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The effect of parenteral betanin pre-treatment on the inflammatory response and proliferative activity of pulmonary parenchyma after jejunal ischaemia–reperfusion injury Cover

The effect of parenteral betanin pre-treatment on the inflammatory response and proliferative activity of pulmonary parenchyma after jejunal ischaemia–reperfusion injury

Open Access
|Nov 2025

References

  1. Abdeen S.M., Mathew T.C., Dashti H.M., Asfar S.: Protective effects of green tea on intestinal ischemia–reperfusion injury. Nutrition 2011, 27, 598–603, doi: 10.1016/j.nut.2010.05.014.
  2. Allegra M., Tesoriere L., Livrea M.A.: Betanin inhibits the myeloperoxidase/nitrite-induced oxidation of human low-density lipoproteins. Free Radical Res 2007, 41, 335–341, doi: 10.1080/10715760601038783.
  3. Azeredo H.M.C.: Betalains: properties, sources, applications, and stability – a review. Int J Food Tech 2009, 44, 2365–2376, doi: 10.1111/j.1365-2621.2007.01668.x.
  4. Bonner J.C., Rice A.B., Ingram J.L., Moomaw C.R., Nyska A., Bradbury A., Sessoms A.R., Chulada P.C., Morgan D.L., Zeldin D.C., Langenbach R.: Susceptibility of cyclooxygenase-2-deficient mice to pulmonary fibrogenesis. Am J Pathol 2002, 161, 459–470, doi: 10.1016/S0002-9440(10)64202-2.
  5. Casili G., Ardizzone A., Basilotta R., Lanza M., Filippone A., Paterniti I., Esposito E., Campolo M.: The protective role of prolyl oligopeptidase (POP) inhibition in kidney injury induced by renal ischemia–reperfusion. Int J Mol Sci 2021, 22, 11886, doi: 10.3390/ijms222111886.
  6. Chen W., Fu X.-B., Ge S.-L., Sun T.-Z., Li W.-J., Sheng Z.-Y.: Acid fibroblast growth factor reduces rat intestinal mucosal damage caused by ischemia-reperfusion insult. World J Gastroenterol 2005, 11, 6477, doi: 10.3748/wjg.v11.i41.6477.
  7. Cucolas C., Daneasa A.I., Olteanu D., Decea N., Moldovan R., Tabaran F., Filip G.A.: Resveratrol and curcumin as protective agents in an experimental rat model of intestinal ischemia and reperfusion. Can J Physiol Pharmacol 2016, 94, 1151–1158, doi: 10.1139/cjpp-2016-0085.
  8. Dhananjayan I., Kathiroli S., Subramani S., Veerasamy V.: Ameliorating effect of betanin, a natural chromoalkaloid by modulating hepatic carbohydrate metabolic enzyme activities and glycogen content in streptozotocin – nicotinamide induced experimental rats. Biomed Pharmacother 2017, 88, 1069–1079, doi: 10.1016/j.biopha.2017.01.146.
  9. Favarin D.C., Teixeira M.M., Andrade de E.L., Alves C. de F., Chica J.E.L., Sorgi C.A., Faccioli L.H., Rogerio A.P: Anti-inflammatory effects of ellagic acid on acute lung injury induced by acid in mice. Mediators Inflamm 2013, 2013, 164202, doi: 10.1155/2013/164202.
  10. Feitoza C.Q., Câmara N.S.O., Pinheiro H.S., Gonçalves G.M., Cenedeze M.A., Pacheco-Silva A., Santos O.F.P.: Cyclooxygenase 1 and/or 2 blockade ameliorates the renal tissue damage triggered by ischemia and reperfusion injury. Int Immunopharmacol 2005, 5, 79–84, doi: 10.1016/j.intimp.2004.09.024.
  11. Frutos-Vivar F., Nin N., Esteban A.: Epidemiology of acute lung injury and acute respiratory distress syndrome. Curr Opin Crit Care 2004, 10, 1–6, doi: 10.1097/00075198-200402000-00001.
  12. Fukunaga K., Kohli P., Bonnans C., Fredenburgh L.E., Levy B.D.: Cyclooxygenase 2 plays a pivotal role in the resolution of acute lung injury. J Immun 2005, 174, 5033–5039, doi: 10.4049/jimmunol.174.8.5033.
  13. Gliszczyńska-Świgło A., Szymusiak H., Malinowska P.: Betanin, the main pigment of red beet: molecular origin of its exceptionally high free radical-scavenging activity. Food Addit Contam 2006, 23, 1079–1087, doi: 10.1080/02652030600986032.
  14. Grotz M.R., Deitch E.A., Ding J., Xu D., Huang Q., Regel G.: Intestinal cytokine response after gut ischemia: role of gut barrier failure. Ann Surg 1999, 229, 478, doi: 10.1097/00000658-199904000-00005.
  15. Guzel A., Kanter M., Guzel A., Pergel A., Erboga M.: Anti-inflammatory and antioxidant effects of infliximab on acute lung injury in a rat model of intestinal ischemia/reperfusion J Mol Hist 2012, 43, 361–369, doi: 10.1007/s10735-012-9396-0.
  16. Han J., Ma D., Zhang M., Yang X., Tan D.: Natural antioxidant betanin protects rats from paraquat-induced acute lung injury interstitial pneumonia. BioMed Res Intern 2015, doi: 10.1155/2015/608174.
  17. Impellizzeri D., Cordaro M., Campolo M., Gugliandolo E., Esposito E., Benedetto F., Cuzzocrea S., Navarra M.: Anti-inflammatory and antioxidant effects of flavonoid-rich fraction of bergamot juice (BJe) in a mouse model of intestinal ischemia/reperfusion injury. Front Pharmacol 2016, 7, 203, doi: 10.3389/fphar.2016.00203.
  18. Kamel M., Ahmed S.M., Abdelzaher W.: The potential protective effect of modafinil in intestinal ischemic reperfusion-induced in rats. Int Immunopharmacol 2020, 88, 106983, doi: 10.1016/j.intimp.2020.106983.
  19. Kanner J., Harel S., Granit R.: Betalains – a new class of dietary cationized antioxidants. J Agric Food Chem 2001, 49, 5178–5185, doi: 10.1021/jf010456f.
  20. Kim K., Li Y., Jin G., Chong W., Liu B., Lu J., Lee K., Demoya M., Velmahos G.C., Alam H.B.: Effect of valproic acid on acute lung injury in a rodent model of intestinal ischemia reperfusion. Resuscitation 2012, 83, 243–248, doi: 10.1016/j.resuscitation.2011.07.029.
  21. Köksoy C., Kuzu M.A., Ergün H., Demirpençe E., Zülfikaroğlu B.: Intestinal ischemia and reperfusion impairs vasomotor functions of pulmonary vascular bed. Ann Surg 2000, 231, 105–111, doi: 10.1097/00000658-200001000-00015.
  22. Lakind J.S., Holgate S.T., Ownby D.R., Mansur A.H., Helms P.J., Pyatt D., Hays S.M.: A critical review of the use of Clara cell secretory protein (CC16) as a biomarker of acute or chronic pulmonary effects. Biomarkers 2007, 12, 445–467, doi: 10.1080/13547500701359327.
  23. Li G., Zhang Y., Fan Z.: Cellular signal transduction pathways involved in acute lung injury induced by intestinal ischemia-reperfusion. Oxid Med Cell Longev 2021, 2021, 9985701, doi: 10.1155/2021/9985701.
  24. Maretta M., Tóth Š., Jonecová Z., Veselá J.: Impact of alanyl-glutamine dipeptide on proliferative and inflammatory changes in jejunal mucosa after acute mesenteric ischemia. J Ped Surg 2014, 49, 1385–1389, doi: 10.1016/j.jpedsurg.2014.01.056.
  25. Matsuyama M., Yoshimura R., Hase T., Kawahito Y., Sano H., Nakatani T.: Study of cyclooxygenase-2 in renal ischemia-reperfusion injury. Transplant Proc 2005, 37, 370–372, doi: 10.1016/j.transproceed.2004.12.246.
  26. Mo L.-Q., Chen Y., Song L., Wu G.-M., Tang N., Zhang Y.-Y., Wang X.-B., Liu K.-X., Zhou J.: Osthole prevents intestinal ischemia-reperfusion–induced lung injury in a rodent model. J Surg Res 2014, 189, 285–294, doi: 10.1016/j.jss.2014.03.026.
  27. Mura M., Andrade C.F., Han B., Seth R., Zhang Y., Bai X.H., Waddell T.K., Hwang D., Keshavjee S., Liu M.: Intestinal ischemia-reperfusion–induced acute lung injury and oncotic cell death in multiple organs. Shock 2007, 28, 227–238, doi: 10.1097/SHK.0b013e318033e927.
  28. Sutariya B., Saraf M.: Betanin, isolated from fruits of Opuntia elatior Mill attenuates renal fibrosis in diabetic rats through regulating oxidative stress and TGF-ß pathway. J Ethnopharmacol 2017, 198, 432–443, doi: 10.1016/j.jep.2016.12.048.
  29. Tóth Š., Jonecová Z., Čurgali K., Maretta M., Šoltés J., Švaňa M., Kalpakidis T., Caprnda M., Adamek M., Rodrigo L., Kruzliak P.: Quercetin attenuates the ischemia reperfusion induced COX-2 and MPO expression in the small intestine mucosa. Biomed Pharmacol 2017, 95, 346–354, doi: 10.1016/j.biopha.2017.08.038.
  30. Tóth Š., Jonecová Z., Maretta M., Čurgali K., Kalpakidis T., Pribula M., Kusnier M., Fagová Z., Fedotova J., La Rocca G., Rodrigo L., Caprnda M., Zulli A., Ciccocioppo R., Mechirova E., Kruzliak P.: The effect of Betanin parenteral pretreatment on jejunal and pulmonary tissue histological architecture and inflammatory response after Jejunal ischemia-reperfusion injury. Exp Mol Pathol 2019, 110, 104292, doi: 10.1016/j.yexmp.2019.104292.
  31. Wang Z., Ji Y., Wang S., Wang R., Li Z., Kang A., Xu H., Shi M., Zhao M.: Protective effect of intestinal ischemic preconditioning on ischemia reperfusion-caused lung injury in rats. Inflammation 2015, 38, 424–432, doi: 10.1007/s10753-014-0047-3.
  32. Yang B., Cao F., Zhao H., Zhang J., Jiang B., Wu Q.: Betanin ameliorates isoproterenol-induced acute myocardial infarction through iNOS, inflammation, oxidative stress-myeloperoxidase/low-density lipoprotein in rat. Int J Clin Exp Pathol 2016, 9, 2777–2786.
  33. Yucel A.F., Kanter M., Pergel A., Erboga M., Guzel A.: The role of curcumin on intestinal oxidative stress, cell proliferation and apoptosis after ischemia/reperfusion injury in rats. J Mol Histol 2011, 42, 579–587, doi: 10.1007/s10735-011-9364-0.
  34. Zhang F., Tong L., Qiao H., Dong X., Qiao G., Jiang H., Sun X.: Taurine attenuates multiple organ injury induced by intestinal ischemia reperfusion in rats. J Surg Res 2009, 149, 101–109, doi: 10.1016/j.jss.2007.12.781.
  35. Zidar N., Odar K., Glavac D., Jerse M., Zupanc T., Stajer D.: Cyclooxygenase in normal human tissues—is COX-1 really a constitutive isoform, and COX-2 an inducible isoform? J Cell Mol Med 2009, 13, 3753–3763, doi: 10.1111/j.1582-4934.2008.00430.x.
Language: English
Submitted on: Apr 14, 2025
Accepted on: Nov 3, 2025
Published on: Nov 18, 2025
Published by: National Veterinary Research Institute in Pulawy
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2025 Milan Maretta, Štefan Tóth, Zuzana Fagová, Martin Urda, published by National Veterinary Research Institute in Pulawy
This work is licensed under the Creative Commons Attribution 4.0 License.

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