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An initial characterisation of the Unfolded Protein Response pathway in haematopoietic canine cancer cell lines – a necessary step for the future development of new therapies in dogs with neoplasia Cover

An initial characterisation of the Unfolded Protein Response pathway in haematopoietic canine cancer cell lines – a necessary step for the future development of new therapies in dogs with neoplasia

Open Access
|Sep 2023

References

  1. Altschul S.: Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res 1997, 25, 3389–3402, doi: 10.1093/nar/25.17.3389.
  2. American Veterinary Medical Association: Cancer in Pets. https://www.avma.org/resources/pet-owners/petcare/cancer-pets.
  3. Araujo N., Hebbar N., Rangnekar V.M.: GRP78 Is a Targetable Receptor on Cancer and Stromal Cells. EBioMedicine 2018, 33, 2–3, doi: 10.1016/j.ebiom.2018.06.030.
  4. Bu Y., Diehl J.A.: PERK Integrates Oncogenic Signaling and Cell Survival During Cancer Development. J Cell Physiol 2016, 231, 2088–2096, doi: 10.1002/jcp.25336.
  5. Casali C., Malvicini R., Erjavec L., Parra L., Artuch A., Fernández Tome M.C.: X-box binding protein 1 (XBP1): A key protein for renal osmotic adaptation. Its role in lipogenic program regulation. Biochim Biophys Acta Mol Cell Biol Lipids 2020, 1865, 158616, doi: 10.1016/j.bbalip.2020.158616.
  6. Elliot K., MacDonald-Dickinson V., Linn K., Simko E., Misra V.: Increase in gene-transcript levels as indicators of up-regulation of the unfolded protein response in spontaneous canine tumors. Can J Vet Res 2014, 78, 161–167.
  7. Feng L., Li M., Li Y., Zhu L., Chen M., Wei Q., Xu W., Zhou Q., Wang W., Chen D., Wang X., Jin H.: CK1δ stimulates ubiquitination-dependent proteasomal degradation of ATF4 to promote chemoresistance in gastric Cancer. Clin Transl Med 2021, 11, e587, doi: 10.1002/ctm2.587.
  8. Ge J., Sun H., Li J., Shan Y., Zhao Y., Liao F., Yang Y., Cui X., Liu Z.: Involvement of CHOP in activin Ainduced myeloma NS1 cell apoptosis. Oncol Rep 2019, 42, 2644–2654, doi: 10.3892/or.2019.7382.
  9. Gene Ontology Consortium: The Gene Ontology knowledgebase in 2023. Genetics 2023, 224, iyad031, doi: 10.1093/genetics/iyad031.
  10. George I., Sabbah H.N., Xu K., Wang N., Wang J.: β-Adrenergic receptor blockade reduces endoplasmic reticulum stress and normalizes calcium handling in a coronary embolization model of heart failure in canines. Cardiovasc Res 2011, 91, 447–455, doi: 10.1093/cvr/cvr106.
  11. Graner A.N., Hellwinkel J.E., Lencioni A.M., Madsen H.J., Harland T.A., Marchando P., Nguyen G.J., Wang M., Russell L. M., Bemis L.T., Anchordoguy T.J., Graner M.W.: HSP90 inhibitors in the context of heat shock and the unfolded protein response: effects on a primary canine pulmonary adenocarcinoma cell line. Int J Hyperth 2017, 33, 303–317, doi: 10.1080/02656736.2016.1256503.
  12. Grudzień M., Pawlak A., Kutkowska J., Zioło E., Wysokińska E., Hildebrand W., Obmińska-Mrukowicz B., Strzadala L., Rapak A.: A newly established canine NK-type cell line and its cytotoxic properties. Vet Comp Oncol 2021, 19, 567–577, doi: 10.1111/vco.12695.
  13. Guo B., Xiong X., Hasani S., Wen Y.-A., Li A.T., Martinez R., Skaggs A.T., Gao T.: Downregulation of PHLPP induced by endoplasmic reticulum stress promotes eIF2α phosphorylation and chemoresistance in colon cancer. Cell Death Dis 2021, 12, 960, doi: 10.1038/s41419-021-04251-0.
  14. He W., Qin D., Li B., Zhang H., Cheng X., Sun J., Hua J., Peng S.: Immortalized canine adipose-derived mesenchymal stem cells alleviate gentamicin-induced acute kidney injury by inhibiting endoplasmic reticulum stress in mice and dogs. Res Vet Sci 2021, 136, 39–50, doi: 10.1016/j.rvsc.2021.02.001.
  15. Jeon S.-J., Ahn J.-H., Halder D., Cho H.-S., Lim J.-H., Jun S.Y., Lee J.-J., Yoon Y., Choi M.-H., Jung C.-R., Kim J.-M., Kim N.-S.: TIPRL potentiates survival of lung cancer by inducing autophagy through the eIF2α-ATF4 pathway. Cell Death Dis 2019, 10, 959, doi: 10.1038/s41419-019-2190-0.
  16. Kim T.W., Hong D.-W., Hong S.H.: PB01 suppresses radio-resistance by regulating ATR signaling in human non-small-cell lung cancer cells. Sci Rep 2021, 11, 12093, doi: 10.1038/s41598-021-91716-z.
  17. Litwak S.A., Wali J.A., Pappas E.G., Saadi H., Stanley W.J., Varanasi L.C., Kay T.W.H., Thomas H.E., Gurzov E.N.: Lipotoxic Stress Induces Pancreatic β -Cell Apoptosis through Modulation of Bcl-2 Proteins by the Ubiquitin-Proteasome System. J Diabetes Res 2015, 2015, 280615, doi: 10.1155/2015/280615.
  18. Mootha V.K., Lindgren C.M., Eriksson K.-F., Subramanian A., Sihag S., Lehar J., Puigserver P., Carlsson E., Ridderstråle M., Laurila E., Houstis N., Daly M.J., Patterson N., Mesirov J.P., Golub T.R., Tamayo P., Spiegelman B., Lander E.S., Hirschhorn J.N., Altshuler D., Groop L.C.: PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet 2003, 34, 267–273, doi: 10.1038/ng1180.
  19. Mortazavi A., Williams B.A., McCue K., Schaeffer L., Wold B.: Mapping and quantifying mammalian transcriptomes by RNA-Seq. Nat Methods 2008, 5, 621–628, https://doi.org/10.1038/nmeth.1226.
  20. Muñoz-Guardiola P., Casas J., Megias-Roda E., Solé S., Perez-Montoyo H., Yeste-Velasco M., Erazo T., Diéguez-Martínez N., Espinosa-Gil S., Muñoz-Pinedo C., Yoldi G., Abad J.L., Segura M. F., Moran T., Romeo M., Bosch-Barrera J., Oaknin A., Alfón J., Domenech C., Fabriàs G., Velasco G., Lizcano J.M.: The anti-cancer drug ABTL0812 induces ER stress-mediated cytotoxic autophagy by increasing dihydroceramide levels in cancer cells. Autophagy 2021, 17, 1349–1366, doi: 10.1080/15548627.2020.1761651.
  21. Nadeau M.È., Rico C., Vivancos M., Filimon S., Paquet M., Boerboom D.: Pharmacological targeting of valosin containing protein (VCP) induces DNA damage and selectively kills canine lymphoma cells. BMC Cancer 2015, 15, 1–14, doi: 10.1186/s12885-015-1489-1.
  22. Nakaichi M., Taura Y., Kanki M., Mamba K., Momoi Y., Tsujimoto H., Nakama S.: Establishment and Characterization of a New Canine B-Cell Leukemia Cell Line. J Vet Med Sci 1996, 58, 469–471, doi: 10.1292/jvms.58.469.
  23. Nguyen H., Uhal B.D.: The unfolded protein response controls ER stress-induced apoptosis of lung epithelial cells through angiotensin generation. Am J Physiol Lung Cell Mol Physiol 2016, 311, L846–L854, doi: 10.1152/ajplung.00449.2015.
  24. Papadopoulos J.S., Agarwala R.: COBALT: constraint-based alignment tool for multiple protein sequences. Bioinformatics 2007, 23, 1073–1079, doi: 10.1093/bioinformatics/btm076.
  25. Pawlak A., Rapak A., Zbyryt I., Obmińska-Mrukowicz B.: The effect of common antineoplastic agents on induction of apoptosis in canine lymphoma and leukemia cell lines. In Vivo 2014, 28, 843–850.
  26. Pillai-Kastoori L., Heaton S., Shiflett S.D., Roberts A.C., Solache A., Schutz-Geschwender A.R.: Antibody validation for Western blot: By the user, for the user. J Biol Chem 2020, 295, 926–939, doi: 10.1074/jbc.RA119.010472.
  27. Puthalakath H., O’Reilly L.A., Gunn P., Lee L., Kelly P.N., Huntington N.D., Hughes P.D., Michalak E.M., McKimm-Breschkin J., Motoyama N., Gotoh T., Akira S., Bouillet P., Strasser A: ER Stress Triggers Apoptosis by Activating BH3-Only Protein Bim. Cell 2007, 129, 1337–1349, doi: 10.1016/j.cell.2007.04.027.
  28. Rozpędek W., Pytel D., Mucha B., Leszczynska H., Diehl J.A., Majsterek I.: The Role of the PERK/eIF2α/ATF4/CHOP Signaling Pathway in Tumor Progression During Endoplasmic Reticulum Stress. Curr Mol Med 2016, 16, 533–544, doi: 10.2174/1566524016666160523143937.
  29. Rütgen B.C., Hammer S.E., Gerner W., Christian M., Guija de Arespacochaga A., Willmann M., Kleiter M., Schwendenwein I., Saalmüller A.: Establishment and characterization of a novel canine B-cell line derived from a spontaneously occurring diffuse large cell lymphoma. Leuk Res 2010, 34, 932–938, doi: 10.1016/j.leukres.2010.01.021.
  30. Siwecka N., Rozpędek W., Pytel D., Wawrzynkiewicz A., Dziki A., Dziki Ł., Diehl J.A., Majsterek I: Dual role of Endoplasmic Reticulum Stress-Mediated Unfolded Protein Response Signaling Pathway in Carcinogenesis. Int J Mol Sci 2019, 20, 4354, doi: 10.3390/ijms20184354.
  31. Subramanian A., Tamawo P., Mootha V.K., Mukherjee S., Ebert B.L., Gillette M.A., Paulovich A., Pomeroy S.L., Golub T.R., Lander E.S., Mesirov J.P.: Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci 2005, 102, 15545–15550, doi: 10.1073/pnas.0506580102.
  32. Tang Z.-H., Chen X., Wang Z.-Y., Chai K., Wang Y.-F., Xu X.-H., Wang X.-W., Lu J.-H., Wang Y.-T., Chen X.-P., Lu J.-J.: Induction of C/EBP homologous protein-mediated apoptosis and autophagy by licochalcone A in non-small cell lung cancer cells. Sci Rep 2016, 6, 26241, doi: 10.1038/srep26241.
  33. Teng Y., Gao M.. Wang J., Kong Q., Hua H., Luo T., Jiang Y.: Inhibition of eIF2α dephosphorylation enhances TRAIL-induced apoptosis in hepatoma cells. Cell Death Dis 2014, 5, e1060–e1060, doi: 10.1038/cddis.2014.24.
  34. Wang H.-Q., Du Z.-X., Zhang H.-Y., Gao D.-X.: Different Induction of GRP78 and CHOP as a Predictor of Sensitivity to Proteasome Inhibitors in Thyroid Cancer Cells. Endocrinology 2007, 148, 3258–3270, doi: 10.1210/en.2006-1564.
  35. Wang L.-L., Hu R.-C., Dai A.-G., Tan S.-X., Xu M., Kong C.-C., Chen Y.-R., Fu D.-Y.: CHOP overexpression sensitizes human non-small cell lung cancer cells to cisplatin treatment by Bcl-2/JNK pathway. Am J Transl Res 2021, 13, 6279–6287.
  36. Wu L., Huang X., Kuang Y., Xing Z., Deng X., Luo Z.: Thapsigargin induces apoptosis in adrenocortical carcinoma by activating endoplasmic reticulum stress and the JNK signaling pathway: an in vitro and in vivo study. Drug Des Devel Ther 2019, 13, 2787–2798, doi: 10.2147/DDDT.S209947.
  37. Wu W., Yang Y., Deng G., Ma L., Wei G., Zheng G., Han X., He D., Zhao Y., He J., Cai Z., Yu R.: Vernodalol enhances TRAIL-induced apoptosis in diffuse large B-cell lymphoma cells. Mol Carcinog 2017, 56, 2190–2199, doi: 10.1002/mc.22672.
  38. Yokota S., Kobatake Y., Noda Y., Nakata K., Yamato O., Hara H., Sakai H., Nishida H., Maeda S., Kamishina H.: Activation of the unfolded protein response in canine degenerative myelopathy. Neurosci Lett 2018, 687, 216–222, doi: 10.1016/j.neulet.2018.09.040.
Language: English
Page range: 447 - 458
Submitted on: Mar 28, 2023
Accepted on: Aug 2, 2023
Published on: Sep 20, 2023
Published by: National Veterinary Research Institute in Pulawy
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2023 Beatriz Hernández-Suárez, David A. Gillespie, Bożena Obmińska-Mrukowicz, Aleksandra Pawlak, published by National Veterinary Research Institute in Pulawy
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.