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In vitro investigation of anti-inflammatory activity of propolis/saffron extract/curcumin-loaded ZIF8 nanoparticles and their potential application for treating osteoarthritis Cover

In vitro investigation of anti-inflammatory activity of propolis/saffron extract/curcumin-loaded ZIF8 nanoparticles and their potential application for treating osteoarthritis

Materials Science-Poland
Volume 42 (2024): Issue 2 (June 2024)
By: Hongtao Zhang,  Kui Xu,  Zhen Zhao,  Chuan Dong and  Yunfei Zhang  
Open Access
|Jul 2024

Figures & Tables

Fig. 1.

Representative SEM imaging results for (A) ZIF, (B) PROZIF, (C) SAFROZIF, and (D) CURCUZIF nanocarriers and their size distribution
Representative SEM imaging results for (A) ZIF, (B) PROZIF, (C) SAFROZIF, and (D) CURCUZIF nanocarriers and their size distribution

Fig. 2.

MTT assay with L929 cells cultured with different concentrations of (A) PROZIF, (B) SAFROZIF, (C) CURCUZIF, and (D) ZIF nanoparticles, a, b, and e show p-values < 0.05 relative to 1 μg/mL, 10 μg/mL, and control groups, respectively
MTT assay with L929 cells cultured with different concentrations of (A) PROZIF, (B) SAFROZIF, (C) CURCUZIF, and (D) ZIF nanoparticles, a, b, and e show p-values < 0.05 relative to 1 μg/mL, 10 μg/mL, and control groups, respectively

Fig. 3.

Histograms comparing the anti-inflammatory activity of (A) PROZIF, (B) SAFROZIF, (C) CURCUZIF, and (D) ZIF nanoparticles at different concentrations, a, b, c, and d show p-value < 0.05 relative to 1 μg/mL, 10 μg/mL, 100 μg/mL, and 1000 μg/mL concentrations, respectively
Histograms comparing the anti-inflammatory activity of (A) PROZIF, (B) SAFROZIF, (C) CURCUZIF, and (D) ZIF nanoparticles at different concentrations, a, b, c, and d show p-value < 0.05 relative to 1 μg/mL, 10 μg/mL, 100 μg/mL, and 1000 μg/mL concentrations, respectively

Fig. 4.

Histograms comparing the anti-inflammatory activity of ZIF, PROZIF, SAFROZIF, and CURCUZIF at (A) 1 μg/mL, (B) 10 μg/mL, (C) 100 μg/mL, and (D) 1000 μg/mL concentrations
Histograms comparing the anti-inflammatory activity of ZIF, PROZIF, SAFROZIF, and CURCUZIF at (A) 1 μg/mL, (B) 10 μg/mL, (C) 100 μg/mL, and (D) 1000 μg/mL concentrations

Fig. 5.

Cell migration assay with L929 cells cultured with different nanocarriers on day 0 (left panel), day 1 (middle panel), and day 2 (right panel), a shows p-value < 0.05 relative to PROZIF group
Cell migration assay with L929 cells cultured with different nanocarriers on day 0 (left panel), day 1 (middle panel), and day 2 (right panel), a shows p-value < 0.05 relative to PROZIF group

Fig. 6.

FTIR spectra of ZIF, PROZIF, SAFROZIF, and CURCUZIF nanoparticles
FTIR spectra of ZIF, PROZIF, SAFROZIF, and CURCUZIF nanoparticles

Fig. 7.

Cumulative release profile of propolis, saffron extract, and curcumin from PROZIF, SAFROZIF, and CURCUZIF during the course of 7 days in PBS
Cumulative release profile of propolis, saffron extract, and curcumin from PROZIF, SAFROZIF, and CURCUZIF during the course of 7 days in PBS
DOI: https://doi.org/10.2478/msp-2024-0016 | Journal eISSN: 2083-134X | Journal ISSN: 2083-1331
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Language: English
Page range: 41 - 51
Submitted on: Apr 21, 2024
Accepted on: May 19, 2024
Published on: Jul 11, 2024
Published by: Wroclaw University of Science and Technology
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year
Keywords:
osteoarthritis,
zeolitic imidazolate framework,
nanoparticles,
drug delivery,
propolis,
saffron extract,
curcumin
Related subjects:
Materials sciences,
Materials sciences, other,
Nanomaterials,
Functional and smart materials,
Materials characterization and properties

© 2024 Hongtao Zhang, Kui Xu, Zhen Zhao, Chuan Dong, Yunfei Zhang, published by Wroclaw University of Science and Technology
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

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