The Impact of Microplastics and Nanoplastics on Human Health: A Follow-Up Study Focusing on Endocrine, Nervous, and Immune Systems
References
- Statista Research Department. Annual production of plastics worldwide from 1950 to 2023. 2025.
- Hartmann NB, Hüffer T, Thompson RC, Hassellöv M, Verschoor A, Daugaard AE, et al. Are We Speaking the Same Language? Recommendations for a Definition and Categorization Framework for Plastic Debris. Environ Sci Technol 2019;53:1039–47. https://doi.org/10.1021/acs.est.8b05297.
- Li P, Wang X, Su M, Zou X, Duan L, Zhang H. Characteristics of Plastic Pollution in the Environment: A Review. Bull Environ Contam Toxicol 2021;107:577–84. https://doi.org/10.1007/s00128-020-02820-1.
- Li Y, Tao L, Wang Q, Wang F, Li G, Song M. Potential Health Impact of Microplastics: A Review of Environmental Distribution, Human Exposure, and Toxic Effects. Environment & Health 2023;1:249–57. https://doi.org/10.1021/envhealth.3c00052.
- Stoian AI. The Impact of Microplastics and Nanoplastics on Human Digestive, Respiratory and Cardiovascular Systems. International Conference KNOWLEDGE-BASED ORGANIZATION 2024;30:146–52. https://doi.org/10.2478/kbo-2024-0097.
- Ali N, Katsouli J, Marczylo EL, Gant TW, Wright S, Bernardino de la Serna J. The potential impacts of micro-and-nano plastics on various organ systems in humans. EBioMedicine 2024;99:104901. https://doi.org/10.1016/j.ebiom.2023.104901.
- Wawer J, Panuszko A, Kozłowski D, Juniewicz J, Szymikowski J, Brodnicka E. Sustainable Management of Microplastic Pollutions from PET Bottles: Overview and Mitigation Strategies. Applied Sciences 2025;15:5322. https://doi.org/10.3390/app15105322.
- Vanetti C, Broggiato M, Pezzana S, Clerici M, Fenizia C. Effects of microplastics on the immune system: How much should we worry? Immunol Lett 2025;272:106976. https://doi.org/10.1016/j.imlet.2025.106976.
- Cao J, Yang Q, Jiang J, Dalu T, Kadushkin A, Singh J, et al. Coronas of micro/nano plastics: a key determinant in their risk assessments. Part Fibre Toxicol 2022;19:55. https://doi.org/10.1186/s12989-022-00492-9.
- Ali N, Katsouli J, Marczylo EL, Gant TW, Wright S, Bernardino de la Serna J. The potential impacts of micro-and-nano plastics on various organ systems in humans. EBioMedicine 2024;99:104901. https://doi.org/10.1016/j.ebiom.2023.104901.
- Ullah S, Ahmad S, Guo X, Ullah S, Ullah S, Nabi G, et al. A review of the endocrine disrupting effects of micro and nano plastic and their associated chemicals in mammals. Front Endocrinol (Lausanne) 2023;13. https://doi.org/10.3389/fendo.2022.1084236.
- Wang M, Wu Y, Li G, Xiong Y, Zhang Y, Zhang M. The hidden threat: Unraveling the impact of microplastics on reproductive health. Science of The Total Environment 2024;935:173177. https://doi.org/10.1016/j.scitotenv.2024.173177.
- Hwang K-S, Son Y, Kim SS, Shin D-S, Lim SH, Yang JY, et al. Size-Dependent Effects of Polystyrene Nanoparticles (PS-NPs) on Behaviors and Endogenous Neurochemicals in Zebrafish Larvae. Int J Mol Sci 2022;23:10682. https://doi.org/10.3390/ijms231810682.
- Zheng Y, Xu S, Liu J, Liu Z. The effects of micro- and nanoplastics on the central nervous system: A new threat to humanity? Toxicology 2024;504:153799. https://doi.org/10.1016/j.tox.2024.153799.
- Moiniafshari K, Zanut A, Tapparo A, Pastore P, Bogialli S, Abdolahpur Monikh F. A perspective on the potential impact of microplastics and nanoplastics on the human central nervous system. Environ Sci Nano 2025;12:1809–20. https://doi.org/10.1039/D4EN01017E.
- Yang W, Jannatun N, Zeng Y, Liu T, Zhang G, Chen C, et al. Impacts of microplastics on immunity. Frontiers in Toxicology 2022;4. https://doi.org/10.3389/ftox.2022.956885.
- Huang H, Hou J, Liao Y, Wei F, Xing B. Polyethylene microplastics impede the innate immune response by disrupting the extracellular matrix and signaling transduction. IScience 2023;26:107390. https://doi.org/10.1016/j.isci.2023.107390.
- Bora SS, Gogoi R, Sharma MR, Anshu, Borah MP, Deka P, et al. Microplastics and human health: unveiling the gut microbiome disruption and chronic disease risks. Front Cell Infect Microbiol 2024;14. https://doi.org/10.3389/fcimb.2024.1492759.
- Lihua C, Zhiyin T. Microplastics aggravates rheumatoid arthritis by affecting the proliferation/migration/inflammation of fibroblast-like synovial cells by regulating mitochondrial homeostasis. Int Immunopharmacol 2023;120:110268. https://doi.org/10.1016/j.intimp.2023.110268.
DOI: https://doi.org/10.2478/kbo-2025-0092 | Journal eISSN: 2451-3113
Language: English
Page range: 160 - 167
Published on: Jul 5, 2025
Published by: Nicolae Balcescu Land Forces Academy
In partnership with: Paradigm Publishing Services
Publication frequency: 3 issues per year
Related subjects:
© 2025 Adrian Ioan Stoian, published by Nicolae Balcescu Land Forces Academy
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.