Impact of copper deficiency in cows on immune system function in offspring: a study using lymphocyte immunophenotyping
References
- Abramowicz B., Kurek Ł., Dębiak P., Madany J., Lutnicki K.: Hematological parameters in dairy cows with copper deficiency. J Elem 2019, 24, 501–510, doi: 10.5601/jelem.2018.23.4.1668.
- Abramowicz B., Szczepańska E., Wojtas N., Kurek Ł.: The evolution of metallothionein (ZnMT) levels and haematological parameters in clinical and subclinical forms of copper deficiency in dairy cattle. J Elem 2023, 28, 363–373, doi: 10.5601/jelem.2023.28.2.2402.
- Bonham M., O’Connor J.M., Hannigan B.M., Strain J.J.: The immune system as a physiological indicator of marginal copper status? Br J Nutr 2002, 87, 393–403, doi: 10.1079/BJN2002558.
- Cerone S.I., Sansinanea A.S., Streiberger S.A., Garcia M.C., Auza N.J.: Cytochrome c oxidase, Cu, Zn-superoxide dismutase, and ceruloplasmin activities in copper-deficient bovines. Biol Trace El Res 2000, 73, 269–278, doi: 10.1385/BTER:73:3:269.
- Cerone S.I., Sansinanea A.S., Streitenberger S.A., García M.C., Auza N.J.: Bovine monocyte-derived macrophage function in induced copper deficiency. Gen Physiol Biophys 2000, 19, 49–58.
- Cheng F., Peng G., Lu Y., Wang K., Ju Q., Ju Y., Ouyang M.: Relationship between copper and immunity: the potential role of copper in tumor immunity. Front Oncol 2022, 12, 1019153, doi: 10.3389/fonc.2022.1019153.
- Collins J.F., Prohaska J.R., Knutson M.D.: Metabolic crossroads of iron and copper. Nutr Rev 2010, 68, 133–147, doi: 10.1111/j.1753-4887.2010.00271.x.
- D’Angelo G.: Copper deficiency mimicking myelodysplastic syndrome. Blood Res 2016, 51, 217–219, doi: 10.5045/br.2016.51.4.217.
- Denholm S.J., McNeilly T.N., Banos G., Coffey M.P., Russell G.C., Bagnall A., Mitchell M.C., Wall E.: Estimating genetic and phenotypic parameters of cellular immune-associated traits in dairy cows. J Dairy Sci 2017, 100, 2850–2862, doi: 10.3168/jds.2016-11679.
- Doguer C., Ha J.H., Collins J.F.: Intersection of iron and copper metabolism in the mammalian intestine and liver. Compr Physiol 2018, 14, 1433–1461, doi: 10.1002/cphy.c170045.
- Gengelbach G.P., Ward J.D., Spears J.W., Brown T.T.: Effects of copper deficiency and copper deficiency coupled with high dietary iron or molybdenum on phagocytic cell function and response of calves to a respiratory disease challenge. J Anim Sci 1997, 75, 1112–1118, doi: 10.2527/1997.7541112x.
- Humphries W.R., Phillippo M., Young B.W., Bremner I.: The influence of dietary iron and molybdenum on copper metabolism in calves. Br J Nutr 1983, 49, 77–86, doi: 10.1079/BJN19830013.
- Ježek J., Nemec M., Starič J.O., Klinkon M.: Age-related changes and reference intervals of haematological variables in dairy calves. Bull Vet Inst Pulawy 2011, 55, 471–478.
- Lazarchick J: Update on anemia and neutropenia in copper deficiency. Curr Opin Hematol 2012, 19, 58–60, doi: 10.1097/MOH.0b013e32834da9d2.
- Libera K., Konieczny K., Witkowska K., Żurek K., Szumacher-Strabel M., Cieslak A., Smulski S.: The association between selected dietary minerals and mastitis in dairy cows – a review. Animals 2021, 11, 2330, doi: 10.3390/ani11082330.
- López-Alonso M., Miranda M.: Copper supplementation, a challenge in cattle. Animals 2020, 10, 1890, doi: 10.3390/ani10101890.
- Makau M.C., Powell J., Prendergast J., Latré de Laté P., Morrison L.J., Fisch A., Gathura P., Kitala P., Connelley T., Toye P.: Inverted CD4+/CD8+ T cell ratio in Boran (Bos indicus) cattle. Vet Immunol Immunopathol 2020, 230, 110126, doi: 10.1016/j.vetimm.2020.110126.
- Menzir A., Dessie D.: On copper deficiency in domestic ruminants awake. Int J Adv Res Publ 2017, 1, 101–110.
- Meyer D.J., Harvey J.W.: Veterinary laboratory medicine. Interpretation and Diagnosis, third edition. Saunders, Philadelphia, PA, USA, 2004.
- Mills C.F., Dalgarno A.C., Wenham C.: Biochemical and pathological changes in tissues of Friesian cattle during the experimental induction of copper deficiency. Br J Nutr 1976, 35, 309–331.
- National Academies of Science, Engineering and Medicine: Nutrient Requirements of Dairy Cattle: eighth revised edition, The National Academies Press, Washington, DC, USA, 2021, doi: 10.17226/25806.
- Naylor J.M., Kasari T.R., Blakley B.R., Townsend H.G.: Diagnosis of copper deficiency and effects of supplementation in beef cows. Can J Vet Res 1989, 53, 343–348.
- Pavelková M., Vysloužil J., Kubová K., Vetchý D.: Biological role of copper as an essential trace element in the human organism. Česká Slov Farmacie 2018, 67, 143–153, doi: 10.36290/csf.2018.021.
- Rodríguez A.M., López Valiente S., Mattioli G., Maresca S.: Effects of inorganic copper injection in beef cows at late gestation on fetal and postnatal growth, haematology and immune function of their progeny. Res Vet Sci 2021, 139, 11–17, doi: 10.1016/j.rvsc.2021.06.017.
- Šoch M., Brouček J., Šrejberova P.: Hematology and blood microelements of sheep in south Bohemia. Biologia 2011, 66, 181–186, doi: 10.2478/s11756-010-0150-3.
- Wierzbicka D., Gromadzka G.: Ceruloplasmin, hephaestin and zyklopen: the three multicopper oxidases important for human iron metabolism. Postępy Higieny Med Dośw 2014, 68, 912–924
DOI: https://doi.org/10.2478/jvetres-2026-0040 | Journal eISSN: 2450-8608 (formerly 2300-3235)
Language: English
Submitted on: Feb 13, 2026
Accepted on: Aug 7, 2026
Published on: Aug 12, 2026
Published by: National Veterinary Research Institute in Pulawy
In partnership with: Paradigm Publishing Services
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© 2026 Beata Abramowicz, Łukasz Kurek, Urszula Lisiecka, Katarzyna Żarczyńska, Anna Szczotka-Bochniarz, published by National Veterinary Research Institute in Pulawy
This work is licensed under the Creative Commons Attribution 4.0 License.