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Nanofibrous membranes loaded with bupivacaine and carica papaya extract for pain management and wound healing in postoperative wounds Cover

Nanofibrous membranes loaded with bupivacaine and carica papaya extract for pain management and wound healing in postoperative wounds

Materials Science-Poland
Volume 42 (2024): Issue 2 (June 2024)
By: Aiqin Zhang,  Shaik Althaf Hussain,  Turki Mayudh Alrubie and  Rong Jiang  
Open Access
|Sep 2024

Figures & Tables

Fig. 1.

Schematic illustration representing the fabrication process of BUPCPEPCLPVA and PCLPVA scaffolds
Schematic illustration representing the fabrication process of BUPCPEPCLPVA and PCLPVA scaffolds

Fig. 2.

SEM images of (A) BUPCPEPCLPVA and (B) PCLPVA
SEM images of (A) BUPCPEPCLPVA and (B) PCLPVA

Fig. 3.

Release of bupivacaine and carica papaya extract from the matrix of BUPCPEPCLPVA scaffolds over the course of 48 hour
Release of bupivacaine and carica papaya extract from the matrix of BUPCPEPCLPVA scaffolds over the course of 48 hour

Fig. 4.

Radical scavenging activity of BUPCPEPCLPVA and PCLPVA scaffolds compared with ascorbic acid as the control group, * shows p-value < 0.05
Radical scavenging activity of BUPCPEPCLPVA and PCLPVA scaffolds compared with ascorbic acid as the control group, * shows p-value < 0.05

Fig. 5.

MTT assay with L929 cells cultured on BUPCPEPCLPVA and PCLPVA scaffolds compared with the cells cultured on tissue culture plate as the control group
MTT assay with L929 cells cultured on BUPCPEPCLPVA and PCLPVA scaffolds compared with the cells cultured on tissue culture plate as the control group

Fig. 6.

Concentrations of TNF-a and IL-6 in the supernatant of RAW 264.7 murine macrophage cells cultured on BUPCPEPCLPVA and PCLPVA scaffolds, * shows p-value < 0.05
Concentrations of TNF-a and IL-6 in the supernatant of RAW 264.7 murine macrophage cells cultured on BUPCPEPCLPVA and PCLPVA scaffolds, * shows p-value < 0.05

Fig. 7.

In vitro wound closure assessment with L929 cells cultured with (A) BUPCPEPCLPVA scaffolds extract, (B) PCLPVA scaffolds’ extract, (C) normal culture media as the control group, * shows p-value < 0.05
In vitro wound closure assessment with L929 cells cultured with (A) BUPCPEPCLPVA scaffolds extract, (B) PCLPVA scaffolds’ extract, (C) normal culture media as the control group, * shows p-value < 0.05

Fig. 8.

MTT assay with L929 fibroblast cells cultured with the extract of BUPCPEPCLPVA and PCLPVA scaffolds under oxidative stress induced by 1% H2O2, * shows p-value < 0.05
MTT assay with L929 fibroblast cells cultured with the extract of BUPCPEPCLPVA and PCLPVA scaffolds under oxidative stress induced by 1% H2O2, * shows p-value < 0.05

Fig. 9.

Wound closure study of wounds treated with BUPCPEPCLPVA and PCLPVA wound dressings on days 7 and 14 after wounding, * shows p-value < 0.05
Wound closure study of wounds treated with BUPCPEPCLPVA and PCLPVA wound dressings on days 7 and 14 after wounding, * shows p-value < 0.05

Fig. 10.

Hematoxylin and Eosin (H&E) and Masson’s Trichrome (MT) staining images of wounds treated with (A) BUPCPEPCLPVA, (B) PCLPVA, and (C) control groups
Hematoxylin and Eosin (H&E) and Masson’s Trichrome (MT) staining images of wounds treated with (A) BUPCPEPCLPVA, (B) PCLPVA, and (C) control groups

Fig. 11.

Histomorphometric studies acquired from histopathological staining images in wounds treated with different wound dressings, * shows p-value < 0.05
Histomorphometric studies acquired from histopathological staining images in wounds treated with different wound dressings, * shows p-value < 0.05

Fig. 12.

Latency time for painful stimuli in wounds treated with BUPCPEPCLPVA and PCLPVA wound dressings compared with non-treated wounds as the control, * shows p-value < 0.05
Latency time for painful stimuli in wounds treated with BUPCPEPCLPVA and PCLPVA wound dressings compared with non-treated wounds as the control, * shows p-value < 0.05

Fig. 13.

ELISA assay results in wound tissues treated with BUPCPEPCLPVA and PCLPVA wound dressings at the end of the 14th day post-wounding, respectively
ELISA assay results in wound tissues treated with BUPCPEPCLPVA and PCLPVA wound dressings at the end of the 14th day post-wounding, respectively
DOI: https://doi.org/10.2478/msp-2024-0019 | Journal eISSN: 2083-134X | Journal ISSN: 2083-1331
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Language: English
Page range: 143 - 159
Submitted on: Mar 18, 2024
Accepted on: May 22, 2024
Published on: Sep 4, 2024
Published by: Wroclaw University of Science and Technology
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year
Keywords:
bupivacaine,
carica papaya extract,
wound dressing,
drug delivery,
nanofibers
Related subjects:
Materials sciences,
Materials sciences, other,
Nanomaterials,
Functional and smart materials,
Materials characterization and properties

© 2024 Aiqin Zhang, Shaik Althaf Hussain, Turki Mayudh Alrubie, Rong Jiang, published by Wroclaw University of Science and Technology
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

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