematic drawing of capillary-based microfluidic device for synthesis of core-shell microspheres. Inner/outer diameter of the outside capillary (1) is 255 μm/510 μm, and inner/outer diameter of the inner capillary (2) is 100 μm/167 μm.

Fig. 2

(a1–a3) Formation of core-shell structure droplet, Q1 = 120 μL/min, Q2 = 3.75 μL/min, Q3 = 0.25 μL/min; (b) optical image of as-prepared 125I seeds.

Fig. 3

Optical images of 125I seeds with a various core diameter and the same overall diameter of 600 μm. (a) Core diameter of 400 μm, Q1 = 120 μL/min, Q2 = 3 μL/min, Q3 = 1 μL/min, the radioactivity of a single 125I-encapsulated microsphere was about 0.17 mCi; (b) core diameter of 200 μm, Q1 = 120 μL/min, Q2 = 3.83 μL/min, Q3 = 0.17 μL/min, the radioactivity of a single 125I-encapsulated microsphere was about 0.02 mCi.

Fig. 4

Isodose curves of the 125I brachytherapy sources with different orientation of cores in the sources. Overall diameter of the 125I seeds was 600 μm, and core diameter was 300 μm. (a) Each seed of core and shell is of homocentricity. (b–d) Each seed of core and shell was of nonhomocentricity.

Fig. 5

Isodose curves of the 125I brachytherapy sources with different core size under the same orientation in the source. Each seed diameter was 600 μm, and core diameter was (a) 150 μm, (b) 300 μm, (c) 400 μm, and (d) 500 μm.

Fig. 6

Isodose curves of the 125I brachytherapy sources with a different orientation of the cores. Overall diameter of the 125I seeds was 600 μm, and the diameter of core was 500 μm.

Fig. 7

Optical image of a 125I brachytherapy source consisted of six 125I seeds within a glass tubing. The overall diameter of the seeds was 600 μm, and the diameter of core was 500 μm.
DOI: https://doi.org/10.2478/nuka-2021-0007 | Journal eISSN: 1508-5791 | Journal ISSN: 0029-5922
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Language: English
Page range: 55 - 60
Submitted on: Mar 1, 2020
|
Accepted on: May 7, 2020
|
Published on: Jun 8, 2021
Published by: Institute of Nuclear Chemistry and Technology
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year
Keywords:
I seeds,
Brachytherapy source,
Microfluidic,
Monte Carlo calculation,
Core-shell
Related subjects:
Chemistry,
Nuclear chemistry,
Physics,
Astronomy and astrophysics,
Physics, other

© 2021 Yuan Wang, Miao Zhang, Tong Song, Zhenqi Chang, published by Institute of Nuclear Chemistry and Technology
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

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